Excitotoxicidad Flashcards

1
Q

Principal causa de la excitotoxicidad

A

Acciones tóxicas de aa excitatorios

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2
Q

Son aminoácidos excitatorios

A

Glutamato y aspartato

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3
Q

Subtipos de receptores NMDA más permeables

A

NR1 y NR2B

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4
Q

Aumento de calcio produce

A

Despolarizacion de membrana, act vías caspasas y produce radicales libres

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5
Q

Principal vía de producción de ROS en la excitotoxicidad

A

NO + OO-àONOO- (peroxinitrito)

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6
Q

CIERTO/FALSO: los astrocitos tienen receptores AMPA y NMDA

A

FALSO; tienen AMPA, pero no NMDA

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7
Q

¿Cómo participan los astrocitos a la excitotoxicidad?

A

menor recaptura de glutamato o liberación activa de glutamato

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8
Q

Células víctimas totales del daño excitotóxico

A

Oligodendrocitos

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9
Q

Receptores presentes en procesos de muerte retardada

A

AMPA

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10
Q

¿Qué provoca la falla en bombas electrogénicas?

A

Muerte celular: necrosis-oncosis

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