Excitable cell Flashcards
Forces that control ion movement
diffusion and electrical field
How much current depends on
electrical potential (V) Electrical conductance - how easy it is for charge to more from on point to another
there is no flow if either of these = 0
conductance measured in ?
siemens
nernst equation vs goldmans
N = just 1 ion taken into account. calculates equilibrium potential G = looks at relative permeabilities of more than 1 ion
Action of calcium
pumps transpot calcium out of neuroness maintaining low intracellular. changes detected by many proteins used as a signalling ion
high intracellular concentration is toxic
Eion?
equilibrium potential
if membrane where selectively permeable to that ion calculated using nernst equation
Graded vs action potential
graded - variable size, pass both ways along neurone membrane. vary according to strength to stimulus
action - all or nothing, fixed size, propagate in 1 direction
resting potential ?
set up by pumps that maintain distribution of charge molecules. sodium potassium atpase transport 2k into cell and 3na out
set up negative membrane potential
Sodium channels
open in response to a depolarisation
need to repolarise so can remove the innactivation ball so can go again= refractory period
K channels lead to repolarisation
Na channels behind are closed s lead to unidirectional
Factors affecting velocity ?
diameter - greater diameter the greater V
Myelin - insulate to stop leaking by saltatory conduction
EPSP +IPSP
excitatory post synaptic potential and inhibitor.
eps can be shunted by the activation of a nipsp
temporal vs spatial summation
spatial - multiple presynaptic
temporal - 1 over time