Exchange Of Substances Flashcards
What is peristalsis (oesophagus, intestines etc)
Squeezing motion (autonomic nervous system)
Stomach
Muscular sac
Stores and digests food
Inner layer produces enzymes like pepsin
Ileum
Long muscular tube at the end of small intestine where most digestion occurs
Produces enzymes from epithelial cells that line walls and glands pour their secretions into it
Large intestine
(Around the outside)
Absorbs water
Rectum
Stores faeces to be ejected from the anus
Salivary glands
Secretes saliva which contains salivary amylase that hydrolyses some starch into maltose but mainly breaks down into small pieces
Pancreas
Under stomach
Secretes pancreatic juice
Contains pancreatic amylase, protease,carbohydrate,lipase and nucleases
Bile from liver is stored in
The gallbladder
Digestion is
The physical and chemical breakdown of food
Physical break down
No bonds are broken
Large pieces are broken down by teeth (mastication) and churned by stomach muscles
Purpose of physical breakdown
Makes injection possible
Larger surface area for efficient chemical digestion
Chemical digestion
Hydrolyses large, insoluble molecules into small, soluble ones
Uses a H20 molecules
Carbohydrate digestion process
In mouth, physical digestion by mastication and chemical digestion by salivary amylase, which hydrolyses some starch into maltose but mainly, into smaller chunks for ingestion. Mineral salts in saliva maintain a neutral pH.
Peristalsis pushes food through oesophagus into stomach, where (pH around 2) a highly acidic environment denatures amylase enzyme and no hydrolysis of starch occurs. The churning of the walls breaks food, including undigested starch into smaller pieces (physical digestion)
Then food moves through peristalsis into the duodenum, where pancreatic juice and bile are secreted through the same duct. Pancreatic amylase hydrolyses the remaining starch, into the disaccharide maltose.
Alkaline salts keep the pH neutral (from intestinal wall).
Peristalsis pushes food from duodenum into ileum, where epithelial cells that line the walls, produce the membrane- bound disaacharidase maltase.(not released into the lumen)
This hydrolyses maltose into alpha glucose, which can then be absorbed via co-transport.
Sucrose (found mainly in fruits) is hydrolyses by —— into —— and ——
Sucrase
Glucose
Fructose
Lactose (found mainly in dairy) is hydrolysed by —— into —— and ——
Lactase
Glucose
Galactose
What is chyme
Name of Food moving from stomach to ileum
Alkaline salts in ileum purpose
Keep pH neutral
Lipid digestion procedure
In small intestine
Lipases (produced by pancreas) hydrolyse the ester bond in triglycerides to produce a monoglyceride and two fatty acids
These then undergoes emulsification, where they are split into micelles (tiny droplets) by bile salts and increases the surface area of lipids to speed up enzyme action
Emulsification is —— process
Physical
A Michelle structure describe
Lipid has bile salts attached to it which are hydrophobic on inside (touching lipid) and hydrophilic on the outside
Protein digestion
Endopeptidases hydrolyse peptide bonds between amino acids in the central region of the protein molecule to form series of peptide molecules
Exopeptidases hydrolyse the peptide bonds on the terminal amino acid, from the peptide molecules formed after Endopeptidases work, releasing dipeptide and amino acids.
Dipeptidases hydrolyse the peptide bonds between dipeptide
They are membrane bound to epithelial cells of the ileum.
Why is it more efficient to digest proteins using Endopeptidases rather than exopeptidases?
Because Endopeptidases work on the central region, they split up the protein into smaller chunks, which have a larger surface area for exopeptidases to work upon, (more terminal regions to work upon), hence increases efficiency and rate of digestion.
Adaptations of the ileum for absorption
Villi/microvilli - large SA
Thin walls so small diffusion distance and capillaries
Muscle moves, which mixes contents so, maintains a diffusion gradient
Blood circulates maintaining diffusion gradient
Absorption of triglycerides process
Micelles (4-7nm) come into contact with the epithelial cell lining of ileum, due to movement within lumen, where they break down, releasing monoglyceride and fatty acids - which are non-polar so diffuse across cell-surface membrane easily.
Once in cell they are transported to smooth ER, where they recombine to form triglycerides.
Then to golgi where the triglycerides associate with cholesterol and lipoproteins to form structures called chylomicrons - which are special particles adapted for the transport of lipids.
They move out the epithelial cell via exocytosis and enter lymphatic capillaries called lacteals at the centre of each villus.
Once in blood system, they are hydrolysed by an enzyme in the endothelial cells of the blood capillaries, from where they diffuse into cells.
Three organelles expected to be in abundance in epithelial cell that lines ileum
ER-recombination of triglycerides
Golgi- associate with cholesterol and lipoproteins to form chylomicrons
Vesicles - to exit cell via exocytosis
What is the purpose of chylomicrons travelling through the lymphatic system?
Means they bypass the liver, hence it isn’t overloaded.
What do chylomicrons look like and what are they made of and have —— heads and are suspended in ——, which is possible because they are ——
Iridescent droplets
Triglycerides associated with cholesterol and lipoproteins
Hydrophobic heads, hence are stable, and can be suspended in plasma.
Trachea
Flexible airway made of muscle, ciliated epithelial cells and goblet cells that are supported by rings of cartilage that prevent collapse due to air pressure, during inhalation - produces mucus as well.
Bronchioles
Series of branching sub division of bronchus; epithelial cell lining and a smooth muscle lining that allows constriction of flow of air.
Bronchi
Two division of trachea, each leading to one lung. Similar structure to trachea and produces mucus and has cillia. Larger bronchi are supported by a proportional amount of cartilage.
Ribcage
Bony box that supports and protects lungs - moved by muscles between them
Lungs
Loved structured series of highly branched tubules
Diaphragm
Sheet of muscle involved in ventilation
Separates the thorax from the abdomen
Alveoli
Minute air sacs, where gas exchange occurs
Elastic fibres between them allow stretching when inflated and recoil during expiration.
During inspiration
External intercostal muscles contract and elevates ribs
Internal intercostal muscles relaxes
Diaphragm contracts and flattens
Thorax volume increases
Pressure in thorax decreases
Direction of air movement is into the lungs
During expiration
External intercostal muscles relaxes and lowers ribs
Internal intercostal muscles contracts
Diaphragm relaxes and domes
Thorax volume decreases
Pressure in thorax increases
Direction of air movement is out of lungs