Excess Androgens, Congenital Disorders and Male Hypogonadism Flashcards
What is hirsutism?
Excess hair in a male pattern, in a woman
What causes hirsutism?
Excess androgens at the hair follicle
Give 4 causes of hirsutism which present with a long history, fairly normal testosterone and no virilisation?
PCOS, familial, idiopathic, non-classical CAH
How does hirsutism as a result of an adrenal or ovarian tumour present?
Short history with virilisation
What is non-classical CAH?
A partial 21 alpha hydroxylase deficiency which presents in adolescence
How may non-classical CAH present?
Hirsutism, menstrual irregularity, infertility
What treatment is used in non classical CAH?
Low dose corticosteroid
What are the testosterone levels in an androgen secreting tumour?
High (>5)
Which out of adrenal and ovarian androgen secreting tumours are more likely to be malignant?
Adrenal
XO is what condition? Which sex does this affect?
Turner’s syndrome, only affects girls
What are some features of Turner’s syndrome?
Short stature, webbed neck, wide spaced nipples, lymphedema, delayed puberty
What should be screened for in an individual with Turner’s syndrome?
Cardiac and renal problems, IBD, osteoporosis and scoliosis
What cardiac problems may Turner’s cause?
Coarctation of the aorta, bicuspid aortic valve, hypo plastic left heart
What is XX gonadal dysgenesis?
Absent ovaries but no chromosomal abnormalities
What is testicular feminisation?
Androgen insensitivity syndrome: genetically XY but phenotypically female