Examples to remember Flashcards
Give 3 examples of drugs that have their pharmacokinetics affected by genetic variation
Codeine - CYP2D6
Tramadol - CYP2D6
Azathioprine - TPMT
Clopidogrel - CYP2C19
Give 2 examples of diseases where genotyping could lead to administration of a more effective treatment
MODY
Neonatal diabetes
Give 2 examples of drugs that have their pharmacodynamics affected by genetic variation
Beta-blockers - ADBR1
Volatile anaesthetics - RYR1
Give 3 examples of drugs that has both its pharmacokinetics and pharmacodynamics affected by genetic variation
Simvastatin - SLCO1B1, HMGCR
Warfarin - CYP2C9, VKORC1
5-FU - DPHD, TYMS
Give 2 examples of drugs which can cause idiosyncratic hypersensitivity reactions
Abacavir - HLA-B
Carbamazepine - HLA-A and HLA-B