Examples to remember Flashcards

1
Q

Give 3 examples of drugs that have their pharmacokinetics affected by genetic variation

A

Codeine - CYP2D6
Tramadol - CYP2D6
Azathioprine - TPMT

Clopidogrel - CYP2C19

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2
Q

Give 2 examples of diseases where genotyping could lead to administration of a more effective treatment

A

MODY

Neonatal diabetes

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3
Q

Give 2 examples of drugs that have their pharmacodynamics affected by genetic variation

A

Beta-blockers - ADBR1

Volatile anaesthetics - RYR1

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4
Q

Give 3 examples of drugs that has both its pharmacokinetics and pharmacodynamics affected by genetic variation

A

Simvastatin - SLCO1B1, HMGCR

Warfarin - CYP2C9, VKORC1
5-FU - DPHD, TYMS

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5
Q

Give 2 examples of drugs which can cause idiosyncratic hypersensitivity reactions

A

Abacavir - HLA-B

Carbamazepine - HLA-A and HLA-B

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