Examples Flashcards
How can you measure the impacts of Nature and Nurture?
Parent offspring regression
Twin studies
Animal models
Clones
Problems with Narrow Sense heritability
Depends on environment variation
Female choice and lek paradox
Constant selection on a gene should reduce genetic variation
Human genome project problems?
Biggest finding was that there wasn’t a 1:1 relationship between genes and phenotype
How did caucasian and Aboriginal children differ in spatial memory?
Aboriginal children better, saw shapes rather than objects
Other examples of spatial memory differences?
London Cab Driver’s hippocampus
African athleitism: selection pressures from life style - stealing cattle in one town
What is the flow of actions in the central DOGMA?
Replication -> Transcription -> Translation
How does a mutation occur?
DNA polymerase is very accurate but sometimes mispairing/slippage
Normally 99% corrected but if not = MUTATION
Consequences of mutation in mitosis
Very little effect as other cells dont have similar mutations
2 major sources of Variation
Mutations
Recombination/Crossing over
Mechanisms of epigenetic inheritance
- Make DNA unable to bind to RNA transferase( Horizontal memory, Vertical memory)
- Chromatin/Histone remodelling
- Alternative Splicing
- Micro-RNA (mRNA)
Why is early environment linked to adulthood disease?
Long term effects of early development
4 hypothesis of why early development affects metabolic function
- 1992 Thrifty phenotype
- Thrifty phenotype as adaptive maternal effect
- PAR
- Matching between maternal and offspring phenotype
Examples of PAR
Meadow voles and coats
WWII correlational studies
Predictions of early vs. late life conditions (4)
- Environmental Matching
- Silver Spoon
- Matching/Silver Spoon
- Silver spoon/mactching II
Correlational evidence of early/late life conditions
Supportive of Silver spoon (2)