Exam Three: Renal, Digestive, Reproductive Flashcards
What cells produce androgen-binding protein?
Sertoli Cells
What cells produce testosterone in the testis?
Leydig Cells
What cells found in the seminiferous tubules do not produce sperm?
Sertoli Cells
The gubernaculum is important in what process?
The descent of the testes
What type of cells release pepsinogen?
Chief cells
Functions of the stomach do not include _________ absorption
Protein
Functions of the stomach include _______ digestion, ______ denaturing, _______ of food, and storage of _______ _____.
protein, protein, sterilization, ingested food
What macromolecule is not digested in the mouth?
Fats
What type of cells are a source of intrinsic factor?
Parietal Cells
What type of cells release gastrin?
Enteroendocrine cells
What percentage of filtrate volume will be reabsorbed by the renal tubule?
99%
How are materials returned to the peritubular capillaries?
Diffusion and Osmosis
What three factors make the movement of materials to the peritubular capillaries easy?
1) decreased blood pressure due to narrow efferent arteriole
2) slow flow rate
3) increased colloid osmotic pressure
Where is 65-70% of filtrate reabsorbed?
Proximal Convoluted Tubule
Great length, prominent microvilli, and abundant mitochondria are all characteristics of the _______
Proximal Convoluted Tubule
Why are there so many mitochondria in the PCT?
They produce the ATP needed for active transport
The transcellular route is through _______ cells.
Epithelial
The paracellular route is between _______ cells.
Epithelial
Epithelial nephrocytes have special permeability to _______
Sodium
Cells of the PCT have a special ______ transport protein that binds to ______ and does not act unless also bound to sodium.
glucose, glucose
Why do glucose transport proteins also need to bind to sodium?
They harness the concentration gradient and act as a Sodium Dependent Cotransporter
The transporter for glucose is only present in the ____
PCT
Because there are a fixed number of transporter proteins that may become saturated, there is a _______ _________
transport maximum
The transport maximum of glucose is ____mg/minute
320
Diabetes mellitus causes glycosuria because the glucose level exceeds the _______ _________
transport maximum
Glucose transport is a form of _______ ______ transport
secondary active
Besides glucose, another sodium-dependent cotransporter material is _____ ______
amino acids
Amino acid transport proteins, like glucose transport proteins, have a ________ ________
transport maximum
Water reabsorption is _______
passive
There is more water in the ______ than outside of the ______
filtrate, PCT
Cells of the PCT are extremely permeable to water because they have ________
aquaporins
Filtrate becomes ____ concentrated in water
less
Water concentration will increase in the filtrate until it exceeds the pressure of water outside of the ___ and causes _______, leaving the filtrate _____ concentrated
PCT, osmosis, more
By water leaving the PCT, it creates a _______ ___________
concentration gradient
____ follows water out of the PCT by a solvent drag and diffusion because of the concentration gradient shift
K+ (potassium)
Na+ will always take an anion like ___ to maintain the electric balance.
Cl- (chlorine)
Because nephrocytes are permeable to water, they are also permeable to ______, which takes advantage of the aquaporins
urea
Because of the solvent drag, there is a percentage of ____ and other __________ ______ that will be reabsorbed.
urea, nitrogenous wastes
_____ _____ when present in the blood can have antiparasitic properties
Uric Acid
The primary function of tubular reabsorption in the loop of henle is to _______________
enable the collecting duct to concentrate urine and conserve water
Only ___% of the original filtrate remains when it enters the loop of henle
30
the osmolarity of filtrate entering the loop of henle is ____
300 miliosmoles
Extracellular fluid becomes more ______ as it descends from the cortex to the medulla
salty
osmolarity in the medulla can increase up to ______mOsm/L
1,200
The _________ limb of the loop of henle is very permeable to water
descending
water leaves as the limb descends via ________
osmosis
The descending limb of the loop of henle allows water to leave but does not allow ______ to follow, concentrating the tubular fluid
NaCl
The ascending limb of the loop of henle is/is not permeable to water
is not
the ascending limb of the loop of henle contains a lot of ________ cotransporter proteins
Na-K-Cl2
Why are there 2 Cls in the Na-K-Cl2 cotransporter protein?
for neutrality
The Na-K-Cl2 cotransporter protein is what _____ inhibits and what maintains the high osmolarity of the medulla
Lasix
Tubular fluid becomes _____ as it ascends into the cortex
hypotonic
The Na-K-Cl2 that is released from the ascending limb of the loop of henle is taken up by the _____ ______ in its ________ parallel
vasa recta, ascending
Water is reabsorbed by the vasa recta’s ______ parallel
descending
The parallels and reabsorption of the vasa recta are known as
countercurrent exchange
____% of filtrate is reabsorbed in the loop of henle, leaving ___%
25-30, 10
what percentage of the original volume enters the DCT?
10%
electrolyte and waste concentration of filtrate is no longer similar to blood plasma once it enters the ____
DCT
The DCT is very sensitive to which hormone?
Aldosterone
In the DCT there is Na+ ___________ , H20 ___________ and K+ __________
reabsorption, reabsorption, secretion
Aldosterone triggers the production of ___ channels into the basal membrane
Na+
Calcium channels in the DCT are called _______
C-H-ATPase
Reabsorption of Ca is regulated by ___ and _______
PTH, calcitriol
Less than __% of the original filtrate volume is left when it enters the collecting system
5
The collecting system is sensitive to aldosterone, causing H20 _________, Na+ __________, K _________ and urea _________
reabsorption, reabsorption, secretion, reabsorption
Aquaporins are only present when ____ is present
ADH
The movement of substances from the peritubular capillaries into the tubule is called _______ _________
tubular secretion
____ is both water and lipid soluble
C02
Urochrome comes from the breakdown of ___________
hemoglobin
Normal urine pH is ____
6.0
Urine is composed of ___% H20
95
normal urine output is ____L/day
1-2
diabetes can be defined as chronic ______ with hyperglycemia
polyuria
Diabetes __________ is caused by hyposecretion of ADH
insipidus
diuretics function to ________ urine output and _______ blood volume
increase, decrease
diuretic mechanism of action is to __________ glomerular flow rate and ________ tubular reabsorption
increase, decrease
Nephrotic syndrome can be defined as __________ from glomerular injury
proteinuria
Nephroptosis can be defined as _______ ________
floating kidney
increased fluid pressure can obstruct the ureter resulting in a condition called ___________
hydronephrosis
chronic renal failure can be defined as irreversible loss of ________
nephrons
acute renal failure can be defined as an abrupt ________ in ________
decline, function
acute glomerulonephritis can be defined as _________ ___________ of the glomeruli
autoimmune inflammation
What hormone targets the Nephrone loop, DCT and CD causing Na+ reabsorption, K+ secretion and indirectly promoting Cl- and H20 reabsorption?
aldosterone
What hormone targets the PCT and afferent and efferent arterioles reducing water loss, reducing GFR, encouraging water intake and constricting blood vessels, raising blood pressure?
Angiotensin II
What hormone acts on the collecting duct promoting H20 reabsorption, reducing urine volume and increasing concentration?
ADH
What hormone acts on the collecting duct and afferent and efferent arterioles increasing GFR, constricting the efferent arteriole, dilating the afferent arteriole, increasing urine volume and lowering blood pressure?
Atrial Natriuretic Peptide
What hormone acts on the DCT causing reduced Ca2+ secretion?
Calcitonin
What hormone acts on the DCT causing CA2+ reabsorption?
Calcitriol
What hormones act on the juxtaglomerular apparatus and afferent arteriole, inducing renin secretion, constricting the afferent arteriole, and reducing GFR and urine volume?
Epinephrine and Norepinephrine
What hormone acts on the PCT, DCT and nephron loop promote Ca2+ reabsorption and increase phosphate excretion?
Parathyroid Hormone
Accessory digestive organs include the _______, tongue, ________, salivary glands, _______ and pancreas
teeth, gallbladder, liver
Digestive processes of the mouth include ________ of materials, __________, _________ and limited _______ by saliva
analysis, mastication, lubrication, digestion
Salivary amylase breaks down _______________ and works at a _______ pH
polysaccharides, neutral
salivary lipase breaks down _________ and works at a ______ pH
triglycerides, low
lysozyme breaks down gram __ bacteria
positive +
IgA antibodies in saliva function to _______ ________
block infection
mucin functions to ________ _____
lubricate food
secretion of saliva is controlled by the __________ nervous system
autonomic
__________ _________ of the medulla oblongata send action potentials down cranial nerves to stimulate _______
salivatory nuclei, salivation
phases of salivary release include the __________ and ____ phases
cephalic, oral
the ___________ phase of salivary release is brought on by the sight, thought, and smell of food.
cephalic
the ______ phase of salivary release is brought on by chemoreceptors and pressure receptors
oral
sympathetic stimulation results in the production of a _______, _______ saliva with ________ enzyme content
smaller, viscous, little
what substances are absorbed in the mouth?
lipid-soluble substances
the stomach has some limited digestion of _______ and _______
proteins, lipids
the acidity of the stomach and digestive enzyme, pepsin, helps to _______ the food
sterilize
the stomach liquifies food to produce _______
chyme
the stomach is lined with _____ ______ ___________
simple columnar epithelium
the stomach lining produces a carpet of mucus to _________ _____ _________ _____ ______
protect the stomach from acid
the epithelium of the stomach is organized into shallow depressions called _______ _____
gastric pits
B12 helps with the production of _____ ________ ______
red blood cells
gastric pits are lined with columnar epithelium called ______ _________ which release mucus
mucus epithelium
at the base of the gastric pits, there are two or three _________ ________
gastric glands
gastric glands have five types of cells: _________ ______ ______, _________ ______, _____ _____, ____________ ______, and __________ ______
mucus neck cells, parietal cells
mucus neck cells produce _______
mucin
parietal cells produce ________ ______
intrinsic factors
intrinsic factor is required for the absorption of ____ by the intestine
B12
Fe2 binds to gastroferritin and is absorbed by the ____ _______
small intestine
The process of carbonic anhydrase producing H+HCO3, H-K-ATPase pumping out H in exchange for K, and Cl shifting into the cell as HCO3 goes to the blood is called the
alkaline tide
pepsin digests _______
proteins
chief cells in infants produce _______ and _________ _______
rennin, gastric lipase
gastrin and somatostatin are produced by ______________ cells
enteroendocrine
gastrin is produced by ___ cells and _________ secretion by parietal and chief cells
g, stimulates
somatostatin is produced by ___ cells which weakly inhibits ______ release
d, gastrin