Exam qs

Question 1

Which of the following are true?
a) are DII4 positive
b) contributes to lumenisation of the neovessel
c) have higher markers of proliferation than other endothelial cells
d) have reduced glycolysis compared to tip cells
e) respire anaerobically

Answer 1

b, c and d

Question 2

Fill in the blanks:
Lymphatic vessels are -[1]- open in response to -[2]- interstitial pressure. Proliferation and migration, in response to cytokines such as -[3]- result in -[4]-. Increased -[5]- and density of the lymphatic vasculature results in an increased -[6]- into the -[7]- circulation. This system permits interstitial fluid and -[8]- leukocytes to be returned into the circulation via -[9]-.

Answer 2

1) pulled
2) increased
3) VEGF-C
4) lymphangiogenesis
5) function
6) drainage
7) venous
8) educated
9) lymph nodes

Question 3

Which checkpoint inhibitor is currently being used clinically in the treatment of patients with cancer?

Answer 3

Anti-CTLA4 antibodies