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Pharm Exam IV (KAM) > Exam IV - Uterine > Flashcards

Exam IV - Uterine Flashcards

1
Q

Oxytocin

Indications

A
  1. Induce labor for vaginal delivery
  2. Promote lactation
  3. PTx and prevention of post partum hemorrhage
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2
Q

Oxytocin

Mechanism

A

↑SMC: Hormone released during labor by binding to receptor and altering transmembrane ion currents in myometrium.

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3
Q

Oxytocin

ADME

A

Cervical ripening must happen first A; nasal spray contract mamry glands

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4
Q

Oxytocin

Adverse

A

Uterine tachysystole (common) Maternal death (rare) Fetal damage/death if cervix is not dilated H2O toxicity/HoNa+

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5
Q

Misoprostal

Indications

A
  1. Induce labor
  2. Post partum hemorrhage prevention
  3. Induce contrxns post missed or incomp miscarriage in early preg
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6
Q

Misoprostal

Mechanism

A

Prostaglandins

↑SMC

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7
Q

Misoprostal

Adverse

A
  1. Bleeding

2. GI SM contrxn: NV&D

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8
Q

Misoprostal

Contraindications

A

Previous cesarean

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9
Q

Methylergotamine (Ergot alkaloids)

Indication

A
  1. Post partum hemorrhage prevention 2. Prolonged uterin contrxn post D&C
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10
Q

Methylergotamine

Mechanism

A

↑SMC: partial agonist/antagonist at α-adrenegergic, DA & 5-HT receptors 2. Vasoconstrictive: ↑uterine motor activity, hi doses →sustained contrxn

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11
Q

Methylergotamine

ADME

A

Combo w/ oxytocin

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12
Q

Methylergotamine

Adverse

A
  1. Elevated BP 2. N&V
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13
Q

Methylergotamine

Contraindications

A

Many… 1. HTN

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14
Q

Tocolytic Agents

Indication

A
  1. Anti-contraction: tocolysis 2. Used to delay preterm delivery for admin of CWS for fetal lung development
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15
Q

Tocolytic Agents

Mechanism

A

↓SMC

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16
Q

Tocolytic Agents

Drug List

A
  1. MgSO4 2. Terbutaline; β2 Agonist 3. Ca2+ channel blockers (Nifedipine 4. NSAIDS: Indomethacin 5. Oxytocin receptor antagonists (Atosiban 6. NO inducers
17
Q

Magnesium Sulfate

Indications

A

Seizure prevention & preeclampsia

18
Q

Magnesium Sulfate

Mechanism

A

Ca2+ Channel block: ↓ Freq/strength of contrxns

19
Q

Magnesium Sulfate

Adverse

A
  1. Hypermagnesemia: monotor blood 2. Pulmonary edema
20
Q

Terbutaline

Indications

A
  1. Relaxes uterine muscle 2. Prolongs delivery for CS admin (24-48H)
21
Q

Terbutaline

Mechanism

A

β2 agonist: inactivates myosin light chain kinase

22
Q

Terbutaline

Adverse

A
  1. Adverse effects to mom and baby limit use 2. Reflex tachycardia, hi doses lead to β1 effects 2. HoTN

Pharm Exam IV (KAM) (3 decks)

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