Exam IV Flashcards
What is MHC?
Major Histocompatibility Complex protein
Where is MHC located?
On the surface of plasma membrane of cells
Which type of T cells do MHC class I and MHC class II interacts with?
MHC Class I = Tc and CTL cells MHC class II = Th cells.
What happens when an MHC class I protein is bound to an antigen?
It interacts with a Tc or CTL cell
What happens when an MHC class I protein is not bound to an antigen?
It keeps NK cells from killing the cell.
What type of cells are MHC class II proteins found on?
APC cells including dendritic, macrophages and B cells.
On what type of cells are MHC class I proteins found on?
On all cells.
When an MHC class II protein is bound to an antigen, what does it do?
Interacts with Th cells.
What is TCR?
T cell receptor.
What does a TCR do?
A TCR (T cell receptor) is used by T cells to interact with antigens displayed by MHC.
What is used by T cells to interact with antigens displayed by MHC?
TCR (T cell receptor)
What are CDs?
Clusters of differentiation
What are clusters of differentiation (CDs) used for and what are the types?
CDs are co-receptors that help T cells distinguish between MHC I and II proteins.
CD4 and CD8
What is CD4 used for?
CD4 is a cluster of differentiation that is found on Th cells to distinguish MHC class II cells.
What cluster of differentiation is found on Th cells to distinguish MHC class II cells?
CD4
What is CD8 used for?
CD8 is a cluster of differentiation that is found on Tc cells and recognizes MHC class I proteins.
What type of cluster of differentiation is found on Tc cells and recognizes MHC class I proteins?
CD8
Th are what?
T helper cells
What do T helpers do?
Th cells recognize an antigen presented by an APC on an MHC class II protein.
What type of cell recognizes an antigen presented by an APC on an MHC class II protein?
T helper
What do cytotoxic T cells do?
Tc cells recognize an antigen presented by an APC on an MHC class I protein (all cells).
What cells recognize an antigen presented by an APC on an MHC class I protein (all cells)?
Cytotoxic T cells (Tc)
What do activated T helper cells do?
Divide and differentiate into several cell types, including memory cells.
What type of T cell when activated divides and differentiate into several cell types, including memory cells?
T helper cells