Exam III: PK in Cirrhosis Flashcards
1
Q
Cirrhosis leads to a ______ in liver blood flow. What type of drugs does this affect the most?
A
Decrease in liver blood flow.
Affects High-First pass drugs the most resulting in higher concentrations.
Examples)
Propranolol
Morphine
Coreg
2
Q
Which phase of metabolism is affected more significantly by cirrhosis?
A
Phase I metabolism
3
Q
Diazepam is metabolized by _____, while lorazepam is metabolized by _____/
A
Diazepam = CYP
Lorazepam = Phase II
4
Q
In cirrhosis albumin production ________.
A
Decreases
5
Q
What drug can we monitor the unbound concentration of in cirrhosis?
A
Phenytoin
6
Q
Renal function _____ in cirrhosis
A
Decreases
7
Q
The therapeutic response to CNS agents _______ in cirrhosis.
A
Increases due to increased permeability of the blood-brain barrier.
