Exam III : DDI (Anderson)

Question 1

Digoxin and Omeprazole

Answer 1

Digoxin: P-glycroprotein dependent absorption (60-80%), Feces (3-5%)

Omeprazole: CYP2C19 inhibitor, increase GI pH

*21% increase in AUC of digoxin = risk rating B (no action needed, increase within acceptable range of bioequivalence)

Question 2

Antacids can _____ the rate/extent of absorption

Answer 2

Atenolol, ciprofloxacin, enoxacin, isoniazid, ketoconazole, norfloxacin, ofloxacin, tetracycline

Question 3

Proton Pump Inhibitors & H2-blockers _____ gastric pH and _____ absorption of weak acids and ______ absorption of acid-labile and weak basic drugs

Answer 3

Proton Pump Inhibitors & H2-blockers increase gastric pH and decrease absorption of weak acids and increase absorption of acid-labile and weak basic drugs

Question 4

Food usually ____ rate of absorption. Effect of food on prolonged release products are ____ in females than in males.

Answer 4

Food usually decreases rate of absorption. Effect of food on prolonged release products are greater in females than in males.

Question 5

Broad-spectrum inducers: CYP1A2, CYP2C, CYP3A, UGTs

Answer 5

Carbamazepine, phenytoin, phenobarbital, rifampin

Question 6

Broad-spectrum inducers: CYP2C19, CYP3A4, p-gp

Answer 6

St. John’s Wort

Question 7

Selective UGT inducers

Answer 7

Lamotrigine, oxcarbazepine, OC (via ethinyl estradiol)

Question 8

Selective CYP1A2 inducer

Answer 8

Tobacco, marijuana

Question 9

Selective CYP2E1 inducer

Answer 9

Ethanol, isoniazid

Question 10

CYP2C9 Inhibitor

Answer 10

Amiodarone, fluconazole, metronidazole, voriconazole

Question 11

CYP2C9 substrate

Answer 11

Phenytoin, s-warfarin

Question 12

CYP2C19 Inhibitor

Answer 12

Cannabidiol, cimetidine, fluoxetine, fluvoxamine, omeprazole, voriconazole

Question 13

STRONG CYP2D6 Inhibitor

Answer 13

Fluoxetine, paroxetine, bupropion, quinidine, ritonavir

Question 14

MODERATE CYP2D6 inhibitor

Answer 14

Sertraline, duloxetine, terbinafine

Question 15

CYP3A4 Inhibitor

Answer 15

Amiodarone, clarithromycin, erythromycin, ketoconazole, verapamil, voriconazole, grapefruit juice