EXAM III Flashcards
1
Q
Define avidity
A
The Ag-Ab complex strength
High avidity has high number of binding sites = effective at neutralizing
i.e. IgM - low affinity, but high avidity
2
Q
Define Valency
A
The max number of Ag determinants
High valency = high affinity
i.e. monovalent, bivalent, multivalent
3
Q
What results when cleaving an Ag with Papain?
A
Cleaves above the hinge region (above pepsin)
2 Fab fragments
1 Fc fragment
4
Q
What results when cleaving an Ag with Pepsin?
A
Cleaves below the hinge region (below papain)
Fc portion gets degraded
Single bivalent Ab-binding Fab fragment
5
Q
What is the receptor for transferring maternal IgG to fetal circulation?
A
FcRNm
