Exam II Review Flashcards
Category A drug recommended in pregnancy and what does it do?
Folic Acid
Prevents NT defects
Which of the anticonvulsants can be used in pregnancy?
Levetiracetam
Lamotrigine
Clonazepam
Gabapentin
Which of the anticonvulsants cannot be used in pregnant?
Valproate
NEVER EVER EVER
Is heparin or warfarin recommended in pregnancy?
Heparin
What are the potential side effects of phenytoin, phenobarbitone?
Fetal hydrantoin syndrome - cleft lip, palate; congenital heart disease, slowed growth, mental deficiency
What are the risks of carbamazepine and topiramate in pregnant women who take these medications as anticonvulstants?
craniofacial anomalies
developmental delay
intellectual disabilties
What happens when you give valproate to a pregnant woman?
NT defects
dev. delay
endocrine disorders
limb defects
nerudevelopment issues
What drug should be avoided in pregnancy that is used to treat hep C and RSV?
Ribavirin
What happens when women take isotretinoin?
birth defects - hydrocephaly, microcephaly, intellectual disability, ear and eye abnormalities, cleft lip and palate and ehart defects
What was thaliddomide used for and why on orphan drug status?
nausea in pregnancy
damages DNA through oxidative stress and causes multiple limb deformtities
Abnormalities assoc with warfarin?
saddle nose
depressed nasal bridge
leading preventable cause of intellectual disability
fetal alcohol syndrome
What drug is assoc with increased risk to the fetus years later of adenocarcinoma of the vagina or cervix?
DES exposure - this shows us that not every birth defect will be visible right away
What type of receptor and what is it involved in?
activates NO and vasodilation in endothelium
encourages wakefulness and appetite control in the brain
acts through Gq
H1 histamine response receptor
What receptor and what is it involved in?
Gs coupled, increased cAMP
gastric acid secretion
heart brain, mast cells
can cause vasodilation
H2 histamine receptor
allergic reaction
