Exam II: Phase II Enzymes

Question 1

two enzymes of glucuronidation?

Answer 1

UGT1 & UGT2

Question 2

function of glucuronidation?
what does it add?

Answer 2

make compound larger

usually looks like a ring with OH on every carbon in ring with one COOH group

Question 3

two most important sulfonation enzymes?

Answer 3

SULT1 and SULT2

Question 4

what does sulfonation look like?

Answer 4

addition of sulfur group to structure bound with oxygen

Question 5

Carboxylic acid substrate is activated with ATP and coenzyme A (CoA) to form an:

Answer 5

acyl-CoA complex

Question 6

describe methylation

Answer 6

transfers methyl group to N, O, or S atoms

dec water solubility

Question 7

what is COMT

Answer 7

methylation enzyme that only acts on catechols (2 adjacent hydroxyl groups)

Question 8

what is PNMT

Answer 8

methylation enzyme, acts on N atoms

Question 9

what is TPMT

Answer 9

methylation enzyme, acts on sulfur atoms

Question 10

two enzymes of N-acetylation?

Answer 10

NAT1 and NAT2

Question 11

what does N-acetylation do?

Answer 11

adds acetyl group (N-C-CH3 + double bond O) onto N

Question 12

which drugs are administered as racemic mixtures?

Answer 12

warfarin, propranolol, hexobarbital, ibuprofen,glutethimide