Exam I - Ventricles, Meninges and Blood Brain Barrier Flashcards
Dev. of Ventricular System:
Cavity of neural tube develops into? and ultimately into?
Choroid plexus does what?
Cavity of neural tube – neural canal – ultimately gives rise to ventricles and central canal of the spinal cord.
Choroid plexus – secretes cerebrospinal fluid (CSF) – fills ventricles and subarachnoid space - from tufts of cells in first trimester
Dev. of Ventricular System:
Interventricular foramen location?
Cerebral aqueduct location?
Interventricular foramen – (of Monroe) – Between LV and third ventricle..
Cerebral aqueduct – between Third and fourth ventricle.
Foramen of Lushka and Magendie – develops when? With what do they communicate and how?
Foramen of Lushka and Magendie – after first 2-3 months of development.
Openings form in 4th ventricle that allow communication with subarachnoid space.
CSF Circulation:
CSF released from ___, travels through ___and out through ____.
Enters the ____ and circulates around brain and spinal cord.
CSF enters the vascular system through the ____.
CSF released from choroid plexus, travels through ventricles and out through foramen.
Enters the subarachnoid space and circulates around brain and spinal cord.
CSF enters the vascular system through the arachnoid villa.
MENINGES:
Dura Mater is what? Describe it in:
Brain ?
Spinal Cord ?
Arachnoid Membrane in…
Brain?
Subarachnoid space?
Spinal Cord?
Pia Mater in…
Brain?
Spinal Cord?
Dura Mater: brain – adherent to skull (no epidural space).
Spinal Cord – separated from vertebrate by epidural space.
Arachnoid Membrane:
Brain - arachnoid villa – allow CSF to flow to the blood.
Subarachnoid space is filled with CSF.
Spinal Cord – no arachnoid villa.
Pia Mater:
Brain – adherent to surface of brain.
Spinal Cord – adherent to surface.
Pial specializations.
What are the meninges and why are they important?
Membranous coverings surround the central nervous system - encased in skull and vertebral column.
Protect the brain and spinal cord.
Support for arteries, veins and sinuses.
Enclose the subarachnoid space – vital for brain survival.
Dev. of meninges:
Meninges develop from? When?
Meninges develop from cells of the neural crest and mesoderm.
Surround neural tube approx 20-35 days gestation.
BBB:
What is it/made of?
Specializations of the walls of the brain capillaries that limit the flow of various ions, drugs etc into extracellular space.
Endothelial cells surrounded by basal lamina.
BBB: important functions? Uptake is mostly a function of?
c
Circumventricular Organs - What does this mean?
what are they? (5) What are their functions?
Circumventricular Organs:
- Pineal body (gland) – melatonin and circadian rhythms.
- Area postrema – vomiting center (caudal portion of 4th ventricle).
- Subfornical organ – important for regulation of body fluids.
- Vascular organ of the lamina terminalis (OVLT) – chemosensory area.
- Median eminence – anterior pituitary hormones.
