EXAM I Flashcards
How many pairs of spinal nerves are there?
31
Two main subdivisions of the nervous system
Somatic and visceral (autonomic)
Where do the cell bodies of somatic sensory neurons lie?
In the PNS in the dorsal root ganglion
Which neuron’s axon is longer in the sympathetic division, preganglionic or postganglionic?
Postganglionic
Which neuron is longer in the PSNS, pregang. Or postgang?
Preganglionic
What neurotransmitter is released from SNS postganglionic neuron
Norepinephrine
What splanchnic nerves are parasympathetic?
Pelvic
Where are visceral afferent cell bodies located?
DRG or cranial nerve ganglion
What CNs are special sensory?
I, II, VII, VIII, IX, X
What CNs are motor?
III, IV, V, VI, VII, IX, X, XI, XII
What is the largest CN?
Trigeminal
Smallest CN?
Trochlear
What CNs exit the superior orbital fissure?
III, IV, V1, VI
What CNs exit the internal acoustic meatus?
VII and VIII
What CNs exit the jugular foramen?
IX, X, XI
Two types of upper motor neurons and where they can be found?
Pyramidal: in the cortex
Extrapyramidal: found in the brainstem
Where do pyramidal fibers synapse?
Rexed lamina 7 and 9
Where do extrapyramidal UMNs synapse?
Rexed lamina 7, brainstem and CN nuclei
Where are cell bodies of LMNs located?
Rexed lamina IX and CN nuclei of origin
How many neurons in the somatic sensory pathway?
3
Where are first order neurons in the somatic sensory pathway located?
DRG and synapse in the spinal cord
Where do second order sensory neurons terminate?
Thalamus, after decussating
Where do third order sensory neurons relay information to?
From thalamus to cerebral cortex (post central gyrus mostly)
Where are olfactory neurons found?
In the superior nasal cavity in the superior nasal concha only
What are the receptors of olfactory neurons called?
Olfactory hairs
Are olfactory neurons axons myelinated?
No, but are covered by schwann cells
What is the path of olfactory neurons?
They enter through the cribiform plate, go through the olfactory bulb and synapse on mitral cells
What are found at the synapses between olfactory neurons and mitral cells?
Synaptic glomeruli
Where do fibers from the medial olfactory stria go?
Cross the midline via the anterior commissure and travel to the opposite olfactory bulb
Where do lateral olfactory stria fibers go?
Carry info to the primary olfactory cortex (periamygdaloid and prepiriform area, including the uncus) broadman area 34
How many neurons in the olfactory pathway?
2
Is smell segregated into right and left?
No
Why is the sensory olfactory pathway only a 2 neuron pathway?
Mitral axons do not go through the thalamus, go straight to the cortex
What sign is associated with CSF leakage?
Halo sign (CSF)
What nerve is poorly developed in humans and was important for tracking prey?
Vomeronasal nerve
Three tunics of the eye and what they consist of….
Fibrous tunic (outer): sclera and cornea Vascular tunic (middle): ciliary body, iris and choroid Retina (inner): 10 layers (know diagram page 174)
Three types of cones
Red, green and blue
What is required for cones to function and where are they most concentrated?
Require light, and concentrated on the center of the retina (fovea)
What layer are bipolar cells found in?
The inner nuclear layer
What layer is the synapse between bipolar and ganglion cells?
Inner plexiform layer
Where do ganglion cells lead?
Information is conveyed in the nerve fiber layer toward the optic disc, axons are carried in the optic nerve after leaving the eye
Are optic nerve axons myelinated?
Yes, not myelinated in the retina until they leave the eye
What cells form the myelin on CN II?
Intrafascicular oligodendrocytes
What fibers from the eye from CN II will decussate?
Fibers from the medial side of each retina
Where does the CN II fibers terminate?
One of three nuclei: lateral geniculate body (MC) and relayed to cortex in the occipital lobe (Bdmn 17), superior colliculus and relayed to tectospinal tract, or pretectal nucleus of the midbrain
What muscles are innervated through tectospinal tract?
SCM and trapezius
How many neurons in the vision pathway?
4
Lesion of the optic nerve would cause:
Smaller field of vision, loss of depth perception
Loss of the optic chiasma would cause?
Tunnel vision
Loss of an optic tract would cause?
Loss of right or left visual field
How to test direct and consensual light reflex
Flashlight
How does the eye change for an accommodation reflex?
Changing the shape of the lens
How to test corneal reflex
Touch the cornea and the eye will shut
What is the convergence reflex?
The eyes move together
What extraoccular muscles does CN III supply?
All except superior oblique and lateral rectus
Where do oculomotor nuclei originate?
Periaqueductal grey, anterior to cerebral aqueduct
What part of the cortex sends axons to the oculomotor nuclei?
BDMN 8
Where else does the CN III nuclei receive fibers from?
Superior colliculus and medial longitudinal fasciculus
Where does CN III exit the CNS?
Interpeduncular fossa
Where does CN III go after it penetrates the dura?
Travels along the cavernous sinus and exits the skull through the superior orbital fissure. Then splits into superior and inferior rami in the eye socket.
Muscles supplied by the superior ramus of CN III
Superior rectus
Levator palpebrae superioris
Muscles supplied by inferior ramus
Medial rectus: medial branch
Inferior rectus: central branch
Inferior oblique: lateral branch
What is contained in the accessory oculomotor nucleus? Where do these fibers go?
Preganglionic Parasympathetic neurons. These fibers follow the oculomotor nerve and synapse in the ciliary ganglion
Where is the ciliary ganglion located?
Posterior to the eyeball 1 cm anterior the SOF
Where do postgang parasymp fibers go after they leave the ciliary ganglion? What do they supply?
Follow ciliary arteries and pierce the sclera (know schematic page 179)
Supply:
Ciliaris
Sphinter pupillae
Are fibers exiting the oculomotor nuclei UMN or LMN?
LMN because axons extend into the PNS
Muscle supplied by trochlear nerve
Superior oblique muscle
Where is the trochlear nucleus located?
Periaqueductal gray caudal to oculomotor nuclei
What part of cerebral cortex sends axons to the trochlear nucleus?
BDMN 8
Where else does does the trochlear nucleus receive axons from?
Superior colliculi and medial longitudinal fasciculus
What is the course of CN IV when is exits the CNS?
Curves around the brainstem and continues in the lateral wall of the cavernous sinus. Enters the orbit throught the SOF and supplies superior oblique.
How to test trochlear nerve destruction
Have patient look down. NOT down and out because other muscles will be involved
What muscle does the abducens nerve supply?
Lateral rectus
Where is the abducens nucleus located?
Caudal part of the pons, at floor of the rhomboid fossa.
How do axons from the abducens nucleus exit the CNS?
Axons project anteriorward and exit CNS at the border of the pons
What type of fibers do the trochlear and abducens nerves use to communicate with the cavernous plexus?
Sympathetic
Where does the abducens nerve travel after it penetrates the dura?
Travels along the cavernous sinus and exits skull through the SOF, innervates lateral rectus
What is strabismus?
Eyes are not pointing at the same thing (think Steve Buscemi’s character from Mr. Deeds)
Internal strabismus vs external strabismus?
Internal: eyes cross (converge)
External: eyes diverge
Diplopia definition
Double vision from an alignment problem or processing error. Difficult to demonstrate objectively