Exam I

Question 1

Substances intended for use in curing, treating, mitigating, diagnosing, or preventing disease.

Answer 1

Drugs

Question 2

The product by which a drug is given or administered. (e.g. tablets, capsules, ointments, etc)

Answer 2

Drug dosage form (drug product)

Question 3

The release of the drug substances from the drug product.

Answer 3

Drug performance

Question 4

Biopharmaceutics examines the interrelationship of what three things?

Answer 4

1. Physical/chemical properties of the drug
2. dosage form
3. rate and extent of absorption

Question 5

Repulsive and attractive forces are equal, potential energy is minimum, and the system is most stable at __ to __ angstroms.

Answer 5

3 to 4

Question 6

Nonionic interaction or charge-charge interaction between molecules

Answer 6

Van der Waals forces

Question 7

Are Van der Waals forces strong or weak?

Answer 7

weak

Question 8

Involves a dispersion of charge across a molecule called dipole or permanent dipole

Answer 8

Van der Waals forces

Question 9

Three types of van der waals forces:

Answer 9

1. Keesom
2. Debye
3. London

Question 10

Type of force that arises due to differences in electronegativity (e.g. peptide bond)

Answer 10

Permanent dipole

Question 11

Force between two permanent dipoles when interacting with one another in an ion-like fashion.

Answer 11

Keesom forces

Question 12

Ability of a permanent dipole to polarize charge in neighboring molecule

Answer 12

Debye forces

Question 13

Two neighboring neutral molecules induce partial charge distribution

Answer 13

London forces

Question 14

Interaction between the pi-electron orbitals in a system.

Answer 14

Orbital overlap

Question 15

Attraction forces that occur between polar or non-polar molecules and ions

Answer 15

Ion-Dipole and Ion-Induced Dipole Forces

Question 16

Cause the solubility of crystalline substances in water (cation attracts negative O and anion attracts positive H)

Answer 16

Ion-dipole interaction

Question 17

Force involved in the formation of the iodid complex

Answer 17

Ion-induced dipole forces

Question 18

Interaction that has effect on physical properties of pharmaceutical agents.

Answer 18

Ion-ion interaction

Question 19

Interaction between a molecule containing a hydrogen atom and a strongly electronegative atom.

Answer 19

Hydrogen bond

Question 20

When solids pass directly from solid to gaseous phase without melting at room temperature.

Answer 20

Sublimation

Question 21

When gases pass directly from gaseous phase to solid phase.

Answer 21

Deposition

Question 22

Dehydration process where the water is removed from solid state to vapor state using sublimation.

Answer 22

Lyophilization

Question 23

How does lyophilization (freeze drying) work?

Answer 23

Reduced pressure

Question 24

Can the liposome structure break?

Answer 24

Yes

Question 25

How does the liposome structure break?

Answer 25

Temp, pH, changing solvent, etc

Question 26

``` Which of the following is not charge-charge interaction? Keesom forces Debye forces Hydrogen bond London forces ```

Answer 26

Hydrogen bond

Question 27

Transfer of material from gaseous state to solid state is defined as:

Answer 27

Deposition

Question 28

Term used to describe the different crystalline forms of a drug substance.

Answer 28

Polymorphs

Question 29

Cortisone acetate has __ polymorphic forms

Answer 29

5

Question 30

Ranitidine Hcl has __ polymorphic forms

Answer 30

2

Question 31

Mizolastine has __ polymorphic forms

Answer 31

3

Question 32

Carbamazepine has __ polymorphic forms and ___

Answer 32

2; dihydrate

Question 33

Use of nanoparticles in technology

Answer 33

Nanotechnology

Question 34

One of the major characteristics on nanoparticles is what?

Answer 34

Enhanced surface area

Question 35

What makes up a solution?

Answer 35

A solute and a solvent

Question 36

What is the minor component in a solution (e.g. drug substance)

Answer 36

Solute

Question 37

What is the major component of a solution (e.g. water, dissolution media)

Answer 37

Solvent

Question 38

A homogenous mixture containing two or more components is what?

Answer 38

A solution

Question 39

Moles of solute in 1 liter of soltuion

Answer 39

Molarity

Question 40

Gram equivalent weight of solute in 1 liter of solution

Answer 40

Normality

Question 41

Moles of solute in 1000 g of solvent

Answer 41

Molality

Question 42

Ratio of the moles of one constituent of a solution to the total moles of all constituents.

Answer 42

Mole fraction

Question 43

Gram of solute in 100g of solution

Answer 43

Percent by weight (w/w)

Question 44

Mililiters of solute in 100 mL of solution

Answer 44

Percent by volume (v/v)

Question 45

Grams of solute in 100 mL of solution

Answer 45

Percent by weight-in-volume (w/v)

Question 46

Atomic weight divided by the valence

Answer 46

Equivalent weight

Question 47

Solution which has no change in properties of the constituents other than dilution, when they are mixed to form the solution.

Answer 47

Ideal solution

Question 48

A solution which has a change in properties of its constituents such as volume, heat when mixed.

Answer 48

Real solution

Question 49

In an ideal solution, the partial vapor pressure of each volatile component is equal to the vapor pressure of the pure constituent multiplied by its mole fraction in the solution.

Answer 49

Roult's Law

Question 50

A-A, B-B, and A-B interactions are equal.

Answer 50

Roult's Law

Question 51

A-B interactions stronger than A-A or B-B interactions.

Answer 51

Negative deviation from Roult's Law

Question 52

A-B interactions weaker than A-A or B-B interactions

Answer 52

Positive deviation from Roult's Law

Question 53

The temperature at which the vapor pressure of the liquid equals the pressure surrounding the liquid.

Answer 53

Boiling point