Exam Flashcards

1
Q

CT

A

Computed tomography uses a computer to process information collected from the passage of x-ray beams through the area of anatomy. The radiation will hit a detector after passing through a patient. Image reconstruction from projections.
Each CT slice represents a specific plane in the patient’s body
The thickness of the plane is referred to as the Z-axis. The Z-axis determines the thickness of the slice.

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2
Q

Slip ring technology

A

Before helical scanning systems, there was high tension cable that had to be wound and unwound as images were being taken. Slip rings fix this problem.
Data gathering system using a continuous rotation of the x-ray source.
With a slip ring, the x-ray source can reach much higher speeds and decrease the acquisition time.

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3
Q

Multi-slice CT (MSCT)

A

Uses multiple rows of detectors in conjunction with widening the x-ray beam in the Z direction. May contain between 4 and 64 rows.
Allows for data to be collected from more than once slice at a time
Certain rows of the detectors can be selected to change the slice thickness along with the collimator.
Advantages:
- faster scanning due to wider total active detector width
- better dynamic imaging due to faster scanning times
- thinner slices
- 3D imaging which is enabled by thin slices
- simultaneous acquisition of more than one slice
Detector no longer collects the penumbra only the central beam

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4
Q

Grayscale

A

There are more than 2000 Hounsfield units.
The monitor can display 256 of those.
The human eye can only see about 40.

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5
Q

Imaging system

A
Produces x-rays 
Shapes & filters (hardens) beam
- collimates
- attenuates for uniformity
Provides digital intensity data to the computer
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6
Q

Filter purpose

A

Protects patient from low-energy photons.
Provides beam closer to mono-energetic
The purpose of filtration is to provide a more uniform beam

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7
Q

Collimation purpose

A

To ensure constant beam width at the detector

Determines the thickness of the slice

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8
Q

Types of detectors

A
Scintillation Detector (solid-state): photodiode is attached to the crystals and transforms the light energy into electrical (analog) energy
Gas ionization detector: these ions are accelerated by the high voltage on the detector plate
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9
Q

Data acquisition system (DAS)

A

Detector & electronics
Includes analog to digital converter, provides digital information to the reconstruction computer
Positioned within the gantry near the detectors.
Reads each arriving ray and measures how much beam is attenuated.

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10
Q

Attenuation coefficient

A

Reflects the degree to which the x-ray intensity is reduced by the material it passes through.

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11
Q

Reconstruction

A

The process of summing up all the attenuation data from thousands of angles.
When raw data are manipulated to create pixels that are used to create an image.

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12
Q

Hounsfield units

A

Air = -1000 HU
Water = 0HU
Bone = 1000 HU
Bone appears white, gasses and liquids are black and tissue is grey.

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13
Q

Tomographic images

A

Is a picture of a slice of the patient’s anatomy.
The 2D array of pixels in the CT images corresponds to an equal number of 3D voxels in the patient.
Each pixel on the CT image displays the average x-ray attenuation properties of the tissue in the corresponding voxel.

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14
Q

Ray

A

Single transmission measurement through the patient made by a single detector at a given moment in time.

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15
Q

Projection or view

A

A series of rays that pass through the patient at the same orientation

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16
Q

Two projection geometries

A

Parallel beam geometry with all rays in a projection parallel to one another
Fan beam geometry: in which rays at a given projection angle diverge.

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17
Q

Localizer scan (scout)

A

Most CT studies begin with one or more localizer scans.
Used to prescribe location of cross-sectional slices. Determined by the area being scanned with anatomical landmarks that can be readily identified.
Also need to select the optimal field of view and image center.
Similar to images captured with conventional radiographic projection technique.
- with slightly poorer image quality and deliver the same amount of dose.
The position of the tube determines the orientation of the patient.
- tube positioned above patient an AP image will be acquired
- tube positioned to side a lateral image will be acquired
The optimal localizer scan includes all areas to be scanned.
- anatomy to be images must be placed within the scannable range (z-direction)
- the patient must also be centred in the x and y-direction

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18
Q

Step and shoot scanning (conventional)

A

Scan method in which the CT table moves to the desired location and remains stationary while the x-ray tube rotates within the gantry collecting data.
Scans produced with a step-and-shoot method result in images that are perpendicular to the z-axis and parallel to every other slice.
Main disadvantages:
- interscan delay: the cumulative effect of the pauses between each data acquisition adds to total exam time.
- slice to slice misregistrations

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19
Q

Helical scanning

A

Produces slices in which the beginning point and the end point are not in the same Z axis
Key aspects:
- continually rotating x-ray tube
- constant x-ray output
- uninterrupted table movement
Eliminates the interscan delay
Advantages:
-ability to optimize iodinated contrast agent administration
- reduces respiratory misregistration
- reduces motion artifacts from organs
- pitch > 1 can be used to reduce scan time and/or radiation dose and still cover the same volume

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20
Q

Single detector row system

A

Each detector element is quite wide in the z-direction. Opening and closing the collimator controls the slice thickness by controlling the portion of the width of the detector that is exposed.
Detector collects both the primary beam and the penumbra zone radiation.

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21
Q

X-ray tube

A

The focal spot is the area of the anode surface which receives the beam of electrons from the cathode.
Modulation of focal spot (FS) size:
- small FS: thinner slices and increased resolution
- larger FS: increased power, larger volume scans with increased soft-tissue contrast

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22
Q

Bowtie filters

A

The purpose is to taper the radiation profile - fewer x-rays are emitted in regions where the body part is thinner.

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23
Q

Scatter grids

A

Created due to MDCT have increased scatter due to large beam widths. Scatter grids reduce scatter and preserve the contrast to noise ratio. Placed in front of the detector and focused on optimal alignment with the x-ray primary beam.

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24
Q

Helical pitch (SDCT)

A

The parameter that describes the CT table movement during helical acquisition.
The travel distance of the CT scan table per 360 degrees rotation of the x-ray tube, divided by the collimation width.
- table feed = colimation the pitch = 1
- table feed < beam collimation the pitch < 1 and scan overlaps occurs.
- table feed > beam collimation the pitch > 1 and scan gaps occur
As the pitch increases so does the slice angle. More interpolation is required to straighten the image.
Increasing the pitch will result in a scan covering more anatomy lengthwise, it will reduce the radiation dose to the patient.
Decreasing the pitch slows down the table speed and decreases the anatomy covered, this will increase the radiation dose to the patient.

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25
Pitch in MDCT
With MDCT the terms collimation and slice thickness are no longer synonymous. Pitch is defined as table movement per rotation divided by beamwidth. Beamwidth is determined by multiplying the number of slices by the slice thickness. Pitch = table speed/(# of slice x slice thickness) The patient dose is proportional to 1/pitch. So pitch values greater than one decrease patient dose. A pitch of less than one increases the dose.
26
Scan field of view (SFOV)
Determines the area within the gantry from which raw data is required. Is in the isocenter of the gantry. Determines the number of detector cells collecting data. Anything outside of the SFOV is not scanned. To produce the highest quality image select the SFOV that comes closest to encompassing the patient. Parts of the patient outside of the SFOV may cause out-of-field artifacts in the image.
27
Display field of view (DFOV)
Determines how much of the collected raw data are used to create an image. Also called zoom or target. Changing the DFOV affects image quality by changing the pixel size. DFOV cannot be larger than the SFOV Choosing the optimal DFOV improves the detectability of abnormalities. - to large makes anatomic structures unnecessarily small - to small may exclude important patient anatomy.
28
Algorithims
Are a finite set of unambiguous steps performed in a prescribed sequence to solve a problem.
29
Fourier transform
Image processing tool that decompresses an image into components
30
Interpolation
is a mathematical method of estimating the value of an unknown function using the known value on either side of the function.
31
Image reconstruction: major components
Hardware: parts of the computer that can be physically touched - hard disk - input devices - output devices - central processing unit Software: instructions that tell the computer what to do and when to do it.
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Image reconstruction
Using raw data to create an image.
33
Prospective reconstruction:
Automatically produced during scanning.
34
Retrospective
Refers to using the same raw data later to create a new image
35
Ray sum/view
The DAS reads each arriving ray and measures how much of the beam is attenuated. Many ray sums at various angles make up a view - an attenuation profile is made for each view Many views required for an image
36
Attenuation profile
Created for each view
37
Back projections
The process of information from all attenuation profiles being projected into a matrix. Produces blurred trans-axial images. Different filters can be applied for different purposes: - smooth filters for soft tissue - sharp filters for high-resolution imaging
38
Filter functions
Minimize streaks on the image that result from the back projection. Filtering is done by a series of complicated mathematical steps often referred to as reconstruction algorithm Applying filter function to an attenuation profile is called convolution. Filtered back-projections algorithms use Fourier theory to reduce statistical noise
39
Adaptive Statistical Iterative Reconstruction
New method. Starts with the assumed image computes projections from the image, compares it with original projection data, and updates the image on the basis of the difference between calculated and actual projections. Can reduce image noise. Shown to reduce radiation dose to the patient by as much as 50%
40
Scan parametes
That can be controlled by the operator are: - milliampere (mA) - scan time - kilovolt peak (kVp) - field of view - reconstruction algorithm - pitch
41
Milliamperes and scan time
Together they define the quantity of the x-ray energy Also referred to as tube current. A higher mA setting allows a shorter scan time to be used. It is more common to manipulate the mA's rather than the kVp when modifying the radiation dose. - choice of mA is more flexible - the effect of mA on image quality is more straight-forward and predictable
42
Tube voltage or kilovolt peak
Defines the quality (average energy) of the x-ray beam. | Compared with mA selection, choices of kVp are more limited.
43
Automatic tube current modulation
The software automatically adjusts the mA's to fit the specific anatomic region. Results in 15% to 40% reduction in dose, without degrading image quality.
44
Image quality
Comparison of the image to the actual object. | Directly related to its usefulness in providing an accurate diagnosis
45
Spatial resolution
Also called detail resolution. The ability to resolve (as separate objects) small, high contrast objects. Measured using two different methods: - directly using a line pairs phantom. High contrast line that is separated by an interspace of equal width. - or by data analysis known as the modulation transfer function (MTF).
46
Contrast resolution
The ability to differentiate between objects with very similar densities as their background. CT is superior to all other clinical modalities in its contrast resolution. Measured using phantoms that contain objects of varying sizes and with a small difference in density from the background.
47
Factor affecting spatial resolution
- matrix size - display field of view (decreased FOV improves spatial resolution) - pixel size (decrease pixels improves spatial resolution) - slice thickness (thinner slices --> sharper image) - reconstruction algorithm - focal spot size (large FS decreases spatial resolution, cause more geometric unsharpness, by effect is minimal) - pitch (increased pitch - decrease resolution) - patient motion (blurring, degrades spatial resolution) - scan time (decreased scan time will improve spatial resolution)
48
Factor affecting contrast resolution
- increase mA's = decrease in noise - decrease pixel size = increase in noise - slice thickness, thicker slices allow more photons to reach detectors making it less noisy (at the cost of spatial resolution) - reconstruction algorithm - bone filters decrease contrast resolution - soft tissue filters increase contrast resolution - other - subject contrast: size of object - ingerent contrast: physical properties of the object and its background - displayed contrast - window settings used to display the image
49
Noise
Is an undesirable fluctuation of pixel values in an image of homogenous material. Noise plays an important role in low-contrast resolution. An increased number of photons decreases the noise
50
Quantum mottle
Occurs when there is an insufficient number of photons detected
51
Temporal resolution
How rapidly data are required (time gap between images)
52
Factors affecting temporal resoluation
- gantry rotation speed - number of detector channels in the system - speed at which the system can record changing signals
53
Reformation
When image data are assembled to produce images in different planes or to produce 3D images.
54
Retrospective reconstruction
Parameters that can be changed: - DFOV - image center - reconstruction algorithm - slice incrementation (helical data only) - slice thickness (on MDCT systems only) The images are always in the same plane and the same orientation as were the original images
55
3D reformation
Seeks to represent the entire scan volume in only one image. Manipulate or combine CT values to display an image.
56
Types of 3D reformation
``` Surface rendering (SR) Maximum intensity projection (MIP) Volume rendering (VR) Endoluminal imaging ```
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Surface rendering
Only voxels on the surface of the structure are used. | Replaced with volume rendering.
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Maximum-intensity projection
Selects voxels with the highest value (only see high contrast)
59
Volume rendering
3D semi-transparent representation of the imaged structure. An advantage is that all voxels contribute to the image. Allows the image to display multiple tissues and their relationship to one another. The CT numbers that make up the image are allocated either visible or invisible this displacing the images with varying levels of transparency. Different colours are assigned to ranges of attenuation values such as air, fat, soft tissue & bone Not only provides surface information but also provides detail concerning interior structures.
60
Endoluminal imaging
``` Type of volume rendering that is designed to look at the lumen of a structure. Used to evaluate: - the middle ear - trachea - esophagus - colon (most common) ```
61
Image artifacts
Defined as anything appearing on the image that is not present in the object scanned. Have many different presentations and causes: - physics-based - patient based - equipment induced
62
Beam hardening artifact
Caused by the heterogeneous nature of the x-ray beam used in CT. As an x-ray beam passes through an object, lower energy photons are preferentially absorbed, creating a harder beam. CT systems minimize this in three ways - filtration - calibration correction - beam hardening correction software Can occur when hypodense tissue is next to the hyperdense tissue (brain and skull) Manifest as cupping artifacts or as dark bands or streaks between the dense object in the image.
63
Partial volume artifacts
Due to the scanner being unable to differentiate between a small amount of high-density material or a larger amount of low-density material. Processor tried to average the two densities or structures and information is lost. Can be partially overcome by scanning using thinner slices.
64
Edge gradient effect
Result in streak artifacts or shading arising from irregularly shaped objects that have pronounced differences in densities than surrounding structures. Largely unavoidable but can be reduced by thinner slices, using low HU oral contrast.
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Motion artifacts
Artifacts from patient motion appear as shading, streaking, blurring or ghosting.
66
Metal objects
Metal in the SFOV will create streak artifacts.
67
Out-of-field artifacts
Caused by anatomy that extends outside the selected SFOV. | Appear as streaks and shading image.
68
Ring artifacts
Caused by imperfect detector elements. Appear on the image as a ring or concentric circles. Can sometimes be eliminated by recalibrating the scanner. Probably the most common mechanical artifact.
69
Noise artifact
This appears as graining on the image. | Occur when power supplied to the x-ray tube is insufficient to penetrate the anatomy.
70
Tube arcing
From electrical surges within the x-ray tube. No specific pattern. Can be minor or severe.
71
Spiral and cone beam effect
Helical MDCT systems may experience windmill artifacts. Caused by cone-shaped beam Appear as either streaks or as bright and dark shading near areas of large density differences. Avoidable by using low pitch. More pronounced for the outer detector rows.
72
Density
The degree to which matter is concentrated.
73
PET
Creates an image from radiation given off when positrons encounter electrons in the body. This is done by giving a radiopharmaceutical with a short half-life. The radionuclide emits positrons that encounter electrons in the body and undergo an annihilation event that produces two high-energy photons that can be detected by the imaging device. PET is unique because it creates images of the body's physiological functions, such as blood flow and metabolism. Takes advantage of the metabolism of normal tissue versus disease processes in the body.
74
18-FDG
The most common radiotracer. 18-F is the more commonly used radionuclide. linked to pharmaceutical agents deoxyglucose, which allows for localization that favours glycolysis. Accumulates in cells of high metabolic rates have unstable nuclei. Uptake in the tumour correlates with: - number of viable tumour cells - microvasculature - glucose transporter expression - tumour volume - cell proliferation rate
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Positron
Is the anti-matter partner of an electron
76
Metabolic differences between normal tissue and cancer
- increased glycolysis (rate of glucose, consumption) - increased protein synthesis - more anoxic and hypoxic cells - increased or decreased receptors - increased DNA synthesis - increased blood flow - increased amino acid transport
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Why pet?
- isotopes naturally occurring in elements - high clinical sensitivity & specificity - whole body scan capabilities
78
Importance of specificity in imaging
Survival depends significantly on an early specific diagnosis - early disease assessment - an increased opportunity for prompt treatment
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Sensitivity
Refers to how good a test is at correctly identifying people who have the disease. = True positives/(true positives + false negatives) Low sensitivity would not be a reliable test because of the high false negatives, therefore getting diagnosed for a disease you do not have.
80
Specificity
Concerned with how good the test is at correctly identifying people who are well. = true negative/(true negative + false positive) Low specificity is not reliable because it gives false positives, saying you have the disease when really you do not/.
81
Role of FDG-PET
- detection and staging: functional changes precede anatomical change, which can provide an earlier diagnosis of cancer and more accurate staging. Could impact treatment selection. - monitor response of treatment: can change approach or modality - detection of residual/recurrent disease following definitive treatment, earlier detection of recurrences in asymptomatic patients. - determine benign or malignant - detection of primary unknown - differentiate necrosis, fibrosis vs viable disease - post-treatment: ensure adequate time to avoid false positives due to inflammation.
82
PET precautions
- pregnancy - breastfeeding - diabetes (check serum glucose prior to FDG injection) - kidney failure - contrast allergy
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Patient preparation for PET
- no heavy activity day before the scan - at least 6 hrs fast - hydrate - water during fast and while in the waiting room - pt must rest 45-60 minutes before the scan - plasma glucose levels should be checked prior to injection - empty bladder
84
PET/CT
``` To detect structure and function. Greater detail with higher levels of accuracy because both scans are done at the same time with out the patient having to change position there is less room for error. Advantages: - faster scan times - guided biopsy - one-stop imaging - integration into RT planning ```
85
PET/CT radiotherapy planning
Better patient selection Improves tumour volume delineation - minimize geographic miss - minimize radiation dose to non-target organs Takes into account the metabolic and biological features of cancer - allows targeting &/or dose escalation to hypoxic or other treatment-resistant sub-volumes
86
SPECT
Single-photon emission computed tomography. The patient is injected with gamma-emitting radioisotopes. Similar to CT multiple SPECT scans are performed from various angles then reconstructed into a 3D image. The tracer gets taken up by a very specific site. When the radioisotope decays it emits very specific gamma photons (140 keV) which are detected by crystals and photomultiplier tubes.
87
Common SPECT radiotracers
- Tc-99m (bone, liver, brain) - I-123 (brain) - Ga-67 (lymphoma)
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CT scanners provide patient data on:
- tumour volume in 3D - normal anatomy, including the location of all critical organs - external patient contour - density data for pixel by pixel inhomogeneity corrections
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CT sim principles
- straighten patient - ensure in middle of bore/couch - ensure comfortable/reproducible - decide where best to mark - choose scanning protocol & scan limits - scan
90
IV contrast
Sites: lung, liver, brain, head and neck, gyne, sarcoma Must do a blood test, kidney function test and allergy test Flow rates and scan delays must be taken into account
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GI contrast
Sites: esophagus, stomach, small bowel, large bowel, rectum and anus
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GU contrast
Sites: bladder, gyne
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MRI fusions
``` Gives soft-tissue visibility Site requests: - sarcomas - brain (stereotactic) - spine - gyne ```
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Benefits of brain planning with CT/MRI fusion
- solid casing (skull) - brain tumours difficult to see on CT - also helps delineate normal tissues (optic chiasm)
95
PET/CT
Good fusion with head and neck patients because the patient is in the same set-up position as CT, therefore can accurately delinate GTV.
96
MRI/PET
Allows high spatial resolution and soft-tissue contrast of MRI and sensitivity and specificity of PET.
97
CBCT
Taken of the patient in the treatment position before treatment starts. This done by a kV image system. Obtained in a single rotation of source & detector around the patient. Tomographic reconstruction from a series of 3D radiographs. It is reconstructed then compared to the reference planning CT scan to match the patient's internal anatomy.
98
Registration
The mathematical process of aligning multiple data sets onto a single coordinate system so that the spatial locations of corresponding points coincide.
99
Motion
Anything that may lead to a mismatch between the intended and actual location of the delivered radiation dose.
100
Interfactional motion
Change in patient position between treatment sessions. Patient set-up changes Patient anatomy changes (tumour shrinking, organ fill status)
101
Intrafractional motion
Change in patient position during a treatment session Breathing Gas passing Uncooperative patient
102
Half fan Vs. full fan
``` Full fan: - for small separations (head and neck) - full bowtie filter Half fan: - for large separations (pelvis) - half bowtie filter ```
103
4DCT
Phase-based CT acquisition method that tracks tumour motion Creates a video sequence of the tumour moving throughout the patient breathing cycle. CT takes an over-sampling of images in a given plane. The infrared detector tracks the respiratory phases throughout the image sampling. Images are batched retrospectively into their portion of the breathing cycle.
104
PACS
Picture archiving & communication system A network of computers used by radiology & radiotherapy departments that replaces film with electronically stored and displayed digital images.
105
EHR
Electronic health records | Patients record with multiple doctors and provide a more holistic approach and a long-term view of patients' health.
106
EMR
Electronic medical records Is best understood as a digital version of a patient's chart. It contains the patient's medical and treatment history from practice.