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Bioethics > Exam > Flashcards

Exam Flashcards

1
Q 
This is not a specific pheromone producer gland:
A) gerbil’s umbilical gland
B) rabbit’s face gland
C) dog’s cicumanal gland
D) hamster’s hip gland
A

B) rabbit’s face gland

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2
Q 
Which is not a method for genetic quality control of lab animals?
A) SSLP (micro-sarallite)
B) skin transplantation
C) back gross breeding
D) biomedical markers
A

C) back gross breeding

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3
Q

Drawback of preference tests

A

Animal choose in the base of sort term conditions

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4
Q

Which measurement is used to express energy requirement of laboratory animals?

A

Metabolic body weight

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5
Q

Sentiments are:

A

Animals used to evaluate a group’s health status

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6
Q

Which method would you use to get 1mL of blood from a rat?

A

Cardiac puncture

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7
Q 
You cannot buy this type of diet from a commercial supplier
A) chemical defined diet
B) commercial pellet
C) liquid diet
D) gel
A

A) chemical defined diet

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8
Q 
Not a alpha2-agonist:
A) xylazine
B) detomidine
C) tolmetine
D) romifidine
A

C) tolmetine

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9
Q 
Not inherited disease of rats:
A) deafness
B) diabetes
C) hypoacidosis
D) obesity
A

C) hypoacidosis

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10
Q

The basic method of rodent phenotypic is to look for

A

Chromosome test

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11
Q 
Not part of refinement of animal experimentation:
A) alternatives to animal use
B) genetic homogeneity
C) health status
D) proper defined diet
A

A) alternatives to animal use

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12
Q

Which animals are covered by 63/2010 EEC directive?

A

Vertebrates and cephalopods

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13
Q 
GLP not concerned about conditions under which the laboratory:
A) studies are planned
B) are build
C) research are performed
D) studies are recorded and reported
A

B) are build

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14
Q

Which species can die after oral penicillin treatment

A

Guinea pigs

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15
Q

One of them is an important mechanism of nutrigenomics

A

Changing the signalling pathway

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16
Q

Acute toxicity test has an invasive ness category of —— pain

A

Severe

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17
Q

Maintenance energy requirements of laboratory animals

A

0,45 MJ DE*W0,75

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18
Q 
This disease is not a zoonosis
A) listeriosis
B) salmonellosis
C) lymphatic choriomeningitis of mice
D) ringtail
A

D) ringtail

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19
Q

The recommended nutrient allowances

A

Ensure the reproduction and longevity of the animals

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20
Q 
Cannot be stage of mouse genital and urinary syndrome:
A) ulceration
B) bacteriaemia
C) inflammation
D) mating overload
A

A) ulceration

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21
Q 
Quarantine period not determined by
A) species
B) health status of the animal
C) number of animals
D) purpose of use
A

C) number of animals

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22
Q

Which species has a tied skin, so cannot grab it without causing pain to the animal

A

Guinea pig

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23
Q 
Not physical euthanasia method
A) maceration
B) t61
C) cervical dislocation
D) decapitation
A

A) maceration

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24
Q 
Which species is not a member of rodent is genus?
A) golden hamster
B) marmoset
C) gerbil
D) guinea pig
A

B) marmoset

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25
Q 
OECD do not deal with questions about
A) validation of national laws
B) co-ordination of toxicological databases
C) GLP
D) validation of in vitro methods
A

D) validation of in vitro methods

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26
Q

Gerbil is a good model for

A

Epilepsy, aorta

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27
Q 
The animal cannot be examined with ultrasound
A) golden hamster
B) rabbit
C) guinea pig
D) dog
A

A) golden hamster

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28
Q

Not true for chronic Mycoplasmosis of mice
A) agent is Mycoplasmas pulmonic
B) 12-18 day old puppies are most disposed
C) zoonosis
D) can appear with Sendai virus

A

C) zoonosis

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29
Q

The closest species to Syrian hamster in taxonomy:

A

Gerbil

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30
Q

Good species to use for auditory research

A

Chinchilla

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31
Q 
Breeding technique which is not used to maintain an out bred stock.
A) MAI
B) cross-breeding
C) brother-sister mating
D) random breeding
A

C) brother-sister mating

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32
Q

It can be used for intra-dermal injection

A

Mice ear

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33
Q 
Pasteurella pneumotropica does not attack
A) uterus
B) prostate
C) lung
C) brain
A

C) brain

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34
Q 
Environmental enrichment should not be done:
A) just for human fun
B) for the benefit of the animal
C) with the sense of animals
D) with some unpredictability
A

A) just for human fun

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35
Q

How would you restrain a gerbil

A

Hand around the chest

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36
Q

Who will decide on institute level if an animal experiment was necessary or not?

A

Ethical committee (animal welfare body)

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37
Q 
It is not a zoonosis
A) Sendai virus disease
B) hantaan virus disease
C) salmonellosis
D) lymphocytic-choriomeningitis (LCM)
A

A) Sendai virus disease

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38
Q

This female embryo in a rat will achieve breeding maturity (M=month)

A

1M

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39
Q

The basic method of rodent sexing is to look for

A

And-genital distance

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40
Q

The recommended nutrient allowance

A

Ensure the optimum functioning of the animal

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41
Q

Maintenance energy requirement of laboratory animals and for extrapolation of dosage use

A

W 0,75

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42
Q

The main body of laboratory animal science of the world

A

CLAS

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43
Q

The closest species to Syrian hamster in taxonomy is

A

Gerbil

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44
Q

What “environmental enrichment” means in laboratory

A

To give bedding material or toys to experimental animals if possible

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45
Q

Feeding rancid feed and/or vitamin E deficient feed may cause

A

Dermatitis

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46
Q

Zebradanio is

A

Omnivore

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47
Q

It is an alternative use of animals in experiments

A

Database search and meta-analysis

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48
Q

Sub-cutaneous injury has a severity category of —— pain

A

Minor

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49
Q

Which 3 works called the 3 R’s by Russel and Burch

A

Reduction, replacement, refinement

50
Q

It is not true about euthanasia
A) can be used to get large amount of blood out of an animal
B) must be performed by researchers or other trained person
C) should be used if an animal would suffer in an experiment
D) should be planned in experimental protocol

A

A) can be used to get large amount of blood out of an animal

51
Q

What does “knock out animal” mean

A

Transgenic animal

52
Q

Which method would you use to get a drop of blood from mice

A

Retro-orbital puncture

53
Q

Which name indicates an out bred stock

A

NMRI

54
Q

You cannot use this method for euthanasia on rats:
A) decapitation
B) cervical dislocation with weight limit
C) ketamine
D) CO2

A

C) ketamine

55
Q

What is the best equipment to maintain a transgenic colony in?

A

Base colony in different countries

56
Q

Which species has only provoked (stimulated) ovulation?

A

Ferret

57
Q

What does the expression “inbred strain” mean

A

Brother-sister mating through at least 20 generations

58
Q

Which species is the best in atherosclerosis research

A

WHHL - rabbit

Notes say gerbil

59
Q

You can find a “saccus rotundus” or “ampulla ilei” In the

A

Rabbit

60
Q

This gland is a specific pheromone producer gland

A

Hamster’s lateral gland

61
Q

Which species has a gallbladder

A

Golden hamster

62
Q

What does SPF mean?

A

Specific pathogen free

63
Q

How would you restrain a rat for per-oral dosing

A

By grabbing the skin on back and neck

64
Q

Which sentence is not true about “environmental enrichment”?
A)all possibilities should be done to improve animal’s wellbeing what the experiment allows
Always should be evaluated on cross-benefit base
C) a nest material is an example of that
D) device in case that animal can control

A

D) device in case that animal can control

65
Q

Gnotobiotic animal

A

Germ free

66
Q

What does rederivation mean?

A

Production of form-free strain by embryo transfer

67
Q 
In the practice, it is not possible to produce germ-free colonies from this species
A) duck
B) rabbit
C) rat
D) golden hamster
A

A) duck

68
Q

Which would be the best feeding regime in an experiment

A

Ad libitum

69
Q

What is well-being

A

State of physiological and psychological harmony of the animal with its internal and external environment

70
Q

Which vein can be used for IV injection in ferret

A

Jugular

71
Q

How would you restrain a rabbit

A

By grabbing as much skin as possible on the back

72
Q 
You cannot use this method for euthanasia on newborn, nest-living animals.
A) cutting the neck
B) cervical dislocation
C) electric shock
D) CO2-inhalation
A

D) co2-inhalation

73
Q

Which method would you use to get 10mL of blood from an adult rat

A

Preparation of abdominal aorta

74
Q

Which mouse strain is sensitive to pneumocystis carini?

A

Swiss

75
Q 
Which is not necessary before transport of rodent?
A) fasting
B) clinical examination
C) ear printing
D) acclimatisation
A

A) fasting

76
Q

When this phenomenon disappears, the narcosis ends with death

A

Cornea reflex

77
Q 
It is not trie about euthanasia 
A) it should be cheap
B) it should achieve rapid unconsciousness and death
C) it should be safe for user
D) it should be simple to administer
A

A) it should be cheap

78
Q

One is not true about the co-isomeric strains
A) the new gene is the product of natural maturation
B) it can only be maintained in a homozygous form
C) the name contains the strain/sub-strain and the symbol of the mutant gene
D) the co-isogenic strain differs by only one gene from the original one.

A

B) it can only be maintained in a homozygous form

79
Q 
Dogs is not a good model for
A) leptospirosis
B) tumour-cancer research
C) cardiovascular Artherosclerosis 
D) epilepsy
A

C) cardiovascular Artherosclerosis

80
Q

Mini-pig has a live weight of

A

20-45 kg

81
Q 
Experimental design cannot be
A) cross-over design
B) Latin square design
C) factorial design
D) cross-breeding
A

D) cross-breeding

82
Q

The basal circadian rhythm is

A

Dependent from the gene expression of a protein

83
Q

Melatonin is produced by the

A

Pineal gland

84
Q

This species mostly used in viral respiratory research

A

Ferret

85
Q

A chronic stress can cause this type of behaviour

A

Apathy/aggression

86
Q

Which environment is good for animals?

A

Classical music

87
Q

Which tissue is the least sensitive to suffering

A

Brain tissue

88
Q

The naked mole rat has an extra-ordinary long life span because of

A

Special hyaluronan which prevents cancer

89
Q

The co-efficient on inbreeding

A

Means the fraction of the gene that get fixed in a homozygous state

90
Q

It is inherited disease of some mouse strains

A

Deafness

91
Q

Which is a member of Pox viridae

A

Ectomelia virus

92
Q

Ringtail is caused by

A

Too low relative humidity

93
Q 
Not part of refinement of animal experimentation
A) hair colour
B) health status
C) analgesia
D) environmental enrichment
A

A) hair colour

94
Q

The hearing range of rodents

A

0,5/1-100/120 kHz

95
Q

Which species has 1 pair of teats

A

Guinea pig

96
Q

Which species has a “peg” (double incisors” teeth

A

Rabbit

97
Q

The two important words for animals concerning the pain feeling (Weiss-trail)

A

Predictability and controllability

98
Q

Mouse pox is

A

Caused by ectomelia

99
Q 
It is not a physical euthanasia method
A) t61
B) cervical dislocation
C) decapitation
D) cooling in refrigerator
A

D) cooling in refrigerator

100
Q

The African clawed for

A

Shows mating behaviour after hcg injection

101
Q

The axolotl is not
A) carnivores
B) capable of regenerating lost limbs completely
C) reaches adulthood after a complete metamorphosis
D) has a long life span (8-10 years)

A

C) reaches adulthood after a complete metamorphosis

102
Q

Laboratory animals - except the guinea pig - usually adjust their feeding intake to satisfy their

A

Energy requirement

103
Q

Which species can die after oral antibiotic treatment

A

Rabbit and guinea pig

104
Q

The role of PPAR is to

A

Burn fats

105
Q 
One of the following has no anti-cancer effect
A) iron
B) resveratrol
C) CLA
D) green tea
A

A) iron

106
Q

One of them is an important mechanism of epigenomics

A

Methylation of the dna

107
Q

Zebra fish has a life-span of — years

A

6-8 (internet says 3-5)

108
Q 
One of then has no role in epi-genomics
A) DNA-methylation
B) change of base in DNA
C) sulfurization
D) Histon acetylation
A

B) change of base in DNA

109
Q

The role of — is a fine regulation of the protein synthesis in the cell

A

MiRNA/siRNA

110
Q

In some cases the epi genetic changes may be inherited

A

If the effect acts during the germ-cell proliferation

111
Q

You can find neatens at

A

Axolotl

112
Q

Pheromones are detected by

A

VNO

113
Q

One is true about the ferret

A

We can prevent the constant oestrus by using GnRH agonist implants

114
Q

The cephalopods

A

Are under the protection of the 2010763/EU directive since 2013

115
Q

Always consider using F1 hybrid because

A

MCQ: the answer is neither

116
Q

One of the statements is true

A

Animals in an outbred stock are anisogenic

117
Q

A chromorhnydachyrrhea

A

Vitamin A deficiency

118
Q

It can go through the uterus wall (2 correct)

A

Mouse mammary tumour

LCM

119
Q

Carbohydrates ingestion

A

Stimulate the fatty acid synthase gene expression

120
Q

May increase the mitochondria number

A

Resveratrol

121
Q

The most used model for drug metabolism study for humans

A

Macaco

Bioethics (1 decks)

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