Exam Flashcards
(121 cards)
1
Q
This is not a specific pheromone producer gland: A) gerbil’s umbilical gland B) rabbit’s face gland C) dog’s cicumanal gland D) hamster’s hip gland
A
B) rabbit’s face gland
2
Q
Which is not a method for genetic quality control of lab animals? A) SSLP (micro-sarallite) B) skin transplantation C) back gross breeding D) biomedical markers
A
C) back gross breeding
3
Q
Drawback of preference tests
A
Animal choose in the base of sort term conditions
4
Q
Which measurement is used to express energy requirement of laboratory animals?
A
Metabolic body weight
5
Q
Sentiments are:
A
Animals used to evaluate a group’s health status
6
Q
Which method would you use to get 1mL of blood from a rat?
A
Cardiac puncture
7
Q
You cannot buy this type of diet from a commercial supplier A) chemical defined diet B) commercial pellet C) liquid diet D) gel
A
A) chemical defined diet
8
Q
Not a alpha2-agonist: A) xylazine B) detomidine C) tolmetine D) romifidine
A
C) tolmetine
9
Q
Not inherited disease of rats: A) deafness B) diabetes C) hypoacidosis D) obesity
A
C) hypoacidosis
10
Q
The basic method of rodent phenotypic is to look for
A
Chromosome test
11
Q
Not part of refinement of animal experimentation: A) alternatives to animal use B) genetic homogeneity C) health status D) proper defined diet
A
A) alternatives to animal use
12
Q
Which animals are covered by 63/2010 EEC directive?
A
Vertebrates and cephalopods
13
Q
GLP not concerned about conditions under which the laboratory: A) studies are planned B) are build C) research are performed D) studies are recorded and reported
A
B) are build
14
Q
Which species can die after oral penicillin treatment
A
Guinea pigs
15
Q
One of them is an important mechanism of nutrigenomics
A
Changing the signalling pathway
16
Q
Acute toxicity test has an invasive ness category of —— pain
A
Severe
17
Q
Maintenance energy requirements of laboratory animals
A
0,45 MJ DE*W0,75
18
Q
This disease is not a zoonosis A) listeriosis B) salmonellosis C) lymphatic choriomeningitis of mice D) ringtail
A
D) ringtail
19
Q
The recommended nutrient allowances
A
Ensure the reproduction and longevity of the animals
20
Q
Cannot be stage of mouse genital and urinary syndrome: A) ulceration B) bacteriaemia C) inflammation D) mating overload
A
A) ulceration
21
Q
Quarantine period not determined by A) species B) health status of the animal C) number of animals D) purpose of use
A
C) number of animals
22
Q
Which species has a tied skin, so cannot grab it without causing pain to the animal
A
Guinea pig
23
Q
Not physical euthanasia method A) maceration B) t61 C) cervical dislocation D) decapitation
A
A) maceration
24
Q
Which species is not a member of rodent is genus? A) golden hamster B) marmoset C) gerbil D) guinea pig
A
B) marmoset
25
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OECD do not deal with questions about
A) validation of national laws
B) co-ordination of toxicological databases
C) GLP
D) validation of in vitro methods
```
D) validation of in vitro methods
26
Gerbil is a good model for
Epilepsy, aorta
27
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The animal cannot be examined with ultrasound
A) golden hamster
B) rabbit
C) guinea pig
D) dog
```
A) golden hamster
28
Not true for chronic Mycoplasmosis of mice
A) agent is Mycoplasmas pulmonic
B) 12-18 day old puppies are most disposed
C) zoonosis
D) can appear with Sendai virus
C) zoonosis
29
The closest species to Syrian hamster in taxonomy:
Gerbil
30
Good species to use for auditory research
Chinchilla
31
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Breeding technique which is not used to maintain an out bred stock.
A) MAI
B) cross-breeding
C) brother-sister mating
D) random breeding
```
C) brother-sister mating
32
It can be used for intra-dermal injection
Mice ear
33
```
Pasteurella pneumotropica does not attack
A) uterus
B) prostate
C) lung
C) brain
```
C) brain
34
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Environmental enrichment should not be done:
A) just for human fun
B) for the benefit of the animal
C) with the sense of animals
D) with some unpredictability
```
A) just for human fun
35
How would you restrain a gerbil
Hand around the chest
36
Who will decide on institute level if an animal experiment was necessary or not?
Ethical committee (animal welfare body)
37
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It is not a zoonosis
A) Sendai virus disease
B) hantaan virus disease
C) salmonellosis
D) lymphocytic-choriomeningitis (LCM)
```
A) Sendai virus disease
38
This female embryo in a rat will achieve breeding maturity (M=month)
1M
39
The basic method of rodent sexing is to look for
And-genital distance
40
The recommended nutrient allowance
Ensure the optimum functioning of the animal
41
Maintenance energy requirement of laboratory animals and for extrapolation of dosage use
W 0,75
42
The main body of laboratory animal science of the world
CLAS
43
The closest species to Syrian hamster in taxonomy is
Gerbil
44
What “environmental enrichment” means in laboratory
To give bedding material or toys to experimental animals if possible
45
Feeding rancid feed and/or vitamin E deficient feed may cause
Dermatitis
46
Zebradanio is
Omnivore
47
It is an alternative use of animals in experiments
Database search and meta-analysis
48
Sub-cutaneous injury has a severity category of —— pain
Minor
49
Which 3 works called the 3 R’s by Russel and Burch
Reduction, replacement, refinement
50
It is not true about euthanasia
A) can be used to get large amount of blood out of an animal
B) must be performed by researchers or other trained person
C) should be used if an animal would suffer in an experiment
D) should be planned in experimental protocol
A) can be used to get large amount of blood out of an animal
51
What does “knock out animal” mean
Transgenic animal
52
Which method would you use to get a drop of blood from mice
Retro-orbital puncture
53
Which name indicates an out bred stock
NMRI
54
You cannot use this method for euthanasia on rats:
A) decapitation
B) cervical dislocation with weight limit
C) ketamine
D) CO2
C) ketamine
55
What is the best equipment to maintain a transgenic colony in?
Base colony in different countries
56
Which species has only provoked (stimulated) ovulation?
Ferret
57
What does the expression “inbred strain” mean
Brother-sister mating through at least 20 generations
58
Which species is the best in atherosclerosis research
WHHL - rabbit
| Notes say gerbil
59
You can find a “saccus rotundus” or “ampulla ilei” In the
Rabbit
60
This gland is a specific pheromone producer gland
Hamster’s lateral gland
61
Which species has a gallbladder
Golden hamster
62
What does SPF mean?
Specific pathogen free
63
How would you restrain a rat for per-oral dosing
By grabbing the skin on back and neck
64
Which sentence is not true about “environmental enrichment”?
A)all possibilities should be done to improve animal’s wellbeing what the experiment allows
Always should be evaluated on cross-benefit base
C) a nest material is an example of that
D) device in case that animal can control
D) device in case that animal can control
65
Gnotobiotic animal
Germ free
66
What does rederivation mean?
Production of form-free strain by embryo transfer
67
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In the practice, it is not possible to produce germ-free colonies from this species
A) duck
B) rabbit
C) rat
D) golden hamster
```
A) duck
68
Which would be the best feeding regime in an experiment
Ad libitum
69
What is well-being
State of physiological and psychological harmony of the animal with its internal and external environment
70
Which vein can be used for IV injection in ferret
Jugular
71
How would you restrain a rabbit
By grabbing as much skin as possible on the back
72
```
You cannot use this method for euthanasia on newborn, nest-living animals.
A) cutting the neck
B) cervical dislocation
C) electric shock
D) CO2-inhalation
```
D) co2-inhalation
73
Which method would you use to get 10mL of blood from an adult rat
Preparation of abdominal aorta
74
Which mouse strain is sensitive to pneumocystis carini?
Swiss
75
```
Which is not necessary before transport of rodent?
A) fasting
B) clinical examination
C) ear printing
D) acclimatisation
```
A) fasting
76
When this phenomenon disappears, the narcosis ends with death
Cornea reflex
77
```
It is not trie about euthanasia
A) it should be cheap
B) it should achieve rapid unconsciousness and death
C) it should be safe for user
D) it should be simple to administer
```
A) it should be cheap
78
One is not true about the co-isomeric strains
A) the new gene is the product of natural maturation
B) it can only be maintained in a homozygous form
C) the name contains the strain/sub-strain and the symbol of the mutant gene
D) the co-isogenic strain differs by only one gene from the original one.
B) it can only be maintained in a homozygous form
79
```
Dogs is not a good model for
A) leptospirosis
B) tumour-cancer research
C) cardiovascular Artherosclerosis
D) epilepsy
```
C) cardiovascular Artherosclerosis
80
Mini-pig has a live weight of
20-45 kg
81
```
Experimental design cannot be
A) cross-over design
B) Latin square design
C) factorial design
D) cross-breeding
```
D) cross-breeding
82
The basal circadian rhythm is
Dependent from the gene expression of a protein
83
Melatonin is produced by the
Pineal gland
84
This species mostly used in viral respiratory research
Ferret
85
A chronic stress can cause this type of behaviour
Apathy/aggression
86
Which environment is good for animals?
Classical music
87
Which tissue is the least sensitive to suffering
Brain tissue
88
The naked mole rat has an extra-ordinary long life span because of
Special hyaluronan which prevents cancer
89
The co-efficient on inbreeding
Means the fraction of the gene that get fixed in a homozygous state
90
It is inherited disease of some mouse strains
Deafness
91
Which is a member of Pox viridae
Ectomelia virus
92
Ringtail is caused by
Too low relative humidity
93
```
Not part of refinement of animal experimentation
A) hair colour
B) health status
C) analgesia
D) environmental enrichment
```
A) hair colour
94
The hearing range of rodents
0,5/1-100/120 kHz
95
Which species has 1 pair of teats
Guinea pig
96
Which species has a “peg” (double incisors” teeth
Rabbit
97
The two important words for animals concerning the pain feeling (Weiss-trail)
Predictability and controllability
98
Mouse pox is
Caused by ectomelia
99
```
It is not a physical euthanasia method
A) t61
B) cervical dislocation
C) decapitation
D) cooling in refrigerator
```
D) cooling in refrigerator
100
The African clawed for
Shows mating behaviour after hcg injection
101
The axolotl is not
A) carnivores
B) capable of regenerating lost limbs completely
C) reaches adulthood after a complete metamorphosis
D) has a long life span (8-10 years)
C) reaches adulthood after a complete metamorphosis
102
Laboratory animals - except the guinea pig - usually adjust their feeding intake to satisfy their
Energy requirement
103
Which species can die after oral antibiotic treatment
Rabbit and guinea pig
104
The role of PPAR is to
Burn fats
105
```
One of the following has no anti-cancer effect
A) iron
B) resveratrol
C) CLA
D) green tea
```
A) iron
106
One of them is an important mechanism of epigenomics
Methylation of the dna
107
Zebra fish has a life-span of — years
6-8 (internet says 3-5)
108
```
One of then has no role in epi-genomics
A) DNA-methylation
B) change of base in DNA
C) sulfurization
D) Histon acetylation
```
B) change of base in DNA
109
The role of — is a fine regulation of the protein synthesis in the cell
MiRNA/siRNA
110
In some cases the epi genetic changes may be inherited
If the effect acts during the germ-cell proliferation
111
You can find neatens at
Axolotl
112
Pheromones are detected by
VNO
113
One is true about the ferret
We can prevent the constant oestrus by using GnRH agonist implants
114
The cephalopods
Are under the protection of the 2010763/EU directive since 2013
115
Always consider using F1 hybrid because
MCQ: the answer is neither
116
One of the statements is true
Animals in an outbred stock are anisogenic
117
A chromorhnydachyrrhea
Vitamin A deficiency
118
It can go through the uterus wall (2 correct)
Mouse mammary tumour
| LCM
119
Carbohydrates ingestion
Stimulate the fatty acid synthase gene expression
120
May increase the mitochondria number
Resveratrol
121
The most used model for drug metabolism study for humans
Macaco
