Exam Flashcards
This is not a specific pheromone producer gland: A) gerbil’s umbilical gland B) rabbit’s face gland C) dog’s cicumanal gland D) hamster’s hip gland
B) rabbit’s face gland
Which is not a method for genetic quality control of lab animals? A) SSLP (micro-sarallite) B) skin transplantation C) back gross breeding D) biomedical markers
C) back gross breeding
Drawback of preference tests
Animal choose in the base of sort term conditions
Which measurement is used to express energy requirement of laboratory animals?
Metabolic body weight
Sentiments are:
Animals used to evaluate a group’s health status
Which method would you use to get 1mL of blood from a rat?
Cardiac puncture
You cannot buy this type of diet from a commercial supplier A) chemical defined diet B) commercial pellet C) liquid diet D) gel
A) chemical defined diet
Not a alpha2-agonist: A) xylazine B) detomidine C) tolmetine D) romifidine
C) tolmetine
Not inherited disease of rats: A) deafness B) diabetes C) hypoacidosis D) obesity
C) hypoacidosis
The basic method of rodent phenotypic is to look for
Chromosome test
Not part of refinement of animal experimentation: A) alternatives to animal use B) genetic homogeneity C) health status D) proper defined diet
A) alternatives to animal use
Which animals are covered by 63/2010 EEC directive?
Vertebrates and cephalopods
GLP not concerned about conditions under which the laboratory: A) studies are planned B) are build C) research are performed D) studies are recorded and reported
B) are build
Which species can die after oral penicillin treatment
Guinea pigs
One of them is an important mechanism of nutrigenomics
Changing the signalling pathway
Acute toxicity test has an invasive ness category of —— pain
Severe
Maintenance energy requirements of laboratory animals
0,45 MJ DE*W0,75
This disease is not a zoonosis A) listeriosis B) salmonellosis C) lymphatic choriomeningitis of mice D) ringtail
D) ringtail
The recommended nutrient allowances
Ensure the reproduction and longevity of the animals
Cannot be stage of mouse genital and urinary syndrome: A) ulceration B) bacteriaemia C) inflammation D) mating overload
A) ulceration
Quarantine period not determined by A) species B) health status of the animal C) number of animals D) purpose of use
C) number of animals
Which species has a tied skin, so cannot grab it without causing pain to the animal
Guinea pig
Not physical euthanasia method A) maceration B) t61 C) cervical dislocation D) decapitation
A) maceration
Which species is not a member of rodent is genus? A) golden hamster B) marmoset C) gerbil D) guinea pig
B) marmoset
OECD do not deal with questions about A) validation of national laws B) co-ordination of toxicological databases C) GLP D) validation of in vitro methods
D) validation of in vitro methods
Gerbil is a good model for
Epilepsy, aorta
The animal cannot be examined with ultrasound A) golden hamster B) rabbit C) guinea pig D) dog
A) golden hamster
Not true for chronic Mycoplasmosis of mice
A) agent is Mycoplasmas pulmonic
B) 12-18 day old puppies are most disposed
C) zoonosis
D) can appear with Sendai virus
C) zoonosis
The closest species to Syrian hamster in taxonomy:
Gerbil
Good species to use for auditory research
Chinchilla
Breeding technique which is not used to maintain an out bred stock. A) MAI B) cross-breeding C) brother-sister mating D) random breeding
C) brother-sister mating
It can be used for intra-dermal injection
Mice ear
Pasteurella pneumotropica does not attack A) uterus B) prostate C) lung C) brain
C) brain
Environmental enrichment should not be done: A) just for human fun B) for the benefit of the animal C) with the sense of animals D) with some unpredictability
A) just for human fun
How would you restrain a gerbil
Hand around the chest
Who will decide on institute level if an animal experiment was necessary or not?
Ethical committee (animal welfare body)
It is not a zoonosis A) Sendai virus disease B) hantaan virus disease C) salmonellosis D) lymphocytic-choriomeningitis (LCM)
A) Sendai virus disease
This female embryo in a rat will achieve breeding maturity (M=month)
1M
The basic method of rodent sexing is to look for
And-genital distance
The recommended nutrient allowance
Ensure the optimum functioning of the animal
Maintenance energy requirement of laboratory animals and for extrapolation of dosage use
W 0,75
The main body of laboratory animal science of the world
CLAS
The closest species to Syrian hamster in taxonomy is
Gerbil
What “environmental enrichment” means in laboratory
To give bedding material or toys to experimental animals if possible
Feeding rancid feed and/or vitamin E deficient feed may cause
Dermatitis
Zebradanio is
Omnivore
It is an alternative use of animals in experiments
Database search and meta-analysis
Sub-cutaneous injury has a severity category of —— pain
Minor
Which 3 works called the 3 R’s by Russel and Burch
Reduction, replacement, refinement
It is not true about euthanasia
A) can be used to get large amount of blood out of an animal
B) must be performed by researchers or other trained person
C) should be used if an animal would suffer in an experiment
D) should be planned in experimental protocol
A) can be used to get large amount of blood out of an animal
What does “knock out animal” mean
Transgenic animal
Which method would you use to get a drop of blood from mice
Retro-orbital puncture
Which name indicates an out bred stock
NMRI
You cannot use this method for euthanasia on rats:
A) decapitation
B) cervical dislocation with weight limit
C) ketamine
D) CO2
C) ketamine
What is the best equipment to maintain a transgenic colony in?
Base colony in different countries
Which species has only provoked (stimulated) ovulation?
Ferret
What does the expression “inbred strain” mean
Brother-sister mating through at least 20 generations
Which species is the best in atherosclerosis research
WHHL - rabbit
Notes say gerbil
You can find a “saccus rotundus” or “ampulla ilei” In the
Rabbit
This gland is a specific pheromone producer gland
Hamster’s lateral gland
Which species has a gallbladder
Golden hamster
What does SPF mean?
Specific pathogen free
How would you restrain a rat for per-oral dosing
By grabbing the skin on back and neck
Which sentence is not true about “environmental enrichment”?
A)all possibilities should be done to improve animal’s wellbeing what the experiment allows
Always should be evaluated on cross-benefit base
C) a nest material is an example of that
D) device in case that animal can control
D) device in case that animal can control
Gnotobiotic animal
Germ free
What does rederivation mean?
Production of form-free strain by embryo transfer
In the practice, it is not possible to produce germ-free colonies from this species A) duck B) rabbit C) rat D) golden hamster
A) duck
Which would be the best feeding regime in an experiment
Ad libitum
What is well-being
State of physiological and psychological harmony of the animal with its internal and external environment
Which vein can be used for IV injection in ferret
Jugular
How would you restrain a rabbit
By grabbing as much skin as possible on the back
You cannot use this method for euthanasia on newborn, nest-living animals. A) cutting the neck B) cervical dislocation C) electric shock D) CO2-inhalation
D) co2-inhalation
Which method would you use to get 10mL of blood from an adult rat
Preparation of abdominal aorta
Which mouse strain is sensitive to pneumocystis carini?
Swiss
Which is not necessary before transport of rodent? A) fasting B) clinical examination C) ear printing D) acclimatisation
A) fasting
When this phenomenon disappears, the narcosis ends with death
Cornea reflex
It is not trie about euthanasia A) it should be cheap B) it should achieve rapid unconsciousness and death C) it should be safe for user D) it should be simple to administer
A) it should be cheap
One is not true about the co-isomeric strains
A) the new gene is the product of natural maturation
B) it can only be maintained in a homozygous form
C) the name contains the strain/sub-strain and the symbol of the mutant gene
D) the co-isogenic strain differs by only one gene from the original one.
B) it can only be maintained in a homozygous form
Dogs is not a good model for A) leptospirosis B) tumour-cancer research C) cardiovascular Artherosclerosis D) epilepsy
C) cardiovascular Artherosclerosis
Mini-pig has a live weight of
20-45 kg
Experimental design cannot be A) cross-over design B) Latin square design C) factorial design D) cross-breeding
D) cross-breeding
The basal circadian rhythm is
Dependent from the gene expression of a protein
Melatonin is produced by the
Pineal gland
This species mostly used in viral respiratory research
Ferret
A chronic stress can cause this type of behaviour
Apathy/aggression
Which environment is good for animals?
Classical music
Which tissue is the least sensitive to suffering
Brain tissue
The naked mole rat has an extra-ordinary long life span because of
Special hyaluronan which prevents cancer
The co-efficient on inbreeding
Means the fraction of the gene that get fixed in a homozygous state
It is inherited disease of some mouse strains
Deafness
Which is a member of Pox viridae
Ectomelia virus
Ringtail is caused by
Too low relative humidity
Not part of refinement of animal experimentation A) hair colour B) health status C) analgesia D) environmental enrichment
A) hair colour
The hearing range of rodents
0,5/1-100/120 kHz
Which species has 1 pair of teats
Guinea pig
Which species has a “peg” (double incisors” teeth
Rabbit
The two important words for animals concerning the pain feeling (Weiss-trail)
Predictability and controllability
Mouse pox is
Caused by ectomelia
It is not a physical euthanasia method A) t61 B) cervical dislocation C) decapitation D) cooling in refrigerator
D) cooling in refrigerator
The African clawed for
Shows mating behaviour after hcg injection
The axolotl is not
A) carnivores
B) capable of regenerating lost limbs completely
C) reaches adulthood after a complete metamorphosis
D) has a long life span (8-10 years)
C) reaches adulthood after a complete metamorphosis
Laboratory animals - except the guinea pig - usually adjust their feeding intake to satisfy their
Energy requirement
Which species can die after oral antibiotic treatment
Rabbit and guinea pig
The role of PPAR is to
Burn fats
One of the following has no anti-cancer effect A) iron B) resveratrol C) CLA D) green tea
A) iron
One of them is an important mechanism of epigenomics
Methylation of the dna
Zebra fish has a life-span of — years
6-8 (internet says 3-5)
One of then has no role in epi-genomics A) DNA-methylation B) change of base in DNA C) sulfurization D) Histon acetylation
B) change of base in DNA
The role of — is a fine regulation of the protein synthesis in the cell
MiRNA/siRNA
In some cases the epi genetic changes may be inherited
If the effect acts during the germ-cell proliferation
You can find neatens at
Axolotl
Pheromones are detected by
VNO
One is true about the ferret
We can prevent the constant oestrus by using GnRH agonist implants
The cephalopods
Are under the protection of the 2010763/EU directive since 2013
Always consider using F1 hybrid because
MCQ: the answer is neither
One of the statements is true
Animals in an outbred stock are anisogenic
A chromorhnydachyrrhea
Vitamin A deficiency
It can go through the uterus wall (2 correct)
Mouse mammary tumour
LCM
Carbohydrates ingestion
Stimulate the fatty acid synthase gene expression
May increase the mitochondria number
Resveratrol
The most used model for drug metabolism study for humans
Macaco
