Exam #6 - FINAL Flashcards
breat self exam
- while laying down use three middle fingers and apply 3 levels of pressure in a circular motion. follow an up and down pattern
- check for changes with hands on hips and chest muscles flexed
- examine under arm while upright with arms slightly raised
- start at age 20
- perform monthly after menses so there is decreased swelling and tenderness
- check the underarm lymph nodes
mastalgia
- breast pain
- most common breast complaint in women, usually benign
- usually conincides with menstrual cycle, decreases with menopause
- noncyclic mastalgia may be due to trauma, arthritic pain, fat necrosis
- wait 7-10 days to see if it goes away. if continuous then look into other things
mastitis
- inflammation that occurs most frequently in lactating women
- s/s; redness, pain, tenderness, fever
- tx: antibiotics, continue breathfeeding (if no draining coming out), if it foesnt improve need to evaluate more closely for inflamm breast cancer, can develop into abscess that requires drainage
- crack in nipple –> staph enters –> infection
- occurs in lots of breatfeeding women
breast lumps
- most are beign, should be followed up
- fibroadenoma: hard, very mobile, teens to 30s, associated with increase in estrogen/progesterone, not cancerous but still check in with doctor
- fibrocystic breast disease: multiple lumps that get bigger with menses, late teens to 40s, increase in size during menstruation, will go away after menopause
- ductal ectasia: hard lumps with nipple discharge and enlarged lymph nodes, near menopause
- intraductal papilloma: bloody nipple discharge, usually no lump, ages 40-55, benign tumors that are soft, clog up milk ducts and increase inflammation and swelling, have to be removed
Fibrocystic changes
- round, well-delineated, mobile lumps that get bigger before menses
- painful, swelling and tenderness
- may have nipple discharge that is milky, green, and yellow
- not genetic
- tx: wait 7-10 days to see if related to menses, breast self exam to watch for changes, cysts can not turn into cancer!, may need aspiration and biopsy to be safe
age-related breast changes
- pendulous breasts
- decreased breast tissue
- increased risk of breast cancer above age 60
- muscles atrophy
- tx: good support bra to decrease back pain, careful palpation of breast tissue, continue with annual mammograms (age 40) and monthly BSEs
- mammograms: if 1st degree relative with cancer then make sure to start getting mammograms 10 years before they were diagnosed
gynecomastia
- enlarged breast tissue in males
- decreaesd testosterone levels
- meds: digoxin, resperdol, steroids, marijuana, cocaine
- tumor on pituitary
- can resolve with tx
breast cancer risk factors
- aging > 60
- long menstrual history (early menarche before age 12 and late menopause after age 50)
- no pregnancies or first pregnancy after age 30
- genetics
- may be affected by obesity, high fat diet, high alcohol usage, long term estrogen replacement (not BC pills)
Breast cancer
- non-cancerous lumps = round, symmetrical, mobile
- s/s: fixed, non-round, pus, inverted nipple, skin dimples, changes in skin color/texture
- DX: mammogram at 40 x 1 yr, earlier if at high risk; ultrasound if suspicious mammogram; ultrasound is suspicious then do biopsy - open surgical biopsy, fine needle aspiration, stereotactic or ultrasound core biopsy
1) BSE
2) MD appt
3) mammogram
4) ultrasound
5) biopsy
fine needle aspiration
- gives definitive diganosis
- local anesthesia
- needle into area and collect cells
- may do a 2nd sample just to confirm negative
- core needle specimen: collects more tissue and is more accurate
stereotactic core biopsy
- prone position, spot for breat to hang
- collects thicker core samples of breast tissue
prognostic testing
- axillary lymph node involvement: most important prognostic factor
- lymph mapping and sentinel lymph node dissection: sentinal node is the node that drains first from the tumor site
- tumor size and shape: larger tumor = poorer prognosis, more well-differentiated the tumor the less aggressive it is
- Estrogen (ER) and progesterone receptor (PR) status: receptor-positive tumors have lower chance of recurrence and are responsive to hormone therapy, tumor positive for estrogen and progesterone is good
- HER-2/neu gene expression: if high, tumor tends to grow fast and is resistance to tx (except herceptin)
sentinal lymph node dissection
- blue dye injected, cut out blue lymph node and channels then sent to determine if cancerous cells in lymph channels as well
- if cancerous, all lymph nodes in axillary will be removed
- can increase lymph edema
lumpectomy
- take out tumor and flesh around it
- if not enough tissue to salvage then lymphectomy wouldnt be done
- remove lump then radiation to breat and tissue area
axillary lymph node dissection
- cancer in lymph nodes
- remove all lymph nodes in that area
- risk for lymph edema
restoring arm fxn after lymphectomy/mastectomy
- immediately post op: HOB 30 degrees, arm up on pillow, support arm when walking, dont walk with hunched back, flex and extend fingers
- 1st day post op: ball squeezes, flex and extend elbow
- later: add exercises
- home care teaching: call if fever/inflamm/redness/back pain/weakness/SOB, no lotions/ointments/deoderant at incision, fit prosthesis 6-8 weeks post op, use barrier birth control if taking chemo or radiation
lymphedema
- post signs: no BP, no IV, no blood draws in that arm - can increase edema
- protect from any trauma (sunburn, pinprick)
- treatment for active lymphedema: elastic bandages, compression sleeves, massage therapy, exercises, elevate above heart level
- can last 5 years post surgery
radiation
- localized site and some surrounding tissue
- done to target basement membrane
- 5 days a week x 5 weeks
- monitor signs of infection
- chemo first and then radiation used
medications
- chemotherapy: affects rapidly dividing cells; side effects = n/v, anorexia, weight loss, weight gain, hair loss, bone marrow supression, fatigue
- hormone therapy: tamoxifen; side effects = hot flashes, mood swings, vaginal dryness, increases risk of blood clots, cataracts, vision problems, stroke, endometrial cancer in postmenopausal women; given to pts with estrogen/progesteron-dependent tumors; mimicks menopause
- biologic/targeted therapy: herceptin; side effects = heart failure, ventricular dysfunction; given to pts with HER-2 gene
- stem cell transplant: increased bone marrow, helps make more new cells
reconstruction options
- immediate, delayed-immediate or delayed
- saline or gel implant
- tissue expanders used
- flap (autologous): wont restore sensation
- will take 3-6 months to see true change in appearance
- must continue BSE
- must have annual mammograms
breast implants and tissue expanders
- tucked under pectoral muscles
- cancer can still develop in pectoral basement
- expander can either expand or work as actual implant
- easy recovery, few weeks
- increased risk of complicaitons so women should massage and move around implant to prevent fibrin buil-up
breast flap procedures
- TRAN, Trans abdominal cutaneous flap
- abd muscle used to create a breast mound
- doctor does a tummy tuck
- weeks to months to recover
- more natrual
- less long term complications
breast augmentations
- cosmetically create a nipple
- tattoo nipple
- breat implant under breast tissue or muscle
breast reduction
- cut around nipple, remove fat and tissue
- helps with back pain
STIs
- more susceptible if female, young, already have another STI
- ## can transmit STI even if no s/s
STI tx
- oral, IM or IV abs; creams will not work
- viral STDs are not curable (herpes, HPV)
- s/s recur because they are re-infected
- must tx all sexual partners for past 30-60 days
- no sex for 7 days even with condom, wait for meds to work, skin integrity
STI prevention
- abstinence is best but latex condom is next best
- oral contraceptives increase risk of STDs
- spermididal jellies and creams do not prevent STDs
STI assessment
- recent (last 30-60 days) sexual contacts - most important thing to ask
- type of birth control used
- condom use
- history of STDs
- use of IV drugs
- sexual activities
- oral BC can change PH of vagina
STI teaching
- take all abx as directed
- return for follow up and re-culture
- no douching, clean genitals and urinate after sex: can increase risk of pelvic inflamm disease
STI info
- gonorrhea, syphlis, and often chlamydia are reportable diseases
- screening programs are targeted towards women because of vaginal environment, asymptomatic or longer for s/s to show up
STI transmission
- usualyl through sexual activity
- gonorrhea and chlamydia are hand in hand, always give abx for both if a person has one
- syphilis: open lesions are highly contageous
- herpes: skin to skin contact even if no visible lesions
STI s/s
- often asymptomatic, especially for women
- throat, mouth, eyes, anus can also become infected
lab tests for STIs
- urine/discharge cultures, DNA and antigen tests
- gonorrhea: smears, gram stains are not helpful for diagnosis in women (women’s natural flora can give false positives)
- HPV: no way to test men, only way to tell is if they get worts
- syphilis: VDRL or RPR (rapid plasma recongent test) is screening test, must folow with FTA-Abs (fluoresant treponema antibody absorption test) or TPPA (T palidum partico agglutination test) to diagnose
- if VDRL or RPR come back positive then must follow up with FTA-Abs/TPPA test to make sure it is not a false positive
STI Tx
- gonorrhea or chlamydia: 2 drugs for gonorrhea or chlamydia because we are going to treat both: ceftriaxone, cefixine, boxycyclizine or azithromycin
- HPV: cryotherapy, heat, chemicals, laser to remove; gardisil vaccine to prevent strains 16 & 18 (commonly linked to cancer or cervical and penile), can be given to age 9-26, preferably before sexual activity, 3 IM shots over 6 month period
- herpes: oral acyclovir, can also use as suppression therapy; condoms even if no lesions, no sex if lesions are present, Famcycloviere, Acyclovere, Bancyclovere FAV tx; if HSV2 and 6+ outbreaks then need to be put on FAV
- syphilis: penicillin G (IM) or doxycycline PO; wear gloves if pt has lesions!
STI Cure
- yes: gonorrhea, chlamydia, syphilis. bacterial with abx, can cause systemic issues, pelvic inflamm disease
- no: HPV, herpes, HIV. viral, no cure, always a carrier
- gonorrhea has some resistant strains, take full course of meds
- most common cause of reoccurance is REINFECTION (NOT a tx failure)
STI complications
- infertility (except for HPV and herpes), Pelvic inflamm disease, ectopic pregnancy, more STIs, HIV infection
- HPV: cervical, penile, ovarian cancers
- Hepres: keratitis, metastatic lesions, AIDS
- syphilis: eyes, heart, brain, bone, skin damage, deat, shut down organs, blindness, aortic anyeurisym, neurosponalis, limp/gait issues
STI risks to fetus, newborns
- miscarriage, premature birth, eye infections, blindness (can give eye drops prophylaxis for gonorrhea)
- HPV: can block birth canal, resp disease
- herpes: can be fatal to neonate
- syphilis: stillbirth, birth defects
benign prostatic hypertrophy (BPH)
- occurs in 50% of men > 50, 90% men > 80
- doesn’t increase risk of prostate cancer
- causes: buildup of tissue in inner part of urethra, endorcrine changes associated with aging
- patho: develops in inner part of prostate, enlargement compresses the urethra
- risk factors: obesity, physical activity, alcohol, smoking, diabetes, family history of BPH, aging
- decrease in testosterone –> increase in estrogen –> increased cell growth and deoxyhydrotestosterone
- hypertrophy: size of enlargement is not as significant as lcoation
BPH s/s and complications
- s/s: gradual onset, worsen as obstruction increases, symmetrically enlarged, firm, smooth prostate
- obstructive: decrease in force of stream, difficulty starting stream, intermittency in stream, dribbling
- irritative: frequency, urgency, painful urination, bladder pain, nocturia, incontinence
- cx: fairly uncommon, but could cause urinary incontinence, UTI that could lead to sepsis, bladder stones (alkalitive urine), renal failure from hydronephrosis (post renal failure), pyelonephrosis, bladder drainage
BPH diagnosis-
- history and physical exam: look for enlarged, firm, smooth prostate
- digital rectal exam
- american urinary association survey for BPH
- UA with culture to r/o infection
- PSA to r/o cancer, normal 0-4
- serum creatinine to r/o renal issues
- transrectral ultrasound (TRUS) with biopsy to r/o cancer
- uroflowmetry to see the extent of blockage
- postvoid residual urine volume to see degree of obstruction
- cycstoscopy, go up urethra to see if excess tissue
BPH treatment
- based on how much the symptoms are bothering the patient or presence of complications, NOT based on size of prostate
- watchful waiting if mild symptoms: diet changes (decrease caffeine and artificial sweetners, limit spicy/acidic foods), avoid decongestants and anticholinergics (increases constriction), restrict evening fluid intake, drink lots during the day, timed voiding schedule with slightest urge to go to the bathroom