Exam 4 Tables and Factoids

Question 1

What were the findings of the ETDRS study? (3)

Answer 1

1. Scatter photocoagulation was not indicated for mild/moderate NPDR but may be helpful for high risk
2. Focal photocoagulation was beneficial. It increased the possibility of VA increase, reduced risk of vision loss
3. Focal photocoagulation should be considered for patients with CSME

Question 2

What were the findings of the DRS?

Answer 2

A high benefit to risk ratio for using photocoagulation for diabetic retinopathy

1. Reduced risk of significant vision loss
2. Maintained typically one line of VA

Question 3

What were the findings of the DRVS?

Answer 3

Early vitrectomy is beneficial for T1 patients

Question 4

What were the findings of the DCCT? (3)

Answer 4

Intensive insulin therapy reduced clinically meaningful DR by 35-74%

Intensive insulin therapy reduced the risk of severe NPDR and PDR by 45%

Intensive insulin therapy reduced the development of DR by 27%

Question 5

What were the findings of the RISE and RIDE trials?

Answer 5

Lucentis efficacy on DME

Lucentis had an improvement on the diabetic retinopathy severity scale compared to control

Question 6

What were the findings of the VIVID and VISTA trials?

Answer 6

Compared Eylea to Laser treatment for DME

Eylea > Laser in both efficacy and safety

Question 7

What were the findings of the BOLT study?

Answer 7

Avastin vs Laser treatment for DME
Avastin > Laser
Small scale study though, not statistically significant

Question 8

Define Clinically Significant Macular Edema WORD FOR WORD from the notes.

Answer 8

One or more zones of retinal thickening larger than one disc diameter in size, located within one disc diameter from the center of the macula or zones of retinal thickening at or within 500um from the center of the macula or hard exudate associated with retinal thickening at or within 500um from the center of the macula