Exam 4 Restrictive Lung Disease Flashcards
What is restrictive lung disease?
- Decreased lung compliance and lung expansion
- Inability to increase lung volume in proportion to an increase in alveoli pressure
- Reduction in surface area for gas diffusion
- All lung volumes are decreased
- Preservation of expiratory flow rates
__________ will result from the inability to clear lung secretions, and hypoventilation
- Hypoxia
Restrictive Lung Disease Dx
* Mild:
* Moderate:
* Severe
Dr. E pretty much told us this will be a test question.
- Mild - TLC 65%–80% of the predicted value
- Moderate- TLC 50%–65% of the predicted value
- Severe - TLC < 50% of the predicted value
Acute Pulmonary Edema is caused by
- Increased capillary pressure OR
- Increased capillary permeability
What will you see on a CXR for someone with acute pulmonary edema?
- Bilateral symmetrical perihilar opacities on CXR
- Butterfly appearance d/t increased capillary pressure
Cardiogenic pulmonary edema signs and symptoms
- Dyspnea
- Tachypnea
- SNS activation
What valvular disorder can cause cardiogenic pulmonary edema?
- Acute aortic regurgitation
- Mitral regurgitation
- Mitral valve stenosis
- Left ventricular outflow tract. obstruction
- Renovascular HTN (renal artery stenosis)
What is the are possible results of aspiration of gastric fluids?
- Destruction of surfactant-producing cells
- Damages pulmonary capillary endothelium
- Atelectasis and leakage of intravascular fluid
- Capillary permeability pulmonary edema
What do patients present with during aspiration?
What will the CXR show with aspiration?
- Arterial hypoxemia
- Tachypnea
- Bronchospasm
- Acute pulmonary HTN
- CXR will show aspiration pneumonitis usually in the superior segment of the RLL (right bronchi is a straight shot)
Aspiration Treatment
- Supplemental oxygen and PEEP
- Bronchodilation
- Antibiotics (controversial- hit or miss)
- Steroids (controversial- hit or miss)
Pulmonary EdemaAnesthesia Considerations
- Optimize patient before Elective surgery
- Make sure large pleural effusions are drained
- Persistent hypoxemia biggest problem consider post op ventilation and PEEP
- Post-op vent management
What is Acute Respiratory Failure
- Inability to provide adequate arterial oxygenation and/or elimination of CO2
With ARF, PaO2< _______ mm Hg despite oxygen supplementation and in the absence of a right-to-left intracardiac shunt.
- < 60 mmHg
PaCO2 during Acute Respiratory Failure
PaCO2can increased, unchanged, or decreased
A PaCO2 above 50 mm Hg in the absence of respiratory compensation for __________is consistent with the diagnosis of acute respiratory failure.
- metabolic alkalosis
Acute RF will result in:
_________ PaCO2
_________ Arterial pH
- ↑ PaCO2
- ↓ Arterial pH
Chronic RF
_______ pH
What organ will compensate for Chronic Renal Failure?
- Arterial pH between 7.35 and 7.45, despite an increased PaCO2
- Renal compensation: ↑ HCO3-
Acute Respiratory Failure
________ FRC and lung compliance
________ PVR and pulmonary HTN
- Decreased FRC and lung compliance
- Increased PVR and pulmonary HTN
Acute Respiratory Failure Treatment
- Establish patent and open upper airway
- Correction of hypoxemia
- Removal of excess CO2
Acute Respiratory Distress Syndrome (ARDS)
- Inflammatory injury to the lung manifested an acute hypoxemic respiratory failure
Acute Respiratory Distress Syndrome (ARDS) Causes
- Direct or indirect lung injury causes
- Sepsis
Acute Respiratory Distress Syndrome (ARDS) Signs/Sx
ARDS Chest CXR is indistinguishable from what condition?
- Rapid-onset respiratory failure
- Refractory arterial hypoxemia
- CXR - indistinguishable from cardiogenic pulmonary edema
Proinflammatory cytokines released in ARDS will lead to capillary membrane permeability in alveoli.
What are direct and indirect lung injuries for ARDS?
What is the biggest indirect lung injury?
- Sepsis is the biggest indirect injury for ARDS
Classification (PaO2/FIO2ratio) for ARDS
Mild-
Moderate -
Severe-
Mild- 201 mm Hg - 300 mm Hg
Moderate - 101 mm Hg - 200 mm Hg
Severe- ≤ 100 mm Hg
To diagnose ARD, what needs to be present in the patient’s CXR?
- Bilateral findings in at least 3 lung quadrants not explained by pleural effusion or atelectasis
What does an ECHO rule out for ARDS?
R/O cardiogenic cause of pulmonary edema
An ECHO is used bc a CXR can distinguish between ARDS and Cardiogenic Pulmonary Edema.
What causes pulmonary HTN?
- Pulmonary artery vasoconstriction and pulmonary capillary bed destruction
- Acute right-sided HF
ARDS Treatment
Prone positioning
* Lung recruitment
* Improves ventilation/perfusion matching
ECMO
* Severe hypoxemic
* Hypercapnic respiratory failure
Conservative fluid therapy
Neuromuscular blockers
* Less barotrauma
* Less secretion of both pulmonary and systemic proinflammatory mediators
What is Sarcoidosis
Systemic granulomatous disorder primarily involving intrathoracic lymph nodes and the lungs
What are the different types of sarcoidosis
- Ocular sarcoidosis - uveitis (eye redness)
- Myocardial sarcoidosis - conduction defects and dysrhythmias
- Endobronchial sarcoid- c/o chest tightness
- Laryngeal sarcoidosis - occurs in 5% of pts
Sarcoidosis signs, symptoms, and manifestations?
- No symptoms at the time of presentation
- CXR - abnormal findings
- Wheezing, dyspnea, and cough
- Cor pulmonale
- Hypercalcemia (classic manifestation) ↑Ca2+
- Increase ACE activity
How is Sarcoidosis diagnosed?
Mediastinoscopy
ACE activity is ____________ with sarcoidosis
increased