Exam 4 Pharma

Question 1

UTI Abx - Floroquinolone

Answer 1

Uncomplicated UTI: Rhabdo, Rash, GI, C diff, seizures . 1 hr pre or 2 hr post meal

Question 2

UTI Abx - Nitrofurantoin

Answer 2

Not for GFR < 50

Periph neuropathy

Question 3

UTI Abx- Amoxicillin

Answer 3

Allergy

Highly resistant

Question 4

UTI Analgesic - Phenazopyridine

Answer 4

Dark orange urine

Question 5

Pyelonephritis Abx

Answer 5

TMP-SMX
Ciprofloxacin
gentamicin
3rd generation cephalosporin
Oral or IV

Question 6

Pyelonephritis NSAID

Answer 6

For fever and discomfort

Question 7

BPH 5-alpha Reductase inhbitors

Answer 7

Finasteride, dutasteride
Interfere w/ testosterone to DHT conversion, shrink
Se: low libido and ejaculate, ED

Question 8

BPH - Alpha Blockers

Answer 8

doxazosin, terazosin, tamsulosin

Relax smooth muscle, NOT shrink, helps w/ sx
Se: Ortho hypo, dizzy, retrograde ejac, nasal cong

Question 9

BPH Herbals

Answer 9

Saw Palmetto
Relief, stops conversion
Se: GI, bleeding (stop before surgery)
Better tolerated and as effective

Question 10

Gout - Anti inflammatories

Answer 10

colcichine - it Interferes with the functions of the WBCs in initiating and perpetuating inflammatory response
SE: GI Upset, diarrhea, NV, abd pain, aplastic anemia
Take w/ meals NOT with grapefruit juice

Question 11

Gout NSAIDS

Answer 11

indomethacin

Ibuprofen

Question 12

Gout Uricosuric

Answer 12

Probenecid - inhibits renal absorption of urates and increases excretion, decreases serum uric acid
SE: kidney stones, GI upset, aplastic anemia, flusing. Action decreased by salicylates

Question 13

Gout combo drug

Answer 13

Colbenemid - colchicine + probenecid

Question 14

Gout Xanthine Oxidase Inhibitors

Answer 14

febustat - interrupts purine breakdown

Allopurinol - Prevents uric acid in blood by blocking formation
Se: Increases action of antidiabetic agents, hypotension, hepatitis, bone marrow depression, NV flusing, rash, increases theopyhlline toxicity

Question 15

Gout ARB

Answer 15

Losarten- good for elderly with HTN and gout, promotes excretion

Question 16

Gout others

Answer 16

ASA and Thiazide diuretics- block renal excretion of uric acid

Question 17

OA Pharma

Answer 17

Acetominophen max dose 2600 /day
Topical creams - capsaicin, methyl salicate
NSAIDS - misoprostol w/ GI complications

Question 18

OA Viscosupplementation

Answer 18

hyaluronic acid injection

Question 19

OA COX 2 Inihbitors

Answer 19

celecoxib SE: CV disease and GI distress

Question 20

RA DMARDS

Answer 20

methotrexate- drug of choice, rapid anti inflammatory
SE: myelosuppression, aplastic anemia and GI toxicity, teratogenic
Sulfasalazine
Leflunomide

Question 21

RA Biologics:

Answer 21

Serious Infection risk, no live vaccines
etanercept, adalimumab, infliximab: injectable
SE: bacterial sepsis, invasive fungal infection and TB
Mantoux before tx recommend

Question 22

RA Antimalarial

Answer 22

Hydroxychloroquine
Antiinflammatory works w/ methotrexate
SE: BM Suppression, GI ulcers, infection risk, rashes, alopecia, bladder toxicity

Question 23

RA Sx Treatment

Answer 23

NSAIDs
Glucocorticoids
Antibiotics
Gold Salts
Antidepressants
Sleep aids

Question 24

SLE Pharma

Answer 24

Immunosuppressant - imuran, cyclophosphamide, steroids
NSAIDS
DMARDS
Antimalarial
Anticonvulsants

Question 25

OP Biphosphonates

Answer 25

alendronate, risendronate, ibandronate, zoledronic acid SE: GI, ulcers, jaw necrosis

Question 26

OP Selective Estrogen Receptor Modulator SERMs

Answer 26

Raloxifene | SE: Increased risk thromboembolism, allergy, chest tightness

Question 27

OP Calcitonin

Answer 27

Nasal application | Se: Nasal irritation, flushing, GI, urinary frequency

Question 28

MS Interferons

Answer 28

beta 1a | Beta 1b

Question 29

MS Synthetic Immunomodulator

Answer 29

glatiramer acetate

Question 30

MS Steroids

Answer 30

prednisone, methylprednisone

Question 31

MS Antispasmodics

Answer 31

baclofen

Question 32

Parkinsons Dopaminergics

Answer 32

Carbidopa/Levadopa - unpredictable, wears on and off, paradoxical intoxication

Question 33

Parkinsons Dopamine agonists

Answer 33

bromocriptine

Question 34

Parkinsons Catechol O methyltransferase COMT inhibitors

Answer 34

entacapone

Question 35

Parkinsons MAO-B inhibitors

Answer 35

rasagiline

Question 36

Parkinsons Anticholinergics

Answer 36

benztropine

Question 37

MG Anticholinesterase inhibitors

Answer 37

pyridostigmine bromide

Question 38

MG Corticosteroids

Answer 38

prednisone

Question 39

MG Tensilon

Answer 39

edrophonium

Question 40

Spastic Bladder Anticholinergic

Answer 40

propantheline | oxybutynin

Question 41

Spastic BLadder Skeletal muscle relaxants

Answer 41

baclofen

Question 42

Flaccid Bladder Cholinergic

Answer 42

bethanechol

Question 43

Constipation - bulk forming laxatives

Answer 43

polyethylene glycol | Psyllium

Question 44

Constipation - Stool softener

Answer 44

docusate sodium

Question 45

Diarrhea - antidiarrheal

Answer 45

loperamide | diphenoxylate w/ atropine

Question 46

Diarrhea - anticholinergic

Answer 46

propantheline

Question 47

IBD Aminosalycates

Answer 47

sulfasalazine mesalamine Decrease mild/mod inflammation and MAINTAIN REMISSION SE: orange urine, photosensitivity (sulfasalazine), decreased urine output, flu like sx

Question 48

IBD Abx and CS

Answer 48

``` DONT MAINTAIN REMISSION metronidazole (tx secondary infections) CS: Prednisone PO Hydrocortisone IV budesonide PR ```

Question 49

IBD Immunosuppressant

Answer 49

6-mercaptopurine azathioprine methotraxate MAINTIAIN REMISSION

Question 50

IBD Biologic

Answer 50

natizumab infliximab MAINTAIN REMISSION

Question 51

Lower GI Saline agent

Answer 51

magnesium hydroxide

Question 52

Lower GI stimulant

Answer 52

bisacodyl

Question 53

Lower GI Vit B12

Answer 53

cobalamin

Question 54

Lower GI chloride channel activator

Answer 54

lubiprostone