Exam 4 - Bowel Elim Drugs

Question 1

Types of Drugs used to treat peptic ulcer disease

Answer 1

H-2 Receptor Antagonists
Antacids
Proton Pump Inhibitors
Antipeptic agents
Prostaglandins

Question 2

Types of drugs used as antidiarrheals

Answer 2

Bismuth Subsalicylate
Loperamide
Opium Derivitives

Question 3

Types of drugs used as laxatives

Answer 3

Chemical Stimulants
Bulk Stimulants
Lubricants

Question 4

Action of H-2 (Histamine-2) Receptor Antagonists

Answer 4

Prevents release of HCL in response to gastrin

Question 5

Action of Antacids

Answer 5

neutralize acids at a chemical level.

Question 6

Action of proton pump inhibitors

Answer 6

inhibit secretion of HCL into stomach

Question 7

Action of Antipeptic agents

Answer 7

coats injured tissue to prevent further acid damage

Question 8

Action of prostaglandins

Answer 8

inhibit gastrin secretion and increase mucus secretions in stomach forming a buffer

Question 9

Action of chemical stimulant laxatives

Answer 9

Direct chemical stimulation of GI tract

Question 10

Action of bulk stimulants

Answer 10

Increases bulk or fluid volume in lumen, stimulating peristalsis

Question 11

Action of Bismuth Subsalicylate

Answer 11

Coats GI tract lining. Reduces tract irritation which would otherwise stimulate tract motility.

Question 12

Action of Loperamide (imodium)

Answer 12

Direct effect on tract muscles. Slows peristalsis, increases absorption.

Question 13

Action of Opium Derivatives (paregoric)

Answer 13

Causes GI spasms, stopping peristalsis and diarrhea.

Question 14

Action of gastrointestinal stimulants (metoclopramide (Reglan))

Answer 14

Blocks dopamine receptors, increases colon sensitivity to acetylcholine. Increases motility.

Question 15

Chemical name for TUMS

Answer 15

calcium carbonate

Question 16

Brand name for Sodium Bicarbonate

Answer 16

Bell-ans

Question 17

At what step of acid production do proton pump inhibitors disrupt the process.

Answer 17

Final step (secretory receptors on luminal surface).

Question 18

Indications for proton pump inhibitors

Answer 18

Short Term: Active duodenal ulcers, GERD, Erosive esophagitis, benign active gastric disease.
Long Term: Pathological hypersecretory conditions

Question 19

Adverse effects of proton pump inhibitors

Answer 19

Abdominal pain, diarrhea, tongue atrophy, rash, alopecia, pruritis.

Question 20

Indications of antipeptic agents

Answer 20

to promote ulcer healing

Question 21

What is an antiemetic?

Answer 21

medication used to prevent/treat nausea and vomiting.

Question 22

What do phenothiazines and other drugs of its class do?

Answer 22

Suppress multiple areas of CNS

Question 23

Functions of Metoclopramide

Answer 23

GI stimulator, as well as antiemetic used for chemotherapy

Question 24

What is the CTZ

Answer 24

Chemoreceptor trigger zone

Question 25

Action of 5-HT3 receptor blockers

Answer 25

Block nausea and vomiting receptors in the CTZ.

Question 26

Adverse effects of 5-HT3 receptor blockers

Answer 26

Urinary retention, constipation, headaches, drowsiness

Question 27

Action of Substance P/Neurokinin 1 Receptor Antagonists.

Answer 27

act directly in CNS to prevent nausea and vomiting.