Exam 4 (11)

Question 1

Leukocyte Extravasation (4 steps)

Answer 1

1. Chemoattractants promotes display of P-selectin cell adhesion molecules
2. Leukocytes uses inherent carbohydrate membrane selectin ligand to slow their movement (rolling)
3. Inside-out mechanism from (2) activates leukocyte membrane integrins –> binds to CAMs
4. Leukocyte undergoes dramatic shape change to migrate in btwn endothelial cells