Exam 3 - Thrombosis

Question 1

VTE treatment - UFH regular IV dosing

Answer 1

80 U/kg IV bolus followed by 18 U/kg/hr iV infusion

Question 2

VTE treatment - UFH regular subQ dosing

Answer 2

initial dose of 333 U/kg subQ, followed by 250 U/kg subQ q12hrs

Question 3

UFH renal adjustments

Answer 3

None

Question 4

Is monitoring required for both IV and subQ UFH treatment?

Answer 4

No, only required for IV treatment

Question 5

monitoring parameters for UFH IV treatment

Answer 5

aPTT 6 hrs after bolus and each dose adjustment OR anti-Xa activity for pts with excess factor VII or large doses

Question 6

target range for aPTT

Answer 6

1.5-2.5x the normal value

Question 7

VTE treatment - enoxaparin regular dosing

Answer 7

1 mg/kg subQ q12hrs OR 1.5 mg/kg subQ q24hrs

Question 8

VTE treatment -

enoxaparin renal adjustments

Answer 8

For CrCl < 30 mL/min, 1 mg/kg q24hrs subQ

Question 9

monitoring parameters for enoxaparin

Answer 9

anti-Xa activity for pregnant pts, burn pts, severe renal impairment, pts with extreme weights (< 50 kg/> 190 kg), prolonged therapy

Question 10

VTE treatment - dalteparin regular dosing

Answer 10

100 U/kg subQ q12hrs OR 200 U/kg subQ q24hrs

Question 11

dalteparin renal adjustments

Answer 11

None

Question 12

What is the regular dosing for fondaparinux in VTE treatment?

Answer 12

< 50 kg = 5 mg subQ q24hrs
50-100 kg = 7.5 mg subQ q24hrs
> 100 kg = 10 mg subQ q24hrs

Question 13

What renal adjustments are required with fondaparinux treatment?

Answer 13

CI for CrCl < 30 mL/min

Question 14

What monitoring parameter are required for fondaparinux treatment?

Answer 14

anti-Xa activity

Question 15

What is the regular dosing for apixaban in VTE treatment?

Answer 15

10 mg PO q12hrs for 7 days, followed by 5 mg PO q12hrs

Question 16

What are the renal adjustments required with apixaban treatment?

Answer 16

CI for CrCl < 25 mL/min

Question 17

What is the regular dosing for rivaroxaban in VTE treatment?

Answer 17

15 mg PO q12hrs for 21 days, followed by 20 mg PO q24hrs

Question 18

What are the renal adjustments required with rivaroxaban treatment?

Answer 18

CI for CrCl < 30 mL/min

Question 19

What is the regular dosing for edoxaban in VTE treatment?

Answer 19

60 mg PO daily OR 30 mg PO daily for pts less than or equal to 60 kg

Question 20

What are the renal adjustments required with edoxaban treatment?

Answer 20

CI for CrCl < 15 mL/min

Question 21

What is the regular dosing for dabigatran in VTE treatment?

Answer 21

150 mg PO q12hrs

Question 22

What are the renal adjustments required with dabigatran treatment?

Answer 22

CI for CrCl < 30 mL/min

Question 23

What are the oral therapies that cannot be started right away and the parameters needed prior to administration?

Answer 23

edoxaban and dabigatran cannot administered until 5-10 days of parental anticoagulation therapy is received

Question 24

What is the brand name of enoxaparin?

Answer 24

Lovenox

Question 25

What is the brand name of dalteparin?

Answer 25

Fragmin

Question 26

What is the brand name of fondaparinux?

Answer 26

Arixtra

Question 27

What is the brand name of apixaban?

Answer 27

Eliquis

Question 28

What is the brand name of rivaroxaban?

Answer 28

Xarelto

Question 29

What is the brand name of edoxaban?

Answer 29

Savaysa

Question 30

What is the brand name of betrixaban?

Answer 30

Bevyxxa

Question 31

What is the brand name of dabigatran?

Answer 31

Pradaxa