Exam 3 Second Set of Lecture Slides Practice Questions

Question 1

(T or F) Bioavailability is the fraction of an administered dose that reaches the systemic circulation intact.

Answer 1

True

Question 2

(T or F) dosage forms are designed to convey performance by balancing the composition of the excipients, the drug’s physicochemical properties and to overcome the physiological barriers required for a safe and efficacious response.

Answer 2

True

Question 3

(T or F) When blinding clinical trials, it is often important to mask the organoleptic properties of the comparator and the drug being tested. These senses include sight, smell, taste, touch, and sound.

Answer 3

True

Question 4

(T or F) The stomach has a significantly increased surface area due to villi, folds of Keckring and microvilli.

Answer 4

False → the small intestine

Question 5

Which is NOT included in the acronym of ADMET?

Answer 5

a) excretion
b) toxicity
c) metabolism
d) dissolution ←
e) distribution

Question 6

(T or F) The microenvironmental pH at the membrane surface may be different than the lumen based on the fact that the mucus and the glycocalyx have buffering effects.

Answer 6

True

Question 7

(T or F) Drug levels observed in the therapeutic window can be governed in part by transporters and metabolism, based on the compound being studied. Therefore, transporters and enzymes do not play an important role in drug product performance.

Answer 7

False

Question 8

All of the following can reduce the bioavailability of an orally administered drug EXCEPT:

Answer 8

a) poor dissolution in the GI tract
b) poor penetration of the blood brain barrier ←
c) chemical degradation in the GI tract
d) poor solubility in the GI fluids
e) poor absorption across the GI mucosa