Exam 3 Review Questions Flashcards
Which of the following statements is true?
The liver has a low blood flow and a high vascular resistance
The liver has a low blood flow and a low vascular resistance
The liver has a high blood flow and high vascular resistance
The liver has a high blood flow and a low vascular resistance
The liver has a high blood flow and a low vascular resistance
Which of the following would not be a function of the liver?
Gluconeogenesis
Formation of Urea
Synthesis of Prothrombin
Synthesis of Calbindin
Synthesis of Calbindin
Which of the following is not characteristic of the metabolic syndrome associated with diabetes?
Peripheral Neuropathy
Obesity
Fasting Hyperglycemia
Hypertension
Peripheral Neuropathy
Heme is released from damaged RBCs and split into globin and heme by macrophages. Heme is then converted into which of the following by heme oxygenase?
Cholic Acid
Biliverdin
Bilirubin
Urobilinogen
Biliverdin
A higher than normal back pressure in hepatic veins may lead to the following conditions.
Jaundice
Cirrhosis
Ascites
Diabetes
Ascites
Which of the following best represents the most important function of insulin in the body?
Activates phosphorylase and phosphatase necessary for the uptake of glucose by the liver
Controls from moment to moment whether fat or carbohydrate will be used by cells for energy
Activates lipoprotein lipase to split triglycerides into fatty acids
Activates the ornithine transport mechanism
Controls from moment to moment whether fat or carbohydrate will be used by cells for energy
In the pituitary gland, somatotropes (acidophils) secrete which of the following trophic hormones?
Thyroid Stimulating Hormone
Human Growth Factor
Adrenocorticotropic Hormone
Luteinizing Hormone
Human Growth Factor
The hormone response element is best characterized by which of the following?
An intracellular protein that binds to a lipid soluble hormone to form the hormone-receptor complex
A regulatory sequence of DNA
Phosphatidylinositol bisphosphate component of a second-messenger system
A tyrosine-binding protein for thyroxine
A regulatory sequence of DNA
Some signal transduction mechanisms involve calcium. In these pathways a change in membrane potential opens calcium channels. Calcium ions enter the cell and bind to which of the following?
Janus Kinase
The receptor component of a G protein
Calmodulin
Diacylglycerol
Calmodulin
Down regulation of receptors may occur as a result of which of the following:
Inactivation of some of the intracellular protein signaling molecules
Activation of some of the receptor molecules
Increased production of receptors
Increase in the target cell’s responsiveness to the hormone
Inactivation of some of the intracellular protein signaling molecules
One of the best known stimuli for increasing the rate of thyroid releasing hormone secretion is…?
Cold
Anxiety
cAMP
Excitement
Cold
Which of the following is a common cause of hyperthyroidism?
Hashimoto Disease
Grave’s Disease
Endemic Goiter
Cretinism
Grave’s Disease
The basal membranes of thyroid cells contain symporters for iodide. What ion is co-transported with iodine by these symporters?
Sodium
Potassium
Chloride
Hydrogen
Sodium
The major hormonal product of the thyroid gland is thyroxine. How many iodinated tyrosine residues are found in thyroxine?
One
Two
Three
Four
Four
Pendrin is used for which of the following functions?
As a sodium-iodide symporter in the basal membrane of a thyroid follicle cell
As a hepatic-derived conjugating protein for the transport of thyroxine in the blood
As a chloride-iodide counter-transport in the apical membrane of a thyroid follicle cell
As a decoupling protein used to separate iodide from thyroglobulin during the recycling of thyroxine
As a chloride-iodide counter-transport in the apical membrane of a thyroid follicle cell
Osteoclasts do not have receptors for parathyroid hormone; instead they respond to secondary signals from osteocytes which do have the receptors. Which of the following is important as a major secondary signal ligand in this communication process?
Osteoprotegerin
Pendrin
Calmodulin
Calbindin
Osteoprotegrin
Hyperkalemia, mild acidosis, rise in RBC concentration, loss of ability to maintain normal blood glucose concentrations between meals, and changes in pigmentation pattern are all consistent with which of the following conditions? (Don’t assume exact same question will appear on test, think about variation could we have on the test) (Use as examples of what you will see on the test, but not word for word)
Cushing’s
Hypothyroidism
Addison’s
Hyperparathyroidism
Addison’s
Which of the following is/are functions of glucocorticoids? (Think about which is not a function)
Stimulation of gluconeogenesis Decreased glucose utilization by cells Resists inflammation Resists stress All the above are functions of glucocorticoids
All the above are functions of glucocorticoids
Aldosterone is the major mineralocorticoid and is secreted by which of the following regions of the adrenal cortex?
Zona Glomerulosa
Zona Fasciculata
Zona Reticularis
Zona Medullaris
Zona Glomerulosa
Cortisol secretion is controlled mainly by which of the following factors?
Plasma potassium concentration
Angiotensinogen II
Plasma sodium concentration
ACTH
ACTH
Which of the following resists stress, resists inflammation and stimulates gluconeogenesis but may lead to “adrenal diabetes?”
Aldosterone
Cortisol
Angiotensin II
Pregnenolone
Cortisol
Which of the following is not a characteristic of lack of aldosterone?
Reduction in blood volume
Hypernatremia
Hyperkalemia
Reduction in blood pressure
Hypernatremia
“Adrenal Diabetes” may occur due to excess of which of the following?
Aldosterone
Mineralocorticoids
Glucocorticoids
Androgenic Hormones
Glucocorticoids
Addison’s Disease is due to a deficiency of which of the following?
Glucocorticoids
Mineralocorticoids
Androgenic Hormones
Both A and B
Glucocorticoids
Mineralocorticoids
Which of the following characteristics of Addison’s Disease is due to a glucocorticoid deficiency?
Muscle Weakness
Decrease in cardiac output
Rise in RBC concentration
Mild Acidosis
Muscle Weakness
The major glucocorticoid secreted by the adrenal cortex is…?
Aldosterone
Estrogen
Cortisol
DHEA
Cortisol
Spironolactone blocks mineralocorticoid receptors. This would probably have which of the following effects?
Hypernatremia
Increase in extracellular fluid volume
Reduction in cardiac output
Anemia
Reduction in cardiac output
Moon face, “buffalo torso,” hypertension and increased blood glucose are characteristics of which of the following?
Addison’s Disease
Cushing’s Disease
Cretinism
Grave’s Disease
Cushing’s Disease
The active form of Vitamin D promotes the intestinal uptake of calcium by increasing the formation of which of the following substances?
Apoprotein B
Calbindin
Albumin
Calciferol
Calbindin
Hypocalcemia usually becomes lethal at which of the following levels?
12 mg/dl
9.5 mg/dl
6 mg/dl
4 mg/dl
4 mg/dl
Normally the body takes in about 1000 mg of calcium per day orally. How much of this is lost in the feces per day?
350 mg
750 mg
900 mg
990 mg
900 mg
Parathyroid Hormone has which of the following effects on renal tubules?
PTH promotes the reabsorption of potassium
PTH promotes the reabsorption of calcium
PTH promotes the reabsorption of sodium
PTH promotes the reabsorption of potassium, calcium and sodium
PTH promotes the reabsorption of calcium
The conversion of 25-hydroxycholecalciferol to 1,25-hydroxycholecalciferol in which of the following?
Bone
Liver
Blood
Kidney
Kidney
Death due to hypoparathyroidism is often due to which of the following effects?
Massive losses of calcium from the skeletal system
Excessive reabsorption of sodium followed by tetany
Laryngeal muscle spasms
Vitamin D Deficiency
Laryngeal muscle spasms
Approximately 40% of plasma calcium is bound to plasma proteins and is not filtered by the kidneys. What effect does acidosis have on plasma calcium ion concentration (unbound)?
There is an increase in bound calcium and the calcium ion concentration increases
There is a decrease in bound calcium and the calcium ion concentration decreases
There is a decrease in bound calcium and the calcium ion concentration increases
There is an increase in bound calcium and the calcium ion concentration decreases
There is a decrease in bound calcium and the calcium ion concentration increases
Which of the following nerves supplies parasympathetic innervation to the parotid gland?
Facial Nerve
Trigeminal Nerve
Glossopharyngeal Nerve
Vagus Nerve
Glossopharyngeal Nerve
Which of the following conditions describes the effects of the ANS on sweat glands in the hands and feet?
Parasympathetic; cholinergic
Parasympathetic; adrenergic
Sympathetic; cholinergic
Sympathetic; adrenergic
Sympathetic; cholinergic
Which of the following acts as an antihypertensive agent by being uptaken by adrenergic neurons and replacing norepinephrine in the synaptic vesicles?
Methoxamine
Albuterol
Guanethidine
Phenoxybenzadine
Guanethidine
The greater splanchnic nerve originates from spinal cord levels T5-T9. Which of the following statements concerning the nerve is correct?
It is composed of myelinated fibers and synapses in the superior mesenteric ganglion
It is composed of postganglionic fibers and terminates within the wall of the gut tube
It is composed of myelinated fibers and synapses in the celiac ganglion
It is composed of preganglionic fibers and synapses in the superior mesenteric ganglion
It is composed of myelinated fibers and synapses in the celiac ganglion
Beta-3 Receptors are involved in which of the following functions?
Adrenergic, Thermogenesis
Adrenergic, Glycogenolysis
Adrenergic, Cardiac Acceleration
Adrenergic, Vasoconstriction
Adrenergic, Thermogenesis
Norepinephrine is synthesized from which of the following?
Glycine
Tyrosine
Threonine
Alanine
Tyrosine- Thyroxine is also synthesized from tyrosine
Which of the following responses would not be part of the alarm response?
Increased arterial pressure
Increased glycogenesis
Increased blood glucose concentration
Increased mental activity
Increased glycogenesis