EXAM 3 Review Flashcards
In the liver, blood flow through the
DUCTUS VENOSUS
When Ductus Venosus closes remnant is
LIGAMENTUM VENOSUS
Foramen Ovale closes and becomes the
FOSSA OVALIS
When Ductus Arteriosus closes it becomes
LIGAMENTUM ARTERIOSUM
DUCTUS venosus shunt is
LIVER
Foramen ovale shunt is
Right atrium to left atrium
Ducturs arteriosus shunt is CONNECTION between
Pulmonary artery to AORTA
Fetal blood Oxyhemoglobin dissociation curve
↓ 2,3 DPG, shift to the left (Left for LOVE of oxygen) increased affinity for oxygen (hold on to oxygen)
Womb approx hgb
15g/dL
Fetal PO2 max is
50-60mmhg
Fetal blood and CO2 relationship
less affinity for CO2
Highest possible baby SPO2 is
90%
For a PaO2 of 60 what is the SPO2 approx?
90%
For a PaO2 of 50, what is the SPO2 approx?
80%
In the fetal circulation, Hgb binding is (increased/decreased)
Increased
Parallel circuit in the fetal circulation
Both right and left venticles provide systemic blood flow
In fetal circulation, PVR is
High
In fetal Circulation, SVR is
Low
What is the ratio of R to left contribution in fetal circulation
2:1 Right to left ration
Right is 2x LV output because of R to L shunt
The ductus venosus receives blood
Inferior vena cava coming from lower extremities
Where does the first admixture occur
in the Ductus venous in the liver
The presence of which structure makes the SVR low in the fetal circulation?
Placenta
Immediately after delivery, the removal of the placenta leads to what changes?
ELEVATED SVR
Most of the oxygenated blood in fetal circulation comes from ?
UMBILICAL VEIN from PLACENTA
Where does blood/ nutrients exchange occur?
In the INTERVILLOUS SPACE
Explain blood flow in fetal circulation
Path of oxygenated blood from placenta
- OXYGENATED: From placenta, blood flow through umbilical vein which separates into 2 branches (one is portal vein, the other is DUCTUS VENOSUS, which join the IVC
- The blood bypasses the liver, goes through the Ductus venosus into the IVC
- Blood enters RA
- Goes from RA through FORAMEN OVALE to LA
- From LA to LV
- From LV to proximal aorta then supplied to the coronaries and Head vessels and upper torso
Fetal blood in the
Chorionic villi
What are the 4 shunts
Ductus Venosus :
Foramen Ovale : right atrium to Left atrium
Ductus Arteriosus: pulmonary artery to Aorta
What are the 4 shunts
Ductus Venosus : Joins IVC blood, blood bypasses liver
Foramen Ovale : right atrium to Left atrium
Ductus Arteriosus: pulmonary artery to Aorta
Placenta
Path of UNOXYGENATED blood in fetal circulation
- flow directly from Superior vena cava to tricuspid to Right ventricle
- From RV to Pulmonary artery
Path of UNOXYGENATED blood in fetal circulation( blood from body)
- flow directly from Superior vena cava to tricuspid to Right ventricle
- From RV to Pulmonary artery
- Because lungs not inflated , and PVR is high, most of the DEOXYGENATED blood return to AORTA via the DUCTUS ARTERIOSUS
- Then from the aorta FLOW to UMBILICAL ARTERIES
- FROM UMBILICAL ARTERIES back to PLACENTA
What maintains DA potency ?
Prostaglandings
How can hypoxemia leads to PDA?
Hypoxemia will release endothelial nitric oxide which will results in vasoilation, may OPEN PDA after closure
What medication is given to attempt to close PDA?
Indomethacin (blocks PGE1, prostaglandins)
Functional closure of shunt happens
Immediately after birth
What causes the dramatic increase in SVR in postnatal circulation ?
Removal of placenta
What causes the dramatic decrease in PVR in postnatal circulation?
INFLATION of the lungs with the first breath
What pressure must be generated to fully expand lungs
40-60 cm H2O
In maternal circulation what is the direction of the Oxyhemoglobin curve?
↑ 2,3 DPG, Shift to the Right ( R- for RELEASE O2) lower O2 affinity)
Foramen ovale in fetal circulation closes due to
Increase in LVEDP (Left ventricle End diatole Pressure)
Functional closure of shunt happens
immediately
Does mother and Baby blood ever mix?
No
90 % of placental blood flow through which structures
Intervillous space
Properties that facilitate placental transfer
High lipid solubility
Low molecular weight
Lipophillic
CO2 is present in the form of ? Give percentage
62% of CO2 is in the form of BICARBONATE (HCO3-)
Placental O2 consumption rate
8ml/min/kg of FETAL WEIGHT
Efficiency of placenta compared to lungs
1/5th the efficiency of adult lung
The Placenta is supplied by 2 arteries which are
UTERINE and OVARIAN arteries
Uterine blood flow is
Directly proportional to the fetal umbilical venous partial pressure of O2
These arteries may bleed after placental removal
Spiral arteries
What can worsen spiral arteries bleeding after removal of placenta?
Nitrous oxide
Connect placenta to uterus
Spiral arteries
Uterine blood flow formula
Uterine arterial- venous pressure / Uterine Vascular resistance
Perfusion pressure relationship with Uterine Blood flow
Direct relationship (as one increases, the other increases)
Vascular resistance and Uterine Blood flow
INVERSE PROPORTIONAL relationship (as VR increases, UBF decreases vice versa)
2 main determinants of UBF
Perfusion pressure and vascular resistance
UBF at term is
> 700-900 ml/min
Uterine blood vessels are _________to vasopressors than systemic blood vessels
More sensitive
Vasodilators that may dilate uterine vessels
Nitrous oxide
PGE (prostanglandins)
What is altered in pregnancy as vasoconstriction?
Hypertensive response to IV epinephrine, phenylephrine and Angiotensin II is diminished
This receptor altered in pregnancy
Altered receptor mediated G-protein coupling
Placental transfer requiring ATP (2)
Active transport
Pinocytosis
Placental transfer NOT REQUIRING ATP
Passive transport
Facilitated transport
Placental transfer is LIMITED To
FLOW
Placental transfer is not limited to
diffusion
Placental transfer : passive transport driven by (COMLDM)
Concentration gradient Occurs via membrane or protein Molecular weight Lipid solubilty Degree of ionization Membrane surface area
Passive process requiring carrier protein
Facilitated transport
Determinants of ACUTE changes in UBF are
Systemic Blood pressure
Uterine venous pressure
Uterine Vascular resistance
The 3 Determinants of ACUTE changes in UBF are
Systemic Blood pressure
Uterine venous pressure
Uterine Vascular resistance
Best positions for UBF
Prone- best (i.e on all four extremities)
Left LATERAL TILT
Worst position for UBF
SUPINE
Why is supine position worse for the pregnant female?
AORTAL CAVAL Compression: Gravid uterus sitting on top of major vessels, decreases preload and venous return which decreases CO and lead to hypotension
HYPOTENSION in pregnant ladies associated with
VOMITING
Which medication can be given IM to prevent vomiting
EPHEDRINE IM 50mg
These 2 hormones increases vascular resistance leading to decrease perfusion
Vasopressin
Angiotensin II
Factors that decrease UTERINE arterial presure
Supine position
Hemorrhage/ hypotension
Drug induced hypotension
Hypotension during sympathetic Blockade
Factors that increase UTERINE PRESSURE
Venal caval compression
UTERINE CONTRACTION
Drug induced uterine hypertonus (oxytocin, cocaine)
Skeletal muscle hypertonous
Most common cause of UTERINE PRESSURE increase is
Uterine contractions
2 major thing in summary decreasing perfusion pressure
Decrease Arterial pressure
Increase uterine venous pressure
Causes of Decrease uterine Blood flow
- Endogenous vasoconstrictors (catecholamines, vasopressin)
2. Exogenous Vasoconstrictors ( Phenylephrine> ephedrine) high concentrations of local anesthetics
Uterine blood flow if often reduce clinically (P-DUE) 4 factors
Position
Drug induced HYPOTENSION
UTERINE CONTRACTIONS and PUSHING EFFORTS
Endogenous and Exogenous vasoconstrictors
PaO2 of 60 gives SPO2 of
90
Diffusion rate of O2 vs CO2
CO2 has a high diffusion capacity, 20x greater than O2
Progesterone in pregnancy direct effect
Dilation of airways
***Progesterone on CO2
Increased sensitivity of CENTRAL CHEMORECEPTORS to CO2
Progesterone in pregancy indirect effect
Enhances B2 agonist activity
**Progesterone and MAC
It decreases MAC requirement by 30 %
If progesterone decreases MAC by 30%, if the MAC is 1.4 what would be the new MAC?
1.4 (0.30) = 0.42 so 1.4-0.42 = 0.98
Hormonal changes due to 4 main hormones (PECR)
Progesterone
Estrogen
Cortison
Relaxin
Action of Cortison and Relaxin
Dilates airways
Pregnancy and Estrogen
High local ESTROGEN leads to a DIMINISHED in activity of KEY intracellular enzymes that mediate vasconstriction
Plasma volume changes secondary to hormones
Increases due Progesterone and Estrogen
Progesterone and GI
Esophageal peristalsis/intestinal transit are slowed
due to Progesterone
_____And _______ are minimally affected if at all?
Gastric acid content and plasma gastrin levels
Progesterone on Kidneys and ureters
Kidneys enlarge and the ureters/renal pelvis dilate
Kidneys enlarged due to
Progesterone
Ureter and renal pelvis dilate due to
Progesterone
Estrogen increases ____% which leads to ______
What other thing causes renin release beside Estrogen?
100%; renin releases from juxtaglomerular cells of nephron cleave angiotensinogen
Sympathetic input
Pregnancy induced ↑ forgetfulness due to
Progesterone
Alveolar anesthetic concentrations rise fastersecondary to
- ↑ MV
* ↓ FRC
Progesterone increases by _____% which leads to _________
Increase aldosterone levels
2 Actions of aldosterone
Increase sodium and water reabsorption by nephron collecting duct →Increase effective blood volume to correct initial stimulus to the system
Vicious cycle of persistent Fetal circulation (HPIR)
- hypoxia/hypercabnia/acidosis/ cold
- Pulmonary vasoconstriction
- Increased pulmonary vasoconstriction
- RIGHT TO LEFT SHUNTING of BLOOD
Back to number 1.. vicious cycle
What is the danger of persistent fetal circulation
Can pop open foramen ovale and return circulation to fetal circulation
Estrogen and endocrine
Increase plasma cortisol during 1st trimester by 100%
by 200% by term
Joint mobility and pregnancy
RELAXIN increase joint mobility
Blood glucose and pregnancy
LACTOGEN; reduces tissue sensitivity to insulin
Which hormone reduces tissue sensitivity to insulin during pregnancy ?
Lactogen
What changes in occur in MV in pregnancy ?
MV increase by 50%
The MV ventilation is because of _____not _____
TV increase by 45%, NOT RR
RR with pregnancy
remains the same
Pregnancy O2 consumption and Co2 production
O2 consumption and CO2 production increases by 60%
primary due to fetus, uterus and placenta
secondary due to cardiac/resp work
Diaphram changes during pregnancy
FLATTER and Higher
Inspiration at term is TOTALLY
Diaphragmatic
Respiration at term dependent of PHRENIC NERVE which is
C3, C4, C5
FRC and pregnancy
Decreases by 20%
FRC is reduced TO
80%
Why does FRC decreases? What is the meaning of a decreased FRC?
because Diaphragm is higher
Less O2 reserve , less time to intubate, desaturation occurs quicker. MUST PRE-OXYGENATE
When does FRC changes start?
by the 5th month
These 2 respiratory paramaters remains the same during pregnancy
Vital capacity
RR
FRC is combination of ___ and _____
% decrease of each ?
ERV 25%
RV 15%
Critical FRC point any further you loose ability to ventilate
- Pneumonia
- Pulmonary edema
- ARDS
PaCO2 decreases due to
• ↑ TV/MV
PaCO2 in pregnancy _____ by when?
Decrease PaCO2 to 30 mmHg by 12 weeks
What compensate for the decrease of PaCO2 ?
Bicarbonate decreases to ~ 20 mEq/L to compensate for the reduced PaCO2
pH in pregnancy
Slightly alkalotic
PaO2 level during pregnancy 1st, 2nd, 3rd respectively
107 - 105- 103
pH blood gas level 1st, 2nd,3rd
7.44
Bicarb pre-pregnant levels
24
Bicarb during pregnancy, 1st, 2nd,3rd respectively
21-20-20
PaCO2 pre-pregnant
40
PaCO2 gas level 1st, 2nd,3rd
30
Which hormones may account for back pain and carpal tunnel syndrome during pregnancy ?
Relaxin
Thoracic age and pregnancy
Increases in size
This hormone is a respiratory stimulant
Progesterone
Hormone responsible for the decreased PaCO2
Progesterone (stimulate respiration)
Pregnancy and Local anesthetics changes
increase sensitivity to local anesthetics due to progesterone increase
Progesterone causes
Capillary engorgement and nasal passageway swelling
Recommended ETT tube size
6.5mm
Avoid in pregnant patient as far as UPPER airways
Any nasal NG, nasal airway or oral airway due to AIRWAY SWELLING
Highest maternal mortality associated with
Difficult intubations
Mallampati scores and pregnancy
Increases
Denitrogenation is more
rapid due to increase MV and decrease FRC
In pregnancy • PaCO2 of 40mmHg leads to
acute respiratory acidosis
• FRC ↑ but below normal up until
1-2wks postpartum
How long does it take for TV, MV and O2 consumption remain elevated
up to 6 weeks
CV: issues Murmur associated with pregnancy
Grade I-II systolic murmur is typically heard; usually TR or MR
Regurgitation with pregnancy
Tricuspid regurgitation 94% and Mitral
Pulmonary compliance and pregnancy
Pulmonary compliance DECREASES
Thoracic compliance during pregnancy
Thoracic compliance INCREASES
NO effect on this respiratory parameters
FEV, FEV1/FRC, Flow volume loop or CLOsing capacity
NO effect on this respiratory parameters
FEV, FEV1/FRC, Flow volume loop or closing capacity
Obese and pregnant patient will show
RESTRICTIVE pattern
Supine position decrease PaO2 by
Reducing FRC
Closing small airways
Increase shunt
Reducing CO via Aortacaval compression
Types of hypertrophy normal in pregnancy
LVH
Pulmonary pressure and pregnancy
Elevated
EKG changes and pregnancy
Sinus tachycardia with short PR
When is the CO the highest in pregnancy
Immediately after delivery 75%
When is the SV the highest in pregnancy
Immediately after delivery 75%
IS the pregnant female at risk for AORTIC DYSFUNCTION?
No
CO and pregnancy and distribution of change
CO increases by 50%
HR increase by 25%
SV increase by 25%
EF and pregancy
LVEDP increases , EF increases
Pulse pressure and pregnancy
Widening pulse pressure
ORGANS with increase perfusion are (KUE)? any other organs affected?
Kidneys
Uterus
Extremities
NO
What happens during Aorto Caval Compression
Aorta is partially obstructed
In supine position aorta is (IPCR)
Increased femoral venous pressure
Partially obstructed
Collaterals cannot maintain venous return
Right side pressure Fall
In Lateral Decubitus Position (PCA)
Partial caval obstruction
Collateral MAINTAIN venous return
AORTA is unaffected
BEST POSITION if can’t do prone
LATERAL DECUBITUS POSITION
Collateral veins that maintain venous return when patient in lateral decubitus position (IPE)
Intraosseous vertebral vein
Paravertebral vein
Epidural venous plexus
Aortocaval compression preload is
Decreases 10-20%
Uterine blood flow and aortocaval compression
Decreases by 20%
Lower extremities flow and aortocaval compression
falls by 50%
SUPINE HYPOTENSIVE SYNDROME is
From the profound drop in VENOUS RETURN from which the CV system CANNOT COMPENSATE
There is rising pulse pressure because
Diastolic pressure lower due to low resistance vascular intervillous space and homone induced vasodilation
Supine position associated with
Hypotension → vomiting
Bradycardia
SV increased in pregnancy is mostly due to
Preload
Spinal anesthesia CSF volume and pregnancy
↓ spinal CSF volume
Spinal Anesthetic Requirements and pregnancy
•Reduced by 25%
High spinal and epidural catastrophic
- Check hands
* C6
Fasting gastric volume and pH are normalized by
18hrs postpartum
IF patient start to have contractions
STOP all neuraxial anesthesia process (can cause wet tap - hit spinal –> headaches)
Renal plasma flow, GFR, and creatinine clearance all
↑
Renal plasma flow, GFR, and creatinine clearance all normalize by
8-12 wks PP)
Returns toward pre-pregnant sympathetic tone by
24-48 hrs
Epidural vein and pregnancy
•Distension of Epidural Veins
Regional and Pregnancy
LOCAL Anesthetics requirement lowered
Do Left lateral
before spinal anesthesia
Do Left lateral position
before spinal anesthesia
This medication is unaffected by pregnancy
Propofol
Epidural pressure and pregnancy
↑ EPIDURAL PRESSURE
Pneumatic space and ↓ spinal CSF volume and pregnancy
• ↓ SPINAL CSF and pneumatic space
Preoxygenation for pregnant can lead to PaO2 500mmHg which allows
3 mins of apnea
First stage of labor
onset of true labor until cervix is completely dilated (10 cm)
Subdivision of first stage of labor
Early labor phase: time of onset until cervix dilated
3cm
Active labor phase: cervix dilates from 3cm to 7cm
Transition phase: cervix dilates from 7cm to 10 cm
Second stage of Labor
period after cervix dilated to 10cm until the baby is delivered.
Third stage of Labor
Delivery of the placenta.
1st stage of labor what type of pain
Visceral
1st stage Dull pain transmitters are the
Cervical dilation mediated by
unmyelinated C fibers
1st stage pain comes from
T10-L1(L2) DERMATOMES
Second stage
Cervical dilatation progresses
Fetal head descends into pelvis
Stretches and compresses pelvic structures
In second stage pain is mediated by
THE SACRAL PLEXUS
T12-L1, S2-S4
This nerve block provides sensory to perineum
PUDENTAL BLOCK
Not always completely anesthetized with epidural
The Pudental NERVE
Third Stage of Labor
Placental EXPULSION
Which anesthetic block is better during SECOND stage of labor?
Pudental Block (rarely done, high risk)
MAC return to normal when?
72 hours (3 days) postpartum
Patient return had baby 3 days ago, do you need to alter MAC?
no
Dull, diffuse midline define
Visceral
Sharp, pricking, throbbing,and/or burning sensation
Somatic
Increase sensitivity to
YOU NEED LESS
-curonium
Ester Benzoisoquilines
Despite increase clearance
Onset of perineal pain is associated with which stage of labor?
2nd stage
Appropriate analgesia for FIRST stage labor
Neuraxial, Paravertebral and Paracervical
Associated with the most FETAL BRADYCARDIA
PARACERVICAL (especially with bupivacaine)
Less spinal due requirement due to
thoracic Kyphosis apex is higher (stopping use from apnea)
Decreased normal dose of LOCAL Anesthetics start during
2nd trimester
Regional more difficult due to
Lombar lordosis
When does requirement of LOCAL anesthetics return to normal ?
40 hours postpartum
Obstetric History
Gravity = # of conceptions Parity = # of live births Abortus = # of preterm dead birth
G1 P2 means
TWINS
Any regional will decrease
FRC
ASSESS NEURO C6 gives you the ability to do
put 2 fingers together with hands
Watch for signs of respiratory depression
_____________ has a poor predictive value for abnormal outcome
Abnormal FHR
Historical RISK FACTOR For abnormal outcome
SUWAN
Smoking Unmarried Weight < 50 kg Age <18 or >39 years No education beyond primary
Past OB risk factor for Abnormal outcome
PIP
Hx of perinatal loss
Hx of infant < 2500gms
Hx of preterm birth (<28 weeks gestation)
Past MEDICAL hx risk factor for abnormal outcome
RRP TC
Rh negative with antibodies Renal disease Previous cone biopsy Thyroid disease Cardiac disease
During Pregnancy; RISK FACTOR FOR negative outcome
MAH 4Ps GBD
Multiple gestation Anemia HTN Pyelonephritis Proteinuria Placental abruption Placenta previa Gestational or Established Diabetes Bleeding before 28 weeks gestation Delivery before 37 or after 42 weeks gestation
PROM
PREMATURE RUPTURE OF MEMBRANES
PPROM
PROM + PREMATURITY
• > 34 WEEKS =
INDUCE AND DELIVER
• < 31 WEEKS: EXPECTANT MANAGEMENT
EXPECTANT MANAGEMENT with prophylatics ABTs, tocolytics, and glucocorticoids (to accelerate lung maturity)]
Can lead to Chorioamnionitis
ACOG RECOMMENDATIONS for PROM• IN BETWEEN
= EVALUATE FETAL LUNG MATURITY
• ANTIBIOTIC PROPHYLAXIS
VBAC
ONLY CALLED VBAC ONCE YOU DELIVER
VBAC is TECHNICALLY TOLAC:
TRIAL OF LABOR AFTER CESAREAN
VBAC precluding Factors (UNMI)
FACTORS: • UNSUCCESSFUL TOLAC • NO PREVIOUS VAGINAL BIRTHS • MULTIPLE CS • INDUCED/AUGMENTED LABOR
VBAC successful with patient with a
LOW transverse INCISION
Risks with VBAC
Uterine Rupture less than 1% with low transverse
RIsk VBAC compared to elective CS and Failed TOLAC
Risk (better to worse)
VBAC> Elective repeat CS > Failed TOLAC
Interpreting causes of Fetal HR changes
VEAL CHOP Variable Decels - Cord Compression Early decels - Head Compression Accelerations -- Ok or give Oxygen Late decels --- Placental Insufficiency
2 predictor of POOR fetal status
Sinusoidal pattern
Absent baseline variability
Who needs preop regardless epidural or not
Above 24 weeks
Variability of FHR means
Reassuring pattern
Normal neurologic function of fetus parasympathetic and sympathetic functions
Best position is
occiput anterior (baby kissing mom)
Loss of resistance with needle indicates
Epidural space
Can cause transient neurological symptoms
LIDOCAINE
General assssment
maternal health history
Obstetric history
Anesthesia related to obstetric hx
NPO and obstetric
All patients are considered full stomach and at risk for pulmonary aspiration
Supine position should be avoided unless a
LEFT UTERINE DISPlACEMENT device (>`15deg) wedge is placed UNDER THE RIGHT HIP
Most common cause of Neonatal depression
Intrauterine asphyxia
Preferred anesthesia
Spinal or EPIDURAL (less hemodynamic fluctuation, gradual resolution and lower maternal mortality
Sings of fetal compromiss
Absence of baseline variability and accelerations
More prolonged and Painful labor
OCCIPUT POSTERIOR (manuel or forceps rotation for delivery)
Epidural activation for first stage of labor
3ml test dose with local anesthetic 1:200000 epi
less toxicity in case of UNINTENTIONAL INTRAVASCULAR INJECTION
Administer between contraction
Wait 5 minutes, with patient supine and Left uterine displacement
Dosing for initial boulus
10ml in 5ml increments
- 1% to 0.2% ropivacaine
- 0652% to 0.125% Bupivacaine combined with 50-100mcg fentany or 10-20mcg of sufentanyl
DA Functional Closure –
12 hours
DA Physiologically Closed
48 hours
DA Permanent Anatomic Closure
2 wks
Sensitive to DA
Oxygen, pH, & prostaglandins
• ↑ PaO2
• Less acidic pH
• Loss of placental prostaglandins
Ductus Venosus Ligamentum Venosum
• Shunts blood from liver to IVC - 50% or less
• Closes within 7 day
DV