Exam 3 (PDF pages 43-62)

Question 1

Most malignant bone tumors are metastatic….

Answer 1

carcinomas

Question 2

True/false: sarcomas often hemorrhage and metastasize early?

Answer 2

true

Question 3

what are the characteristics of malignant bone tumors? (general)

Answer 3

-bone destruction/lysis
-irregular, ragged, frayed margins of the lesion/poor zone of transition
-cortical erosion + destruction
-soft tissue masses may be present in adjacent area
-irregular “cloud” of increased bone density or lucent areas
-periosteal reactions
-systemic evidence of metastasis
-pain = moderate-severe
-alterations in blood chemistry

Question 4

Which tumor is this?
-malignant mesenchymal tumor derived from fibrous CT
-invades long or flat bones (femur,tibia, mandible)
-involves periosteum and overlying muscle
-common age range is 30-50
-can produce a large soft tissue mass and present clinically w/ localized pain/swelling

Answer 4

Fibrosarcoma

Question 5

which bone type is involves with 70% of fibrosarcoma cases

Answer 5

long bones (distal femur #1, proximal tibia #2)
-w/ metaphyseal lesions being the most common
-extension into the diaphysis or epiphysis is also common

Question 6

what are the 4 primary malignant bone tumors/bone sarcomas

Answer 6

1. multiple myeloma
2. osteogenic sarcoma/osteosarcoma
3. chondrosarcoma
4. ewing’s tumor/ewing’s sarcoma

Question 7

what is the most common primary malignant bone tumor

Answer 7

multiple myeloma