Exam 3: Opioids

Question 1

What is meperidine?

Answer 1

Synthetic opioid introduced in 1939.

Question 2

What is methadone?

Answer 2

Introduced in 1946; known for prolonged QT interval, long duration, and blocking NMDA receptors.

Question 3

What is nalorphine?

Answer 3

Introduced in 1942; counteracts the effects of morphine and produces limited analgesia.

Question 4

What are opiates?

Answer 4

Opiates are derived from opium, including morphine, codeine, and a variety of related alkaloids.

Question 5

What is an opioid?

Answer 5

An opioid includes all agonists and antagonists with alkaloid structures, as well as naturally occurring and synthetic peptides that bind to opioid receptors.

Question 6

What is a narcotic?

Answer 6

A narcotic is any drug that induces sleep; it was originally used to describe strong opiate analgesics and now refers to a wide variety of opioid and non-opioid abused substances.

**Footnote
Controlled Substances are better to call

Question 7

What are the types of opioid binding sites in the CNS?

Answer 7

Mu, kappa, delta