Exam 3- Exercise Physiology Flashcards
The average VO 2 max value for the young (e.g., 21 years old) male sedentary
population is approximately
A) 45 ml * kg -1 * min -1.
B) 35 ml * kg -1 * min -1.
C) 22ml * kg -1 * min -1.
D) 83 ml * kg -1 * min -1
A) 45 ml * kg -1 * min -1.
Endurance exercise training programs (e.g., 3 days/week @ 60% VO 2 max for 12
weeks) typically results in a ______
A) 1-5% improvement in VO 2 max
B) 15-25% improvement in VO 2 max
C) 5-10% improvement in VO 2 max
D) 40-60% improvement in VO 2 max
B) 15-25% improvement in VO 2 max
Cross-sectional studies demonstrate that the physiological variable responsible for the
large variation in VO 2 max across the normal (untrained) population is maximal
A) heart rate.
B) stroke volume.
C) arteriovenous O 2 difference.
D) systolic blood pressure.
B) stroke volume.
Heritability (i.e., genetics) determines approximately _____% of VO 2 max variability in
sedentary adults.
A) 20
B) 50
C) 30
D) 90
B) 50
Endurance training has been shown to reduce the oxygen deficit in subjects performing a
bout of submaximal exercise. This is likely due to
A) an increased maximal cardiac output.
B) increases in the number of mitochondria and capillaries.
C) a decreased resting heart rate.
D) a greater anaerobic capacity.
B) increases in the number of mitochondria and capillaries.
The heart rate and ventilatory responses to constant load submaximal exercise are lower
(i.e., lower heart rate and lower minute ventilation) following an endurance training program.
This training-induced adaptation is primarily due to changes in the
A) central nervous system.
B) carotid bodies.
C) trained skeletal muscles.
D) lungs.
C) trained skeletal muscles.
During the first four months of an endurance exercise training program, the initial
increase in VO 2 max is primarily due to
A) increases in stroke volume.
B) neural adaptations.
C) increases in maximal cardiac output.
D) Both increases in stroke volume and increases in maximal cardiac output are correct.
B) neural adaptations.
Which of the following factors do not contribute to the endurance exercise training induced improvement in VO 2 max?
A) increased maximal cardiac output
B) increased maximal stroke volume
C) increased maximal heart rate
D) None of these answers is correct
C) increased maximal heart rate
Endurance training results in increased mitochondrial and capillary density in muscle but
has no effect on muscle glycolytic capacity. This is an example of what training principle?
A) overload
B) specificity
C) reversibility
D) none of these
B) specificity
High responders to endurance exercise training (i.e., individuals that achieve large
increases in VO 2 max) can achieve up to ______% improvement in VO 2 max following a
prolonged and intense training program.
A) 20
B) 35
C) 90
D) 50
D) 50
The removal of damaged mitochondria in skeletal muscle and other cells is called
A) mitogenesis.
B) mitophagy.
C) mitochondria endocytosis.
D) mitochondrial exocytosis.
C) mitochondria endocytosis.
Following several weeks of endurance exercise training, the capacity to transport glucose
into skeletal muscle fibers is increased. Which of the following training-induced changes
contribute to this training effect?
A) an increase in mitochondria within muscle fibers
B) the increase in the number of GLUT4 glucose transporters
C) an increase in circulating catecholamines
D) a decrease in circulating insulin
B) the increase in the number of GLUT4 glucose transporters
Four-to-ten weeks of anaerobic training (high intensity exercise lasting 10-30 seconds)
can increase the peak anaerobic capacity by ______ across individuals.
A) 30-40%
B) 50-60%
C) 3-25%
D) 65-75%
C) 3-25%
The increase in VO 2 max that occurs following 16 months of endurance exercise
training results from
A) an increase in the maximal a-vO 2 difference.
B) an increase in maximal cardiac output.
C) an increase in the maximal heart rate.
D) both an increase in the maximal a-vO 2 difference and an increase in maximal cardiac output are correct
D) both an increase in the maximal a-vO 2 difference and an increase in maximal cardiac output are correct
Following an acute bout of endurance exercise training, the rise in the activity of
calcinuneurin, calmodulin kinase, and AMP kinases occurs within _____ following the exercise
session.
A) seconds
B) minutes
C) hours
D) days
B) minutes
Following an acute bout of endurance exercise training, the increase in mitochondrial
biogenesis occurs within _____ following the completion of the exercise session.
A) seconds
B) minutes
C) hours
D) days
C) hours
Endurance exercise training results in an increase in mitochondria volume within skeletal
muscle fibers. The process of synthesizing mitochondria in cells is called ______.
A) mitophagy
B) mitochondrial proteostasis
C) mitochondrial biogenesis
D) none of these answers is correct
C) mitochondrial biogenesis
The principle of specificity of training refers to the fact that exercise training is specific to
A) the muscles involved in the activity.
B) the fiber types recruited.
C) the principal energy system (i.e., aerobic vs. anaerobic) involved in the activity.
D) all of these are correct.
D) all of these are correct.
Which of the following physiological factors does NOT contribute to the endurance
exercise training-induced increase in the maximal a-vO 2 difference?
A) increased mitochondria volume in the muscle
B) increased capillaries in the muscle
C) increased muscle blood flow
D) increased hemoglobin in the blood
D) increased hemoglobin in the blood
The enhanced capacity of the trained muscle to use fatty acids as a fuel results in
A) increased uptake of fatty acids.
B) decreased utilization of muscle glycogen.
C) sparing of blood glucose.
D) all of these answers are correct.
D) all of these answers are correct.
Which of the following factors does NOT contribute to the endurance exercise training induced improvement in stroke volume during exercise?
A) increased end-diastolic volume
B) increased peripheral resistance
C) increased cardiac contractility
D) decrease in total peripheral resistance
B) increased peripheral resistance
Which of the following endurance training adaptations does NOT result in lower lactate
production in the contracting muscles?
A) increased glycogen utilization
B) increased H 4 form of LDH
C) increased mitochondrial uptake of pyruvate
D) decreased pyruvate formation
A) increased glycogen utilization
Which of the following training adaptations does NOT occur in skeletal muscles
following 4-10 weeks of anaerobic exercise training?
A) increased muscle buffer capacity
B) increased activities of myokinase and creatine phosphokinase
C) increased activities of key glycolytic enzymes
D) None of these answers is correct
D) None of these answers is correct
Which of the following factors DO NOT contribute to the decline in VO 2 observed
during 84 days of detraining?
A) A decrease in maximal heart rate
B) A decrease in the maximal arterial-venous O 2 difference
C) A decrease in maximal stroke volume
D) None of these is correct
A) A decrease in maximal heart rate
Which of the following factors DO NOT contribute to the endurance exercise training induced increases in fat metabolism during exercise?
A) slower blood flow in muscle
B) increased fat storage in the liver
C) increased FFA transporters
D) increased beta oxidation enzymes
B) increased fat storage in the liver
Which of the following endurance training adaptations assist in maintaining acid-base
balance during exercise?
A) increased mitochondrial volume in skeletal muscle
B) increased M 4 form of LDH
C) increased glycolytic capacity
D) decreased beta oxidation capacity
A) increased mitochondrial volume in skeletal muscle
Which of the following statements are true about the effect of endurance training or
detraining on mitochondria volume in human skeletal muscle?
A) Five weeks of endurance training can increase skeletal muscle mitochondrial
volume by two times about normal.
B) Seven days of detraining can reduce mitochondrial volume by 50% below the
trained level.
C) After a period of detraining, approximately 4 weeks of retraining is required to
regain the lost mitochondrial volume.
D) All of these are true.
D) All of these are true.
Aging is associated with a decline in strength, with most of the decline occurring after
age 50. The loss of strength is due, in part, to a loss of muscle mass; this age-related loss of
muscle mass is termed
A) sarcopenia.
B) muscle fiber hypotrophy.
C) muscle fiber hyperplasia.
D) None of these is correct.
A) sarcopenia.
Which of the following statements about resistance training is NOT true?
A) Resistance training results in hypertrophy and strength gains in people aged 13-65
years old.
B) Resistance training results in hypertrophy and strength gains in young men and
women less than 39 years old.
C) Resistance training results in hypertrophy and strength gains in people of all ages.
D) Resistance training DOES NOT promote hypertrophy and strength gains in
people greater than 65 years old.
D) Resistance training DOES NOT promote hypertrophy and strength gains in
people greater than 65 years old.
Muscles receive a neural activation signal from motor neurons located in the spinal cord.
This neural signal is referred to as ________.
A) motor learning
B) efferent control
C) neural drive
D) motor endplate activation
C) neural drive
A muscle (i.e., prime mover) that results in movement of a limb in the desired direction is
labeled as _____________.
A) an antagonist
B) an agonist
C) a promoter
D) none of these is correct
B) an agonist
During the first 8 weeks of a resistance training program, the initial increase in muscular
strength is primarily due to
A) neural adaptations.
B) muscle fiber hypertrophy.
C) muscle fiber hyperplasia.
D) Both muscle fiber hypertrophy and muscle fiber hyperplasia are correct.
A) neural adaptations.
A single bout of resistance exercise training increases muscle protein synthesis by as
much as ______% above resting levels?
A) 20-30
B) 50-150
C) 35-45
D) 200-300
B) 50-150
Following a single bout of resistance exercise training, muscle protein synthesis can
remain elevated above sedentary levels for as much as ______ in both trained and untrained
individuals.
A) 10-15 hours
B) 15-20 hours
C) 35-50 hours
D) 20-25 hours
C) 35-50 hours
A single bout of resistance exercise training results in an increase in skeletal muscle
protein synthesis. This exercise-induced increase in muscle protein synthesis can occur within
_____ following the exercise session.
A) seconds
B) minutes
C) hours
D) days
C) hours
The term cross-education refers to ___________________.
A) the observation that if one limb engages in resistance training, muscular strength
increases in the untrained (contralateral) limb
B) the observation that if one limb engages in resistance training, muscular strength
does NOT increase in the untrained (contralateral) limb
C) the observation that if one limb engages in resistance training, muscular strength
decreases in the untrained (contralateral) limb
D) None of these is true
A) the observation that if one limb engages in resistance training, muscular strength
increases in the untrained (contralateral) limb
Neural drive is defined as ___________________________________.
A) the size of the motor units activated during muscular contraction
B) the magnitude of the efferent neural output from the central nervous system to the motor units and the muscle fibers that they activate
C) the amount of afferent feedback to the central nervous system during exercise
D) the amplitude of the neural output from the cerebellum during exercise
B) the magnitude of the efferent neural output from the central nervous system to the motor units and the muscle fibers that they activate
An important physiological factor that may contribute to the inhibition of motor unit
activation during resistance training is ____________.
A) the muscle spindle
B) the inhibitory neurotransmitter acetylcholine
C) the Golgi tendon organ
D) both the muscle spindle and the Golgi tendon organ are correct
C) the Golgi tendon organ
Resistance training increases the specific force production of ________.
A) type I muscle fibers
B) type IIa muscle fibers
C) type IIx muscle fibers
D) all muscle fiber types
A) type I muscle fibers
The term hyperplasia refers to ________________.
A) muscle hypertrophy
B) an increase in muscle plasticity
C) an increase in the total number of muscle fibers
D) None of these is correct
C) an increase in the total number of muscle fibers
Resistance training results in a __________________.
A) fast-to-slow shift in muscle fiber types
B) slow-to-fast shift in muscle fiber types
C) decrease in the number of slow muscle fibers
D) None of these is correct
A) fast-to-slow shift in muscle fiber types
Resistance training results in an increase in the rate of contractile protein synthesis which
is matched by _________________.
A) an increase in mitochondrial protein synthesis
B) an increase in the expansion of the sarcoplasmic reticulum
C) a decrease in synthesis of antioxidant enzymes
D) an increase in the synthesis of collagen in tendons and ligaments
D) an increase in the synthesis of collagen in tendons and ligaments
A major regulator of protein synthesis and muscle size is ____________.
A) TSC2
B) the lysosome
C) tyrosine
D) mTOR
D) mTOR
Growing evidence reveals that, independent of resistance exercise, ____________ can
activate mTOR and promote small increases in muscle protein synthesis.
A) the amino acid taurine
B) the amino acid leucine
C) an increase in the muscle levels of TSC2
D) All of these are correct
B) the amino acid leucine
Several hormones have the potential to increase muscle protein synthesis. These include:
A) testosterone, insulin-like growth factor-1 (IGF-1), and growth hormone
B) testosterone, cortisol, and growth hormone
C) insulin-like growth factor-1 (IGF-1), glucocorticoids, and growth hormone
D) testosterone, insulin-like growth factor-1 (IGF-1), and parathyroid hormone
A) testosterone, insulin-like growth factor-1 (IGF-1), and growth hormone
Research reveals that resistance training induced muscle hypertrophy is associated with
an increase in myonuclei. The source of these additional myonuclei is _____________.
A) from circulating stem cells that attach to muscle fibers
B) via the division of existing nuclei in the muscle fibers
C) via hyperplasia resulting in the addition of new muscle fibers
D) via satellite cell activation
D) via satellite cell activation
It is estimated that _______% of the differences in muscle mass between individuals can
be explained by genetic variation.
A) 30
B) 50
C) 80
D) 90
C) 80
By comparison to the rate of detraining following endurance training, the rate of
detraining (i.e., loss of muscular strength) following a resistance training program is _________.
A) slower
B) faster
C) approximately equal
D) extremely rapid with 90% of the strength loss occurring within the first 10 days of
detraining
A) slower
The phenomenon that previous strength training accelerates the re-acquisition of both
muscular strength and hypertrophy is commonly referred to as _________.
A) motor learning
B) the boomerang effect
C) satellite cell phenomenon
D) muscle memory
D) muscle memory
Prolonged inactivity of skeletal muscle leads to rapid muscle atrophy; this occurs due to:
A) a decrease in muscle protein synthesis
B) increased protein breakdown in muscle fibers
C) both a decrease in muscle protein synthesis and increased protein breakdown in
muscle fibers are correct
D) None of these is correct
C) both a decrease in muscle protein synthesis and increased protein breakdown in
muscle fibers are correct
The addition of myonuclei to growing muscle fibers ______________.
A) appears to be essential for optimal muscle hypertrophy in response to resistance training
B) is clearly NOT essential for optimal muscle hypertrophy in response to resistance
training
C) is likely required to maintain the high level of transcriptional capacity needed to
synthesize muscle proteins and allow muscle fibers to grow during resistance training
D) Both appears to be essential for optimal muscle hypertrophy in response to
resistance training and is likely required to maintain the high level of transcriptional capacity needed to synthesize muscle proteins and allow muscle fibers to grow during resistance training are correct
D) Both appears to be essential for optimal muscle hypertrophy in response to
resistance training and is likely required to maintain the high level of transcriptional capacity needed to synthesize muscle proteins and allow muscle fibers to grow during resistance training are correct
In resting skeletal muscle fibers, Ras homologue enriched brain (Rheb) activation of
mTOR is inhibited by ______.
A) phosphatidic acid
B) tuberous sclerosis complex 2 (TSC2)
C) IGF-1
D) none of these answers is correct
B) tuberous sclerosis complex 2 (TSC2)
Increased production of radicals in skeletal muscles during periods of prolonged
inactivity (prolonged bedrest) and promotes muscle atrophy because:
A) oxidative stress activates proteases in muscle fibers
B) oxidative stress decreases protein synthesis in muscle fibers
C) oxidative stress prevents mTOR activation
D) All of these are correct
D) All of these are correct
Several factors contribute to neural drive. Which one of the following factors is NOT a
contributor to neural drive?
A) total number of motor units activated
B) the firing rate of the motor neuron
C) activation of the Golgi tendon organ
D) motor unit synchronization
C) activation of the Golgi tendon organ
It is established that resistance exercise training promotes an increase in muscle protein
synthesis by activating the mechanistic target of rapamycin (mTOR) which results in increased protein synthesis. Recent evidence suggests that two signaling molecules interact to directly activate mTOR. These molecules are:
A) IGF-1 and Akt
B) IGF-1 and phosphatidic acid
C) IGF-1 and Ras homologue enriched brain (Rheb)
D) phosphatidic acid and Ras homologue enriched brain (Rheb)
D) phosphatidic acid and Ras homologue enriched brain (Rheb)
Several mechanisms have been proposed to explain why concurrent endurance and
resistance (strength) training impedes strength development compared to strength training alone.
Which of the following mechanisms have NOT been proposed to explain why concurrent
training impedes strength development?
A) Neural factors
B) Overtraining
C) Depressed muscle protein synthesis
D) none of these is correct
D) none of these is correct
Several mechanisms have been proposed to explain why concurrent endurance and
resistance (strength) training impedes strength development compared to strength training alone.
Which of the following mechanisms have NOT been proposed to explain why concurrent
training impedes strength development?
A) Neural factors
B) Overtraining
C) Depressed muscle protein synthesis
D) none of these is correct
D) none of these is correct
In theory, concurrent resistance and endurance exercise training can impair muscle
protein synthesis following a bout of resistance exercise. The proposed mechanism to explain this inhibition is _____________________________________.
A) AMP kinase activation of TSC2
B) AMP kinase activation of mTOR
C) AMP kinase activation of PGC-1α
D) p38 activation of TSC2
A) AMP kinase activation of TSC2
If a 30-year-old man checked a “yes” response on the PAR-Q+, what should he do prior to
taking an exercise test?
A. nothing; he can take the test
B. answer additional questions about his health history
C. have a complete physical examination
D. check into a hospital immediately
B. answer additional questions about his health history
The basis for the running field tests for estimating VO2 max is that
A. maximal heart rate is achieved during the test.
B. the average running speed is below the anaerobic threshold.
C. there is a linear relationship between the average running speed (i.e. during maximal effort
running of 10-20 minutes duration) and maximal oxygen uptake.
D. none of the above.
C. there is a linear relationship between the average running speed (i.e. during maximal effort
running of 10-20 minutes duration) and maximal oxygen uptake.
A sign of myocardial ischemia measured on the ECG during a graded exercise test is
A. a large P wave.
B. an increase in the width of a QRS complex.
C. a depression of the ST segment.
D. a disappearance of the T wave.
C. a depression of the ST segment.
Which of the following is NOT a criterion for having achieved VO2 max during a graded
exercise test?
A. leveling off of the VO2.
B. achieving 85% of maximal heart rate.
C. a blood lactate level of >8 mmoles liter-1.
D. respiratory exchange ratio >1.15.
B. achieving 85% of maximal heart rate.
For many individuals that are not trained cyclists, the highest VO2 value is usually
measured during an exercise test to exhaustion using
A. a cycle ergometer.
B. a treadmill walk test.
C. a graded treadmill running test.
D. an arm ergometer test.
C. a graded treadmill running test.
The Bruce protocol is a graded exercise test protocol that uses the __________ to perform
the test.
A. cycle ergometer
B. arm ergometer
C. treadmill
D. step test
C. treadmill
In general, the graded exercise test (GXT) used for sedentary subjects would start at 2-3
METs and progress at about_____________ per stage.
A. 1 MET
B. 2-3 METS
C. 4-5 METS
D. None of the above answers are correct
A. 1 MET
The term arrhythmia refers to
A. an irregularity in the normal electrical activity of the heart.
B. cardiac arrest.
C. a unique form of myocardial ischemia.
D. None of the above answers are correct
A. an irregularity in the normal electrical activity of the heart.
The type of graded exercise test that is most conducive for individuals to complete at home or for testing large groups of subjects simultaneously is
A. a cycle ergometer test.
B. a treadmill test.
C. a step test.
D. an arm ergometer test.
A. a cycle ergometer test.
Angina pectoris is a ________________.
A. symptom of COPD
B. symptom of myocardial ischemia
C. symptom of respiratory muscle fatigue
D. None of the above answers are correct
B. symptom of myocardial ischemia
A sphygmomanometer may be used during a cycling exercise test to determine
A. arrhythmias.
B. conduction disturbances.
C. myocardial ischemia.
D. blood pressure.
D. blood pressure.
The term dyspnea refers to ________________.
A. abdominal discomfort
B. breathlessness
C. chest pain
D. none of the above answers are correct
B. breathlessness
The “double product” is___________________.
A. an estimate of cardiac work and oxygen demand
B. computed as the product of heart rate and systolic blood pressure.
C. a biomarker indicating that the subject has reached their maximal heart.
D. Both A and B are correct
D. Both A and B are correct
Which of the following field tests is used for children?
A. Bruce protocol
B. PACER test
C. FITNESSGRAM
D. both B and C are correct
D. both B and C are correct
The original Borg Rating of Perceived Exertion scale used the rankings from
_______whereas the revised Borg scale now uses a ranking from ______.
A. 6-12, 1-10
B. 6-18, 1-10
C. 6-20, 1-10
D. 6-20, 0-10
D. 6-20, 0-10
Which of the following specific signs would be an indication to stop a graded exercise
test?
A. Increase in heart rate with an increase in work rate
B. A decrease in blood pressure with an increase in work rate
C. Dizziness
D. Both B and C are correct
D. Both B and C are correct
Heart rate can be measured by palpating the carotid artery. Applying too much pressure to the carotid artery could impact the measurement of heart rate in which of the following ways.
A. Applying excessive pressure to the carotid artery could increase heart rate by activation of the sympathetic nervous system.
B. Applying excessive pressure to the carotid artery could decrease heart rate by way of the baroreceptor reflex.
C. Applying excessive pressure to the carotid artery could decrease heart rate by impacting venous return to the heart.
D. None of the above answers are correct
B. Applying excessive pressure to the carotid artery could decrease heart rate by way of the baroreceptor reflex
Which of the following is NOT a symptom of myocardial ischemia?
A. Depression of the ST segment of the electrocardiogram
B. Increase in the height of the P wave on the electrocardiogram
C. Pain in the jaw
D. Pain in the neck
B. Increase in the height of the P wave on the electrocardiogram
Studies have shown that VO2 max can be estimated without an exercise test by combining
a few simple variables. Which of the following variables are NOT typically used to estimate
VO2 max in a large and diverse population?
A. Age and gender
B. Body weight
C. Body fatness
D. Body mass index
B. Body weight
VO2 max can be estimated by drawing a line through the heart rate values measured
during a submaximal graded exercise test and extrapolating to the age-adjusted maximal heart rate. This VO2 max estimate could be incorrect if:
A. the subjects true maximal heart rate was incorrectly estimated.
B. the subject held onto the treadmill railing during the test.
C. the measurement of treadmill speed and grade were inaccurate.
D. All of the above answers are correct
D. All of the above answers are correct
VO2 max can be estimated by completing a cycle ergometer test to exhaustion. Calculate
the estimated VO2 max from a graded cycle ergometer test given the following information:
Subjects age = 40 years old
Subjects body weight = 72 kilograms
Subjects maximal heart rate = 180 beats/min
Highest work rate achieved on cycle = 1000 kpm
VO2 (ml. min-1) = (1.8 ml.kpm-1 X kpm.min-1 ) + (7ml.kg-1. min-1 X kg body weight)
Using the above information, the estimated VO2 max (ml min-1) would be:
A. 1800
B. 2304
C. 1296
D. VO2 max cannot be calculated from the above information
B. 2304
VO2 max can be estimated by drawing a line through the heart rate values measured
during a submaximal graded exercise test and extrapolating to the age-adjusted maximal heart rate. Which of following factors could contribute to an underestimation of VO2 max using this type of submaximal test?
A. a cool testing environment
B. the subject held onto the treadmill railing during the test
C. a hot and humid testing environment
D. All of the above answers are correct
C. a hot and humid testing environment
A plateau in VO2 is always necessary to insure that a true VO2 max was measured.
False
In general, the overall risk of severe cardiovascular complications or death during a
symptom limited graded exercise test is 1/10,000.
False
The Physical Activity Readiness Questionnaire can be used to estimate VO2 max in a
diverse population.
False
The double product provides an estimate of the work load and oxygen demand of the
heart during exercise.
True
The formula, 250-age, provides an estimate of maximal heart rate in adults
False
One standard error describes where 68% of the estimates are compared to the true value.
True
The risk of cardiac complications during exercise is
A) directly related to the degree of pre-existing cardiac disease.
B) higher in women compared to men.
C) independent of the presence of heart disease.
D) None of these answers is correct.
A) directly related to the degree of pre-existing cardiac disease.
Epidemiological studies confirm that regular physical activity
A) reduces the risk of developing coronary heart disease.
B) lowers the risk of all-cause mortality.
C) reduces the risk of heart disease in both smokers and hypertensive individuals.
D) All of these answers are correct.
D) All of these answers are correct.