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Pharm Remediation > Exam 3- Diabetic Meds > Flashcards

Exam 3- Diabetic Meds Flashcards

1
Q

Metformin/Glucophage

A

Biguanides

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2
Q

Chlorpropamide/Diabinese

A

Sulfonylurea (1st gen)

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3
Q

Tolbutamide/Orinase

A

Sulfonylurea (1st gen)

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4
Q

Glipizide/Glucotrol

A

Sulfonylurea (2nd gen)

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5
Q

Glyburide/Micronase, Diabeta

A

Sulfonylurea (2nd gen)

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6
Q

Glimepiride/Amaryl

A

Sulfonylurea (2nd gen)

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7
Q

Nateglinide/Starlix

A

Meglitinides

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8
Q

Repaglinide/Prandin

A

Meglitinides

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9
Q

Rosiglitazone/Avandia

A

Thiazolidinediones (Glitazones)

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10
Q

Pioglitazone/ACTOS

A

Thiazolidinediones (Glitazones)

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11
Q

Troglitazone/Rezulin

A

Thiazolidinediones (Glitazones) (LETHAL SE)

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12
Q

Acarbose/Precose

A

Alpha-glucosidase inhibitors

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13
Q

Miglitol/Glyset

A

Alpha-glucosidase inhibitors

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14
Q

Sitagliptin/Januvia

A

Dipeptidyl peptidase-4 (DPP-4) inhibitors

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15
Q

Pramlinitide/Smylin

A

Aylin Agonist Analog (Injectable)

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16
Q

Exenatide/Byetta

A

Incretin mimetics (Injectable)

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17
Q

1 Dec liver production of glucose #2 increase insulin sensitivity in the periphery

A

Biguanide (Metformin/Glucophage)

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18
Q

Increase insulin production in the pancreas (secretagogues); bind ATP sensitive K+ channels in beta cells = inc insulin release

A

Sulfonylurea (Glipizide/Glucotrol); Meglitinides (Nateglinide/Starlix)

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19
Q

dec peripheral insulin resistance in skeletal m., fat cells, and liver cells by affecting gene expression of PPAR gamma #2 dec liver production of glucose

A

Thiazolidinediones (TZDs) / Glitazones (Rosiglitazone/Avandia)

20
Q

Interferes with carbohydrate absorption at the GI Brush border

A

Alpha-glucosidase inhibitors (Acarbose/Precose)

21
Q

Diminish the inactivation of GLP-1 and GIP, which serves to increase the secretion of insulin and suppress release of glucagon.

A

Dipeptidyl peptidase-4 (DPP-4) inhibitors

22
Q

Slow gastric emptying and suppress glucagon production

A

Aylin agonist analogs (Pramlintide/Symlin)

23
Q

Enhance glucose-dependent insulin secretion and suppress increased glucagon secretion and also slow gastric emptying (mimics Glucagon-like peptide 1)

A

Incretin mimetics (Exenatide/Byetta)

24
Q

Do not give to people with sulfa allergies

A

Sulfonylureas: Chlorpropamide/Diabinese, Tolbutamide/Orinase, Glipizide/Glucotrol, Glyburide/Micronase, Diabeta, Glimepiride/Amaryl

25
B12 def
Biguanide (Metformin/Glucophage)
26
Lactic acidosis, esp in ppl with renal impairment
Biguanide (Metformin/Glucophage)
27
weight loss
Biguanide (Metformin/Glucophage)
28
weight gain
Sulfonylureas (Glipizide/Glucotrol)
29
Ineffective after 5-10 years
Sulfonylureas (Glipizide/Glucotrol)
30
Med induced hypoglycemia
Sulfonylureas (Glipizide/Glucotrol) and Meglitinides (Nateglinide/Starlix)
31
Do not use with Sulfonylureas
Meglitinides (Nateglinide/Starlix)
32
Rapid absorption, rapid clearance
Meglitinides (Nateglinide/Starlix)
33
Takes 6-14 wks for full effects
Glitazones (TZDs) (Rosiglitazone/Avandia)
34
CHF
Glitazones (TZDs) (Rosiglitazone/Avandia)
35
Only ACTOS with insulin
Glitazones (TZDs) (Rosiglitazone/Avandia)
36
Liver function tests
Glitazones (TZDs) (Rosiglitazone/Avandia)
37
Inc bone fractures
Glitazones (TZDs) (Rosiglitazone/Avandia)
38
Fatal hepatic failure (rare)
Alpha-Glucosidase Inhibitors (Acarbose/precose)
39
If hypoglycemia, use glucose not sucrose
Alpha-Glucosidase Inhibitors (Acarbose/precose)
40
C/I with intestinal dz
Alpha-Glucosidase Inhibitors (Acarbose/precose)
41
Inc risk for pancreatitis
Dipeptidyl peptidase-4 (DPP-4) Inhibitors (Sitagliptin/Januvia)
42
Ok with Metformin, TZDs, Sulfonylureas but NO INSULIN
Dipeptidyl peptidase-4 (DPP-4) Inhibitors (Sitagliptin/Januvia)
43
First approved injectable since insulin
Aylin Agonist Analogs (Pramlintide/Symlin)
44
Synthetic version of amylin (produced with insulin in beta cells)
Aylin Agonist Analogs (Pramlintide/Symlin)
45
Synthetic exendin-4
Incretin mimetics (Exenatide/Byetta)
46
Gila monster spit
Incretin mimetics (Exenatide/Byetta)
47
Used for both Types 1 and 2 DM
Incretin mimetics (Exenatide/Byetta); Aylin Agonist Analogs (Pramlintide/Symlin)

Pharm Remediation (2 decks)

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