Exam 3 Ch. 6 Flashcards
Virus
- Infectious agent w/ simple acellular organization
- No metabolism
- Reproduce only w/in living host cell
- Size 10-400 nm
- Infect animals, plants, fungi, Archea, bacteria
Virology
Study of viruses & other acellular agents
Viruses have no ___
Metabolism
Nucleocapsid
Protein coat + nucleic acid
___ ____ encodes for protein coat
Nucleic acid
Capsid
- Protective protein coat
- Aids in transfer of Nucleic Acid b/w host cells
- Sub unit is capsomer which self assembles
Spikes
Proteins projecting from envelope often used for attachment or release from host cell, some are enzymes
Enveloped virus
Virus w/ a membrane surrounding nucleocapsid
Non-enveloped/ Naked Virus
No envelope!
Virion
Complete virus particle
Bacteriophage
Virus that infects bacteria
Plus/positive strand RNA
RNA genome identical to mRNA
Minus/ negative strand RNA/ DNA
Genome complementary to mRNA
Steps of Viral Multiplication
- Adsorption
- Entry into host cell
- Synthesis
- Assembly
- Release
Adsorption
Receptors on host cell bind to molecules on surface of vision
Entry into host cell
Fusion w/ host cell membrane or by endocytosis or injection of nucleic acid
Synthesis
Production of virus parts by host cell
____ ____ usually take over host cell
Early proteins
____ ____ usually responsible for capsid protein production, self assembly & release
Late proteins
Assembly
Put together vision particles either in nucleus or cytoplasm
Release
Budding or lysis of host cell
Virulent phage
Immediately takes over host cell followed by release from host cell by lysis
Temperate phage
Can either immediately take over & Lyse host cell or can remain in host cell w/out destroying it
Lytic
Take over host cell & lyse
Lysogenic
Phage DNA integrates into host cell chromosome & waits till induction occurs where phage DNA is triggered to come out by stress & then takes over host cell
Lysogeny
Process of bacterial cell being infected by temperate phage & copying the phage every generation
Archeal viruses can be either
Virulent or temperate
Cytocidal effect
Results in cell death, lysis
Cytopathic effects
Damage to host cell caused by viral replication/ synthesis/release like budding, viral inclusions, enlargement of cell, fusion of cells
Oncogenic viruses
Viruses that cause cancer often by inactivating tumor-suppressor genes normally in host cell
Plaques
Form when virus lyses host cells
Viroids
- Naked circular ssRNA
2. Use host cell DNA-dependent RNA polymerase to maked RNA copies
Virusoids
- Satellite
- Closed circular ssRNAs
- Have genes
Prion
Proteinaceous infectious particle
Misfolded protein
Causes normal proteins to Misfold