Exam 3 Ch 22

Question 1

What are stem cells defined by?

Answer 1

Their ability to self-renew and produce differentiated cells

Question 2

Multipotent

Answer 2

Can become multiple types of differentiated cells

Question 3

Unipotent

Answer 3

Can become one type of differentiated cell

Question 4

What do Paneth cell secrete and why?

Answer 4

Wnt and to keep the crypt stem cells in a proliferative state

Question 5

Satellite cells

Answer 5

Specialized myoblasts that reside as “stem cells” for skeletal muscle cells

Question 6

What does a common lymphoid progenitor cell give rise to?

Answer 6

T cells
B cells
Nk cells

Question 7

What does the common myeloid progenitor give rise to?

Answer 7

Macrophage and dendritic
Neutrophil, eosinophil, basophil
Mast cell
Megakaryocytes and platelets
Erythrocyte

Question 8

What does Ephrin-Eph signaling do?

Answer 8

Drives segregation of the different gut cell types

Question 9

What are the three defining properties of stem cells?

Answer 9

1. They are NOT terminally differentiated
2. They can divide without limit
3. Each daughter cell has a choice to remain stemy or terminally differentiate

Question 10

Planarian regeneration

Answer 10

-Grow in size when food is abundant
-Shrink in size when food is scarce
-Can regenerate from a single neoblast

Question 11

Newt regeneration

Answer 11

Form a limb bud and the cells in the bud re-enter the cell cycle and de-differentiate
Then they proliferate and re-differentiate

Question 12

What are the 4 factors needed for fibroblasts to be reprogrammed into iPS cells

Answer 12

OSKM
Oct4
Sox2
Kif4
Myc

Question 13

What is G418 for?

Answer 13

It is to kill off any cells that do not express the resistance gene which is transcribed if the cell has been reprogrammed.