Exam 3 - Caffeine/Cannabinoids

Question 1

How long does it take for caffeine to absorb from the GI tract and where does absorption mostly occur?

Answer 1

30-60 minutes

Begins in stomach but mostly takes place in small intestine

Question 2

What is the half-life of caffeine?

Answer 2

4 hours

Question 3

What is the acute caffeine effect?

Answer 3

Increased blood pressure & respiration rate, higher water excretion, stimulation of catecholamine release from adrenal medulla

Question 4

What happens when you mix alcohol with energy drinks?

Answer 4

Less intoxicated, but alcohol psychomotor effects are still present. You are “wide awake drunk”

Question 5

Caffeine effects

Answer 5

Low doses: enhanced vigor and ability to concentrate

High doses: tension and anxiety

Question 6

Caffeine mechanisms of action at low doses

Answer 6

Blocks A1 and A2A receptors for adenosine (induces drowsiness/sleep)

Question 7

Caffeine mechanisms of action at high doses

Answer 7

Blocks GABA receptors and stimulates release of Ca2+