Exam 3: 9-29 Lecture 1 Flashcards
Which arteries provide blood flow to the brain
2 internal carotids
2 vertebral arteries
What areas do the external carotids provide arterial circulation
Side of the head, the jaw, and side of the face
What artery provides circulation to the top of the head and the forehead
Internal carotid
Why is it useful to assess blood flow patterns on the forehead
This helps assess the function of internal carotids since they are responsible for perfusion of this area
Why do cuts to the forehead bleed profusely
They are perfused by a protective area of circulation, the internal carotids.
What is the normal range of Brain blood flow
750-900mL/min
What percent of CO is delivered to the brain
15%
How are the nutrients that reach the brain dispersed amongst the grey and white matter
80% grey matter (less efficient/less myelin)
20% white matter
What is the top energy consumer in the brain
Electrophysiology
What does electrophysiology involve
Running Na/K pump, allowing ions in and out, pumping ions out.
What does Auto regulation of blood brain flow ensure
It ensures the brain blood flow is maintained when we have fluctuations in arterial blood pressure.
Auto regulation: how do the blood vessels in the brain respond to low systemic blood pressure
The brain blood vessels relax to maintain constant/normal flow
How do we calculate spinal perfusion pressure and what is the normal level
Spinal perfusion pressure is:
Diastolic aortic pressure -CSF pressure
The normal diastolic pressure is 100 and CSF 10. Normal spinal perfusion pressure is 90.
What is the LLA (lower limit of auto regulation in regards to MAP
65-70mm/Hg
What is the ULA (Upper limit of auto regulation) in regards to MAP
Approximately 150mm/Hg
*(MAP of 150 often achievable with exercise)
Why is there a limit on auto regulation
At some point you run out of the ability to dilate/constrict the brain blood vessels
Auto regulation: how do the blood vessels in the brain respond to elevated systemic blood pressure
As MAP increases the blood vessels of the brain constrict or increase vascular tone.
In thinking about ULA why is over perfusion bad
A little over perfusion is okay. A lot of over perfusion can lead to subarachnoid hemorrhages and blood vessel damage.
Can the Upper limit auto regulation adapt and change its set point
Yes. The blood vessels will harden, they can also squeeze tighter due to having more muscle.
Auto regulation:
How does ischemic stroke/MI affect someone with chronic hypertension
Someone with chronic hypertension may adapt a higher ULA and therefore a higher LLA. If the blood pressure dips due to these factors, the normal MAP of 65 may actually be lower than the LLA and the pt may not have the ability to offer collateral circulation.