Exam 3 Flashcards
Describe the physical properties to infections
- mucous ( put it everywhere) it has lysozymes[microbial agent] that enables the breakdown of certain microbial compounds such as breaking up peptidoglycan layers
- tight junctions (to help protect the body) tight junctions are full of glycoprotein and adhesions that help lock the cells into place so that they cannot be separated and bacteria cannot get through and in between the cells
- SALT-also known as skin-associated lymphoid tissue- extra lymphoid support (infection control in the skin) ex: Langerhans(hangs out in the cell all the time)
- GAULT- also known as gut-associated lymphoid tissue-ex: peyers patches, peyers patches are like little pockets that have extra micro-folds.
- CFTR- also known as the cystic fibrosis transmembrane regulator - it is a chloride channel embedded in the epithelial tissue of the lungs that helps to modulate chloride ions going in and out which helps hydrate the mucous
Describe the chemical barriers to infections
- ph (make the stomach extremely acidic so that if anything bad gets in there it will be killed)
- temperature (make the temperature higher than room temperature) ex: constant body temp
- salt (make the outside of the skin super salty)
- oxygen
Know the different antimicrobials
lysosomes-help break up the mag and limp of peptidoglycan
peroxidases-use catalysts to break up hydrogen peroxide and they create reactive oxygen species which can be a targeted attack against the pathogens
definisms-have proteins around 30 to 40 amino acids long so they really take advantage of electrobiochemistry
Signal barriers to infections
All humans should have
1. specific glycoproteins (CD47)
2. Membrane protein called Major Histocompatibility Complex 1 - this is used in a blue person cell
MHC2 is used against a pathogen
What are histamines related to
inflammatTion
Describe lineages and specific features of leukocytes
White blood cells=leukocytes
WBC types:
-Neutrophil(PMN) neutrophil extracellular trap(most abundant leukocyte)*goes and attacks things like cilia
-Eosinophil- release ‘vasoactive’ agents to effect permeability of blood vessels. Eosinophils are made up of tiny granules that are highly acidic (they stain with dye called eosin) granules contain basoactive agents which can affect blood volume
-monocyte- only one nucleus- are able to leave and enter the tissues (extravastation) they differentiate in phagocytes. Monocytes can actually leave places. Monocytes are phagocytes (They can differentiate and usually live in the blood but they can extravasate)
-Lymphocyte- B or T cell ( T and B cells are derived from the same lymphnoid progenitor) Lymphocytes work between the innate and adaptive immune system derived from a lymphnoid progenitor cell
Where do T cells mature
Thymus
Where do B cells mature
Bone marrow
Where do B and T cells originate
Bone Marrow
Describe the process and 5 symptoms of inflammations
- 5 symptoms
-WRAPS
Warmth
Swelling
Altered Function
Pain
Swelling
Process: The splinter pushes skin level resonant floor like staphylococcus aureus deeper into the skin, once it gets deep into the skin, it is considered a pathogen which wreaks havoc. Phagocytotic cells, like macrophages, the launger hans cells, come in and bind to the staphyloccus aureus cells using toll-like receptors and eventually release alarm signals called cytokinesis
How do toll-like receptors know these are pathogens?
MAMPS (microbe associated molecular patterns) ex:LPS, flagellin, then more phagocytotic cells enter different tissues to help out (extravasation)
Give an example of a basic inflammatory response
Infection via splinter-> Resident macrophages engulf pathogens and release cytokinesis-> vasoactive factors and cytokinesis help deliver additional phagocytes-> some cytokinesis initiate healing as pathogens are destroyed
compliment system explained
The compliment system is a part of the immune system that enhances the ability of antibodies and phagocytotic cells to clear microbes and damage cells from an organism, promote inflammation, and attack the pathogens cell membrane
The Renin-angiotensin system (RAS)
- hormone system that regulates blood pressure
- involves ACE2 (angiotensin converting enzyme 2)
What binds to the ACE receptor?
SARS-COV-2
SARS-COV-2 binds to the ACE receptor (hostamino-terminal lobe) with its S protein (carboxy-terminal domain)
true
Coronavirus is a positive sense single stranded RNA
true
What are the four structual proteins of the corona virus?
Membrane(coat)
Envelope(coat)
Nucleoplasmid(inside)
Spike(coat)
Steps of lung infection within SARS-COV-2
- S protein binds to ACE2 receptor
- enters via proteolytic cleavage and fuses with host membrane
- can immediately begin to create proteins
- The negative strand can be used within an RNA-dependent polymerase
- N proteins bind RNA, M,E,S proteins and get inside of host ER
What do new viruses use to undergo exocytosis out of the cell with clathrin-coated residue?
Golgibodies
How does SARS coV continue to fight?
- Inactivating host ribosomes (nsp1)
- modifying host mRNA to make them unreadable
Basic immunity: The body fights back
Dendritic cells process pathogen and present pieces of its called antigens to t cells, these are also called antigen presenting cells