Exam 3 Flashcards
Bipolar I Disorder
Most severe form
Highest mortality rate
At least 1 manic episode
Bipolar II Disorder
At least 1 hypomanic episode
At least 1 major depressive episode
Cyclothymic Disorder
Alternate with symptoms of mild to moderate depression for at least 2 years
Rapid cycling possible
Epidemiology of Bipolar Disorder
Up to 21% of patients with major depression may actually have undiagnosed bipolar disorder
Bipolar I–more common in males
Bipolar II–more common in females
Cyclothymia–usually begins in adolescence or early adulthood
Risk Factors for Bipolar Disorder
Biological factors: genetic, neurobiological, neuroendocrine (hypothyroidism)
Psychological factors
Environmental factors
Assessment for Bipolar Disorder
Mood
Behavior
Thought processes and speech patterns
Cognitive functioning (decreased attention span, distracted easily)
Speech patterns (pressured speech, circumstantial speech, tangential speech, loose associations, flight of ideas, clang associations)
Thought content (grandiose delusions, persecutory delusions)
Self-Assessment for Bipolar Disorder
Manic patient (manipulative, demanding, splitting)
Staff member actions (frequent staff meetings to deal with patient behaviors and staff response, set limits consistently)
Assessment Guidelines for Bipolar Disorder
Danger to self or others Need for protection from uninhibited behaviors Need for hospitalization Medical status Coexisting medical conditions Family's understanding
Planning for Bipolar Disorder
Medical stabilization
Maintaining safety
Nursing care (managing medications, decreasing physical activity, increasing food and fluid intake, ensuring sleep)
Planning for Acute Manic Phase
Medical stabilization
Maintaining safety
In-hospital nursing care
Seclusion, restraint, or ECT may be considered
Implementation for Depressive Episodes
Hospitalization for harmful thoughts
Medication concerns about bringing on a manic phase
Implementation for Manic Episodes
Hospitalization for acute mania
Communicating strategies and challenges
Lithium Carbonate
Mood stabilizer; decreased mania
Therapeutic level: 0.8-1.4
Maintenance blood level: 0.4-1.3
Toxic blood level: 1.5 and above
Takes 10-21 days to get levels stabilized
Give with meals, drink adequate fluids, monitor for weight gain, check renal and thyroid function before giving and monitor those levels throughout due to nephrotoxicity/thyroid toxicity
Contraindications: renal disease, thyroid disorders, brain injury
Lithium Toxicity
- 5-2.0: mental confusion/sedation, poor coordination/coarse tremors, GI distress
- 0-2.5: tinnitus/blurred vision/ataxia, slurred speech/seizures/polyuria, hypotension
Level > 2.5: coma, death
Anticonvulsant Mood Stabilizers
Valproate (Depakote)
Carbamazepine (Tegretol)
Lamotrigine (Lamictal)
Other Treatments for Bipolar
ECT Teamwork and safety Seclusion protocol Support groups Health teaching and health promotion
Persistent Depressive Disorder
Formerly known as dysthymia
Low-level depressive feelings through most of each day, for the majority of days
Two or more of the following: decreased appetite, overeating, insomnia or hypersomnia, low energy, poor self-esteem, difficulty thinking, hopelessness
Premenstrual Dysphoric Disorders
Symptom cluster in last week prior to onset of a woman’s period; include mood swings, irritability, depression, anxiety, feeling overwhelmed, difficulty concentrating
Symptoms decrease significantly or disappear with the onset of menstruation
Major Depressive Disorder
Five or more of the following in a 2 week period: weight loss, appetite changes, sleep disturbances, fatigue, worthlessness or guilt, loss of ability to concentrate, recurrent thoughts of death
PLUS depressed mood or loss of interest or pleasure (anhedonia)
Persistent for 2 weeks to 6 months
Lasts more than 2 years
Recurrent episodes common
Epidemiology of Depression
Leading cause of disability in the US
Comorbidities include schizophrenia, personality disorders, eating disorders
Etiology of Depression
Biological Factors: genetic, biochemical, alterations in hormonal regulation, inflammatory process
Psychological factors: cognitive theory, learned helplessness
Assessment of Depression
Depressed mood and anhedonia Anergia Anxiety Psychomotor agitation or retardation Vegetative sides Chronic pain
Depression Recovery Model
Focus on patient’s strengths
Treatment goals mutually developed
Based on patient’s personal needs and values
Planning geared towards patient’s phase of depression, particular symptoms, personal goals
Phases of Depression
Acute Phase (6-12 weeks)
Continuation Phase (4-9 months)
Maintenance Phase (1 year or more)
How to Choose an Antidepressant
Symptom profile of the patient Side-effect profile Ease of administration History of past response Safety and medical considerations
Antidepressants
SSRIs (first-line therapy, rare risk of serotonin syndrome)
SNRIs
Tricyclic Antidepressants (anticholinergic adverse reactions)
MAOIs (effective for unconventional depression)
Other Treatments for Depression
ECT
TMS
Vagus nerve stimulation
Deep brain stimulation
Light therapy
St. John’s Wort
Exercise
Electroconvulsive Therapy
The most effective depression treatment; also used for psychotic illnesses
Used for lengthy depression, delusional depression, schizophrenia with catatonia
Transcranial Magnetic Stimulation
Noninvasive
Uses MRI-strength magnetic pulses to stimulate focal areas of the cerebral cortex
Presence of metal is only contraindication
Adverse Reactions to TMS
Headache and lightheadedness
No neurological deficits or memory problems, seizures rarely, scalp tingling, discomfort
Vagus Nerve Stimulation
Originally used to treat epilepsy
Decreases seizures and improves mood
Electrical stimulation boosts the level of neurotransmitters
Side Effects of Vagus Nerve Stimulation
Voice alteration
Neck pain, cough, paresthesia, dyspnea