Exam 3 Flashcards
Name the system
- transports fluids throughout the body
- function to transfer essential materials btw external environment and internal organs
- carries oxygen, nutrients, and waste to and from cells
CIRCULATORY SYSTEM
-consist of 2 systems : Cardiovascular and lymphatic systems
There are 2 types of systems in the circulatory system. Name the system respectively
- collects fluid from tissue spaces and returns it to venous circulation
- consist of heart and blood vessels (arteries, capillaries, veins)
- LYMPHATIC SYSTEM
- CARDIOVASCULAR SYSTEM
Describe the pathway of blood flow to and from the heart
- How many valves (from what to what)
- What are the 2 types of circulation (what is the flow)?
RIGHT ATRIUM - Right Ventricle - Pulmonary arteries - LUNGS - lung capillary beds - pulmonary veins - left atrium - left ventricle - systemic arteries - systemic capillary beds - systemic veins - RIGHT ATRIUM
**4 valves RA to RV (tricuspid valve) RV to pulmonary arteries (pulmonary valve) LA to LV (mitral valve) LV to systemic arteries (Aortic valve)
Name the 2 types of circulation respectively
-pumps LOW OXYGEN blood from the RV to the LUNGS (through pulmonary arteries), returns oxygen-rich blood to the left atrium of the heart via pulmonary veins
-pumps OXYGEN RICH blood from LV to all parts of the BODY through the aorta, returns blood to the right atrium of the heart through superior and inferior vena cava and cardiac veins (located on heart)
- Pulmonary circulation
- Systemic circulation
Name the blood vessel types functions respectively
- Arteries
- Veins
- capillaries
What are the exceptions?
- carry OXYGEN-RICH blood under relatively HIGH PRESSURE AWAY from heart to BODY
- exception : PULMONARY ARTERY : carry LOW-OXYGEN blood to LUNGS
- carry blood under LOWER PRESSURE than arteries; return LOW-OXYGEN blood to heart
- *exception: PULMONARY VEINS carry OXYGEN-RICH blood back to HEART
-connect arterial and venous circulation for nutrient, O2 and waster EXCHANGE
Most arteries and veins consist of 3 layers:
Which is which
-inner lining of endothelial cells (single layer) supported by delicate connective tissue; allow DIFFUSION from lumen into vessel wall
- outer connective tissue layer
- middle smooth muscle layer; most variable layer in thickness and amount of elastic fibers; controls arterial gasometer force (constriction and dilation of vessels)
TUNICA INTIMA
TUNICA ADVENTITIA
TUNICA MEDIA
There are 3 types of blood vessels; arteries, veins and capillaries. There blood vessels can be further divided into different types.
WHat is the name of the vessel that RECEIVE the INITIAL CARDIAC OUTPUT? How?
These same vessels can maintain a CONSTANT BP, as heart contracts and relax
LARGE/CONDUCTING ELASTIC arteries
- They have many layers of elastic fibers in the TUNICA MEDIA to allow expansion and recoil during the cardiac cycle.
- This helps maintain a constant flow of blood, minimizing changes in blood pressure as the heart contracts and relaxes
E.g Aorta, arteries that originate off ARCH of area (left subclavian, left common carotid, brachiocephalic trunk) and pulmonary trunk
There are 3 types of blood vessels; arteries, veins and capillaries. There blood vessels can be further divided into different types.
What is the name of the vessel that are composed primarily of the smooth muscle in the tunica media. This allows vessels to DECREASE in diameter (VASOCONSTRICT) and regulate blood flow to different parts of the body
MEDIUM/Distributing MUSCULAR Arteries
-E.g Most of the named arteries including FEMORAL/Thigh and BRACHIAL/arm
- **There are 3 types of artery :
- Large/conducting elastic artery
- medium/distributing muscular arteries
- small arteries and arterioles
There are 3 types of blood vessels; arteries, veins and capillaries. There blood vessels can be further divided into different types.
1) What has narrow lumina and THICK muscular walls?
2) What helps control the filling of capillary beds and regulate the arterial pressure in the vascular system?
1) Small arteries and arterioles
2) Smooth muscle walls of arterioles
E.g not named or identified during dissection, arterioles can only be observed under high magnification
- **There are 3 types of artery :
- Large/conducting elastic artery
- medium/distributing muscular arteries
- small arteries and arterioles
There are 3 types of blood vessels; arteries, veins and capillaries. There blood vessels can be further divided into different types.
- What are the smallest unnamed veins that drain capillaries.
- These join to form SMALL VEINS that empty into larger veins and unite to form what?
- VENULES
- VENOUS PLEXUS
E.g venules are not named or identified during dissection and can only be observed under MAGNIFICATION. The Dorsal VENOUS ARCH of the foot is an example of a larger venous plexus
- *There are 3 types of veins
- Venues
- Medium veins
- Large veins
There are 3 types of blood vessels; arteries, veins and capillaries. There blood vessels can be further divided into different types.
Name the vein type
- drain venous plexus and accompany medium arteries
- contain small amounts of smooth muscle
- thickest layer is TUNICA ADVERTITIA
What does this vein have special and function?
MEDIUM VEINS
**have VENOUS VALVES - passive flaps that permit blood to flow toward the heart but not in reverse direction (The valves help flow against gravity)
E.g named superficial veins of upper and lower limbs (cephalon and basilica of upper limb and great and small saphenous of lower limb)
There are 3 types of blood vessels; arteries, veins and capillaries. There blood vessels can be further divided into different types.
Name the structure and function of LARGE VEINS
- contain smooth muscle
- A well developed tunica adventitia
E.g superior vena cava, inferior vena cava, portal vein
Distinguishing features of veins from arteries
1) Which have thin walls? Thick wall?
2) Which have large luminal diameter?
3) Which pulsate? Spurt when severed?
4) Which accompany the other?
5) Which have valves? Why?
6) Which can expand? How?
1) Veins have thin walls (especially tunica media)
2) Veins have large luminal diameter
3) Veins do not pulsate or spurt blood when severed
4) Veins tend to occur as multiple vessels that ACCOMPANY v=arteries of the same name The accompany veins (L.venae Comitantes) occur as multiple vessels adjacent to an artery in a common vascular sheath
5) veins have VALVES to prevent backflow of blood
6) Veins contain approximately 80% of blood volume due to their large diameter and ability to EXPAND (arteries don’t have same capacity for expansion)
What are the main differences between arteries and veins
ARTERIES
- Transport blood AWAY from heart
- carry OXYGEN rICH blood (except pulmonary artery - carry low oxygen blood to lungs)
- Have relatively NARROW LUMEN
- Have MORE MUSCLE and elastic tissue (helps hold their shape)
- Transport blood under HIGH PRESSURE
- DO NOT HAVE VALVES (except valves of pulmonary artery and aorta
VEINS
- Transport blood TOWARD the heart
- Carry LOW OXYGEN blood (except for pulmonary veins -carry HIGH OXYGEN BLOOD to heart)
- Have relatively LARGE LUMEN
- Have relatively LESS MUSCLE and elastic tissue
- Transport blood underLOWER pressure
- HAVE VALVES throughout main veins of the body to prevent backflow of blood to body
What happens at capillary beds?
EXCHANGE OF MATERIALS
What micro diameter vessel allow exchange of oxygen and nutrients in tissue spaces.
CAPILLARIES
**They are the smallest vascular channel averaging 50micrometers in length and
8-10 micro meters in diameter(RBC are 7.5micro meter in diameter)
**They are composed of simple endothelial cell tubes
- What are networks of capillaries that connect arterioles and venules called?
- What happens at the arteriole and venule end respectively?
- CAPILLARY BEDS
- At Arteriole end ; hydrostatic PRESSURE forces fluid containing OXYGEN and nutrients out of the blood into the cellular space for exchange
- At VENULE END ; osmotic pressure allows waste and CO2 to be reabsorbed into blood for return to the heart
What are the 3 vessels that do microcirculation?
ARTERIOLES
CAPILLARIES
VENULES
- What are principal vessels?
- Name the 3 main arteries that branch from arch of aorta (carry OXYGEN-RICH blood from LV to rest of body)
-Principal vessels are the MAJOR named vessels of the body
-1) BRACHIOCEPHALIC TRUNK divided into ; a) right subclavian artery (feeds upper limb) and b) right common carotid artery (to head and neck)
2) LEFT COMMON CAROTID ARTERY - supplies head and neck
3) LEFT SUBCLAVIAN ARTERY - supplies upper limb
-
-What are the other principal vessels going to and from the heart and what do they supply
1) superior and fervor vena cave - return low-oxygen blood to right atrium of heart
2) Pulmonary veins - carry oxygen rich blood into left atrium of heart
3) Pulmonary trunk - carry low-oxygen blood from the right ventricle to the lungs
4) Aorta - carries oxygen-rich blood from left ventricle to tissues throughout body
5) abdomina aorta - continuation of aorta into abdomen ; gives branches to abdomina organs, divides into common iliac arteries
6) . Common iliac arteries - divide into external and internal iliac (supplies blood to pelvis and lower limb)
WHat is the name of the venous system that Lin’s 2 capillary beds before returning to the heart
PORTAL VENOUS SYSTEM
*In certain regions, blood passes through two capillary beds before returning to the heart
There are 2 classes of portal venous systems
Name this
- This system drains blood from capillary beds of the digestive tract into the hepatic portal vein, which branches into capillary beds (sinusoids) of the liver
- This allows materials to be metabolized and DETOXIFIED before returning to the heart
HEPATIC PORTAL SYSTEM
-There are 2 classes of portal venous systems
Name this
- This system drains blood from capillary beds at the base of the hypothalamus to a capillary plexus around the anterior pituitary gland
- This allows Neuro secretory hormones from the hypothalamus to leave the lord and stimulate cells o the anterior pituitary gland to induce the release of pituitary hormones
HYPOPHYSEAL PORTAL SYSTEM
**The 2 portal venous systems are Hepatic portal and HYPOPHYSEAL portal system
What is a one-way drainage system for returning excess fluids and cellular debris TO THE BLOODSTREAM
What are the functions of these system
LYMPHATIC SYSTEM
- transport large protein molecules that cannot pas through capillaries
- returns up to 3L of excess fluid from cellular spaces each day
Name the vessel
- network of blind/closed tubes that originate in the cellular spaces of tissue
- occur almost everywhere blood capillaries are found except teeth, bone, bone marrow, and CNS
- lack a basement membrane so tissue fluid, proteins, bacteria and even whole cells enter easily
LYMPHATIC CAPILLARIES
What are the following
1) Network of thin-walled, valve-containing vessels that occur throughout the body
2) clear, yellowish fluid that is transported in lymph vessels
3) Masses of lymphatic tissue that filter lymph on its way to the venous system
4) large collecting vessels that unite to form Right lymphatic duct or thoracic duct
1) Lymphatic vessels
2) Lymph
3) Lymph nodes
4) Lymphatic trunks
Lymphatic trunks are large collecting vessels that unit to form right lymphatic duct or the thoracic duct; both empty into the venous system in the neck at the junction of the internal jugular veins and the subclavian veins.
How do both drain lymph?
RIGHT LYMPHATIC DUCT - drains lymph from the upper right quadrant of the body
-right side of the head, neck, thorax and right upper limb
THORACIC DUCT
-drains lymph from the rest of the body
Begins at CISTERNAE CHYLI (large collecting sac that merge lymphatic trunks draining the lower half of the body)
-The thoracic duct ascends into and through the thorax and joins the venous system at the LEFT VENOUS ANGLE, the junction of the left internal jugular vein and left subclavian vein
Name the clinical problem
1) The most common acquired disease of the arteries that is characterized by thickening and loss of elasticity of arterial walls
2) build up of fat and cholesterol in arterial walls
3) clot formed in a blood vessel or in a chamber of the heart that DOES NOT MOVE to another part of the body (it remains in the place of origin)
4) Blood clot that detaches from place of origin and travels to the blood stream
1) Arteriosclerosis
2) Atherosclerosis (common form of arteriosclerosis)
3) Thrombus
4) Embolus
Name the clinical problem
5) obstruction of a blood vessel due to an embolus
6) Area of ischemic necrosis due to TOTAL occlusion of an artery
7) PARTIAL occlusion or narrowing of an artery associated with tissue damage
8) develops if muscle tonus/firmness of arteriole smooth muscles is above normal
9) Abnormally swollen and dilated veins usually occurring in the legs. Walls of veins lose their elasticity and damaged valves allow blood to pool in the veins rather than ascending to the heart
10) swelling of tissue due to excess amount of interstitial fluid. Lymphatic system prevents this accumulation of fluid under normal circumstance
5) Embolism
6) Infarct
7) Stenosis
8) Hypertension (Arteriole smooth muscle control the filling of capillary beds and regulate arterial pressure in the vascular system)
9) varicose veins
10) Edema
Name the clinical problem
11) Regions where blood passes directly from arterial to venous sides of circulation without passing through capillaries
12) communications between arteries that supply regions of the body. These communications can occu between multiple branches of a main artery, or btw series of smaller vessels that supply a tissue in addition to its main blood supply
13) DO NOT ANASTOMOSES with adjacent arteries. Arterial occlusion result in TISSUE NECROSIS
11) Arteriovenous anastomoses (AV shunts)- found in regions of skin (esp fingers) for temperature regulation. Also found in the GUT and are open except during digestion
12) Arterial anastomoses - communication provide COLLATERAL CIRCULATION that is important for maintaining blood supply to a region in the case of a blockage e.g occur around the major joints ; shoulder, elbow, wrist, knee and ankle
13) End Arteries - blockage of an end artery interrupts blood flow to the organ or organ segment it supplies (i.e retina). Functional end arteries supply regions of the brain, liver, kidneys and spleen. Vital organs supplied by end arteries usually develop TISSUE NECROSIS after arterial occlusion (e.g retinal artery blockage leads to blindness)
1) What is the joint between the femur and tibia called?
2) What is the sesamoid bone anterior to knee joint?
3) What is on the posterior side of knee?
4) What forms he 2 joints of the ankle?
1) KNEE
2) PATELLA/Knee cap
3) Popliteal region
4) -One between tibia, fibula and talus
- another between talus and other bones of foot
How does the orientation of upper and lower extremities change with development?
Beginning in 4th week
- UE and LE develop as buds with similar structure
- arms and legs similar in structure with differences in FUNCTION
- Both extremities develop as PROJECTIONS from body axis
- Arms and legs initially have same orientation, PERPENDICULAR to SPINAL COLUMN (palms touch, soles touch)
DEVELOPMENT
- UE rotate laterally (palms forward) **THUMB IS LATERAL
- LE rotate medically (soles of feet back and down) **BIG TOE IS MEDIAL
How do dermatomes of lower extremity change through development?
Name the following body parts the nerves innervate L1 L3,L4 L4 S1 S1,S2
1)Spinal nerves are initially in SEGMENTAL BANDS (UE- C3-T2; LE L1-S2) that elongates: in adult lower extremity; reflect rotation
2) L1 - Inguinal ligament L3,L4 - anterior knee (patella) L4 - medial side of foot, BIG TOE (HALLUX in Latin) S1 - lateral side of foot, LITTLE TOE S1,S2 - posterior side of leg and thigh
1) What 2 parts do the inguinal ligament attach to?
2) What makes up the bones of the pelvis
3) What makes up the innominate bone
4) Where do the 3 bones that make up innominate bone join
1) Anterior superior iliac spine (palpable) and Pubic tubercle
2) 2 Innominate bones, sacrum and coccyx
3) Ilium, Ischium and Pubis
4) - all 3 join at acetabulum (vinegar cup -socket for hip joint)
1) What 2 parts do the inguinal ligament attach to?
2) What makes up the bones of the pelvis
3) What makes up the innominate bone
4) Where do the 3 bones that make up innominate bone join
1) Anterior superior iliac spine (palpable) and Pubic tubercle
2) 2 Innominate bones, sacrum and coccyx
3) Ilium, Ischium and Pubis
4) - all 3 join at acetabulum (vinegar cup -socket for hip joint)
1) What is the large opening surrounded by ischium, pubis and what is it covered by?
2) What is the large bony prominence on posterior part of ischium; people SIT on this and can get pressure from prolonged sitting
1) OBTURATOR FORAMEN
- COvered by the OBTURATOR membrane for muscle attachment
2) ISCHIAL TUBEROSITY
1) What is the name of the Ligament that join the sacrum with the ischial spine
2) What is the name of the ligament that join the sacrum to the ischial tuberosity
3) What is the MAIN function of these 2 Ligaments
1) Sacrospinous ligament
2) Sacrotuberous ligament
3) Sacrospinous and Sacrtuberous ligaments PREVENT SACRUM from ROTATING due to weight transmitted down the vertebral column
NAme the part of the femur
1) Which part of femur is subject to FRACTURE?
2) What is the INDENTATION on the head called ? (For ligament of head to femur)
3) What is located LATERALLY below the neck
4) What is located MEDIALLY below the neck?
5) What is the ridge that connects the 2 trochanter on ANTERIOR side?
6) What is the ridge that connects the 2 trochanter on POSTERIOR side?
7) A large ridge along the length of femur on POSTERIOR side; site of insertion of mUSCLES of thigh
8) A bump located SUPERIOR to the medial epicondyle
1) Neck of femur (NARROW REGION)
2) Fovea capitis
3) Greater trochanter
4) Lesser trochanter
5) INTERTROCHANTERIC line
6) Intertrochanteris CREST
7) LINEA ASPERA
8) Adductor tubercle
Name the parts of tibia
1) bumps on anterior side of tibia - for attachment of patella tendon
2) proximal ends of tibia that articulated with femur
3) distal end of tibia
4) oblique ridge on back of tibia
Name the 3 parts of the fibula
1) Tibia tuberosity
2) Medial and lateral CONDYLES
3) Medial malleolus tibia
4) SOLEAL LINE
Fibula
1) Head
2) Neck
3) Lateral malleus fibula
***The lateral malleolus and the medial malleolus forms a joint in between for DORSIFLEXION, PLANTAR FLEXION
What connects superficial veins to deep veins; have valves that only allow flow from SUPERFICIAL TO DEEP, Not DEEP TO SUPERFICIAL
PERFORATING VEINS
**SUPERFICIAL Veins drain toward body or to deep veins and the VALVES in perforating veins prevent backflow
**Incompetent perforating veins lead to VARICOSE VEINS
ILIOPSOAS
- Origin
- Insertion
- Action
- Nerve
Origin - Ilium, Vertebra (T2-L5)
Insertion - Femur
Action - Flex the hip joint
Nerve - Femoral nerve
PECTINEUS Origin -Insertion -Action -Nerve
Origin - Pubis
Insertion - Femur
Action - Flex hip joint
Insertion - Femoral nerve
SARTORIUS
- Origin
- Insertion
- Action
- Nerve
Origin - Ilium (Anterior Superior iliac spine)
Insertion - Tibia
Action - Flex hip Joint, Flex knee
Nerve - Femoral nerve
RECTUS FEMORIS
- Origin
- Insertion
- Action
- Nerve
**What is special about this muscle?
Origin -Ilium (Anterior Inferior Iliac spine)
Insertion - Patella
Action- Flex hip joint, extend the knee
Nerve - Femoral nerve
**It is BIFUNCTIONAL - cross both HIP and KNEE Joints
VASTUS LATERALIS
- Origin
- Insertion
- Action
- Nerve
Origin -Femur
Insertion - Patella
Action - Extend the knee
Nerve - Femoral nerve
VASTUS MEDIALIS
- Origin
- Insertion
- Action
- Nerve
Origin - Femur
Insertion- Patella
Action - Extend knee
Nerve - Femoral nerve
VASTUS INTERMEDIUS
- Origin
- Insertion
- Action
- Nerve
Origin - Femur
Insertion - Patella
Action - Extend the knee
Nerve - Femoral Nerve
What are he quadriceps?
WHat is there insertion?
How do they insert?
Quads- RECTUS femoris, VASTUS lateralis, VASTUS medialis, VASTUS INTERMEDIUS
Insertion - PATELLA
- *Quads insert to patella via QUADRICEPS tendon
- *Patella is linked to the Tibia via Patella tendon
GRACILIS
- Origin
- Insertion
- Action
- Nerve
Origin - Pubis
Insertion -Tibia
Action - ADDUCT hip joint, FLEX knee
Nerve - OBTURATOR Nerve
ADDUCTOR LONGUS
- Origin
- Insertion
- Action
- Nerve
Origin - Pubis
Insertion - FEMUR (linea aspera)
Action- ADDUCT hip joint
Nerve - OBTURATOR
ADDUCTOR BREVIS
- Origin
- Insertion
- Action
- Nerve
Origin - Pubis
Insertion- Femur (linea aspera)
Action - ADDUCT hip joint
Nerve - OBTURATOR nerve
ADDUCTOR MAGNUS (Adductor portion)
- Origin
- Insertion
- Action
- Nerve
Origin - Pubis, Ischium
Insertion - Femur (linea aspera)
Action - ADDUCT Hip joint
Nerve - OBTURATOR nerve
ADDUCTOR MAGNUS (Hamstring portion)
- Origin
- Insertion
- Action
- Nerve
Origin - Ischial tuberosity
Insertion - Femur (Adductor tubercle - Superior to the medial epicondyle)
Action - Extend the hip joint
Nerve - **SCIATIC NERVE (Tibia part)
OBTURATOR EXTERNUS
- Origin
- Insertion
- Action
- Nerve
Origin - OBTURATOR membrane
Insertion - Femur
Action - LATERALLY rotate femur at hip joint
Nerve - OBTURATOR nerve
GLUTEUS MAXIMUS
- Origin
- Insertion
- Action
- Nerve
Origin - Ilium, sacrum, coccyx, sacrotuberous ligament
Insertion - Femur, Iliotibial tract (IT band)
Action - Extend, LATERALLY rotate femur (also keeps legs extended via IT tract/band)
Nerve - Inferior gluteal nerve
**LARGEST EXTENSORS OF THIGH
Used in running, climbing stairs and raising from stooped position
GLUTEUS MEDIUS
- Origin
- Insertion
- Action
- Nerve
Origin - Ilium
Insertion - Femur (Greater trochanter)
Action - ABDUCT and MEDIALLY rotate femur; (support weight when lift opposite leg)
Nerve - Superior gluteal nerve
GLUTEUS MINIMUS
- Origin
- Insertion
- Action
- Nerve
Origin - Ilium
Insertion - Femur (Greater trochanter)
Action - Abduct and medially rotate the femur, (support weight when lift opposite leg)
Nerve - Superior gluteal nerve
TENSOR FASCIA LATA
- Origin
- Insertion
- Action
- Nerve
Origin - Ilium (Anterior superior iliac spine)
Insertion - Iliotibial tract (IT band)
Action - Abduct femur (also keeps leg extended via IT tract)
Nerve - Superior gluteal nerve
PIRIFORMIS ** (LANDMARK)
- Origin
- Insertion
- Action
- Nerve
Origin - Sacrum
Insertion - Femur (Greater trochanter)
Action - LATERALLY rotate femur
Nerve - Nerve to PIRIFORMIS
OBTURATOR INTERNUS
- Origin
- Insertion
- Action
- Nerve
ORIGIN - OBTURATOR membrane
Insertion - Femur (Greater trochanter)
Action - LATERALLY rotate femur
Nerve - Nerve to OBTURATOR internus
SUPERIOR GEMELLUS
- Origin
- Insertion
- Action
- Nerve
Origin - Ischial Spine
Insertion - Femur (Greater trochanter)
Action - LATERALLY rotate femur
Nerve - Nerve to OBTURATOR internus
INFERIOR GEMELLUS
- Origin
- Insertion
- Action
- Nerve
Origin - Ischial tuberosity
Insertion - Femur (Greater trochanter)
Action - LATERALLY rotate the femur
Nerve - Nerve to quadratics femoris
QUADRATUS FEMORIS
- Origin
- Insertion
- Action
- Nerve
Origin - Ischial tuberosity
Insertion - Femur
Action - LATERALLY rotate the femur
Nerve - Nerve to quadratus femoris
SEMIMEMBRANOSUS
- Origin
- Insertion
- Action
- Nerve
ORIGIN - ISCHIAL TUBEROSITY
Insertion - Tibia
Action - Flex knee, Extend Hip joint
Nerve - Tibial part of sciatic nerve
SEMITENDINOSUS
- Origin
- Insertion
- Action
- Nerve
Origin - Ischial tuberosity
Insertion - Tibia
Action - Flex knee, Extend Hip joint
Nerve - Tibial part of sciatic nerve
BICEPS FEMORIS
- Origin
- Insertion
- Action
- Nerve
Origin - Ischial tuberosity (long head), Femur (short head)
Insertion - Tibia
Action - Flex knee, extend Hip joint (LONG HEAD only)
Nerve - Long head: Tibial part of sciatic nerve.
Short head : Common perineal part of sciatic nerve
ADDUCTOR MAGNUS (hamstring part)
- Origin
- Insertion
- Action
- Nerve
Origin - Ischial tuberosity
Insertion - Femur
Action - Extend hip joint
Nerve - Tibial part of sciatic nerve
POPLITEUS
- Origin
- Insertion
- Action
- Nerve
ORIGIN- Femur
Insertion - Tibia
Action - Laterally rotate the femur (unlock knee)
Nerve - Tibial nerve
There are 3 parts of the superficial group of the POSTERIOR LEG : Gastrocnemius, soles and plantaris
GASTROCNEMIUS
- Origin
- Insertion
- Action
- Nerve
Origin - Femur
Insertion - Calcaneous
Action - Plantar flex foot (weak flex knee)
Nerve - Tibial nerve
There are 3 parts of the superficial group of the posterior leg: Gastrocnemius, soleus and plantaris
SOLEUS
- Origin
- Insertion
- Action
- Nerve
Origin - Fibula, Tibia (soleal line)
Insertion - Calcaneus
Action - Plantar flex foot
Nerve - Tibial nerve
There are 3 parts of the superficial group of the posterior leg: Gastrocnemius, soleus, and plantaris.
PLANTARIS
- Origin
- Insertion
- Action
- Nerve
Origin - Femur
Insertion - Calcaneus
Action - Plantar flex foot
Nerve - Tibial nerve
There are 3 parts of the Deep group of the posterior leg: Flexor hallucis longus, flexor digitorum longus, Tibialis Posterior
FLEXOR HALLUCIS LONGUS
- Origin
- Insertion
- Action
- Nerve
Origin - Fibula
Insertion - Distal phalanx of BIG TOE
Action - Plantar flex BIG toes, Plantar flex foot
Nerve - Tibial nerve
There are 3 parts of the Deep group of the posterior leg: Flexor hallucis longus, flexor digitorum longus, Tibialis Posterior
FLEXOR DIGITORUM LONGUS
- Origin
- Insertion
- Action
- Nerve
Origin - Tibia
Insertion - Distal phalanges of lateral FOUR TOES
Action - Plantar flex lateral FOUR TOES, plantar flex foot
Nerve - Tibial nerve
There are 3 parts of the Deep group of the posterior leg: Flexor hallucis longus, flexor digitorum longus, Tibialis Posterior
TIBIALIS POSTERIOR
- Origin
- Insertion
- Action
- Nerve
Origin - Tibia, Fibula, Interosseous Membrane
Insertion - Navicular bone, cuneiform, cuboid, metatarsals 2-4
Action - Plantar flexes foot, Inverts foot
Nerve - Tibial nerve
what are the 4 principles/stages of development ?
1) DIFFERENTIATION - single fertilized egg produce different cell types
2) MORPHOGENESIS - The different cell types are then organized into tissues
3) GROWTH - Cell division
4) MATURATION - fully formed organs continue to develop functionally (even continues after birth)
How does a single fertilized egg differentiate i.e produce different cell types?
HINTs
What characteristics make it possible
Same or different genome?
Activation or restriction of genes? Which genes?
-All have same genome
-restriction of genes that are active in different cell types
-INDUCTION
A) Paracrine factors ; signal transduction pathways - growth factors, receptors, kinase cascades
B) Positional information ; cell-cell interactions
A single cell can be differentiates into different cell types which the help of several factors. When these cells differentiate, how can they be organized into tissues? What is the process called?
HINT
2 WAYS OF organization into tissues
MORPHOGENESIS
1) Migration
2) Apoptosis
How do cells/tissues grow?
By CELL DIVISION
GIve a brief summary/breakdown of the timeline through out gestation
HINT
Just the weeks classification and summary of events
WEEKS 1-3
- Fertilization through gastrulation
- Primary germ layers (ectoderm, mesoderm, endoderm)
WEEKS 3-8
- Embryonic period
- Organogenesis ;differentiation of the 3 germ layers (cardiac, nervous, skeletal system, eye, ear, limb buds, face, GI tract, long bud, genitalia)
WEEKS 9-38
- Fetal period
- Maturation of tissues and organs
In order for cells to grow, they must divide. These cell divisions lead to distinction between inside and outside of the cell. What is this ability of cells to make this fake decision called? What are the distinctions?
When does this face decision begin?
EARLY FATE DECISIONS (fake decisions)
Inside cells (ICM -inner cell mass) - form EMBRYO Outside cells (Trophoblast) - form part of PLACENTA
**Beings with COMPACTION of BLASTOMERES at 8 cell stage
What are. The 2 early. Fate decisions
What Does fate decision. Mean?
What does the fate decision ultimately lead to?
1) 2 early fate decisions
A) Joining adjacent cells : fertilized egg - blastocyst - differentiate to ICM (will form embryo) and trophoblast (will form part of placenta)
B) Determines whether ICM cells will form EPIBLAST (form amnion and body of embryo) or HYPOBLAST (form wall of primitive and secondary yolk sac)
2) Fate decision means that the cells become more restricted as to which cell types their progeny will become. Some genes inactivated in some cells while others remain activated
3) Fate decisions lead to formation of 3 germ layers (mesoderm, ectoderm and endoderm) by the ICM
ICM - epiblast - primitive ECTODERM - embryonic ECTODERM
ICM - epiblast - primitive ECTODERM - primitive streak -embryonic ENDODERM
ICM - epiblast - primitive ECTODERM - primitive streak - embryonic MESODERM
ICM - epiblast - primitive ECTODERM - primitive streak - extraembryonic MESDODERM
ICM - hypobast - extraembryonic ENDODERM - YOLK SAC
Trophoblast - Cytotrophoblast - Syncytiotrophoblast
Match the following with their appropriate primary germ layers:
1) Nervous system, skin-EPIDERMIS (hair, glands), cornea and lens
2) Muscles, bones, cartilage, skin- DERMIS, heart, blood vessels, blood cells, KIDNEY, gonads and reproductive tract
3) GI TRACT EPITHELIUM, liver, pancreas, pharynx (NECK), thyroid and parathyroid gland, respiratory tract epithelium (LUNGS), BLADDER
4) Gametes (spermatogonia and oogonia) - migrate to somatic part of gonads
1) ECTODERM
2) MESODERM
3) ENDODERM
4) GERM CELLS
WEEK 1 of early development is from fertilization to Implantation. Name the daily steps
Day 1 - Fertilization (zygote contain 1 set of chromosome from each parent)
Day 2 - 2 cells
Day 3 - Morula
Day 4 - Early blastocyst
Day 5 - Late blastocyst
Day 6 - BEGINNING of implantation
Day 7 - INVASION of ENDOMETRIUM (embryo is ready to implant to uterus)
*** fertilized egg - blastocyst- TROPHOBLAST and ICM
WHat happens in day 1 of week 1?
** What must happen for Implantation to occur of day 7?
FERTILIZATION
- creates a new diploid individual (male and female pronuclei)
- Determines SEX of individual
- Takes place in AMPULLA of OVIDUCT (Fallopian tube)
- Oocyte completes meiosis division
- Sperm DNA must decondense
- 2 pronuclei replicate DNA before first cell division
*** For Implantation to occur, blastocyst must break out of zona pellucid a
WHAT Is the goal of Week 2 ?
How
GOAL : Development of Placenta and BILAMINAR Embryo
- Embryo fully embedded in uterine wall
- Establishment of placental circulation
- Formation of first germ layers
- Formation of extraembryonic membranes and cavities
**Trophoblast - cytotrophoblast
BILAMINAR EMBRYO
ICM - HYPOBLAST (forms extraembryonic tissues) and EPIBLAST (forms all tissues of the embryo and amnion)
2 cavities
- Epiblast - separate to 2 layers to form amniotic cavity (top layer - amnion, lower layer - embryo)
- Cells from by HYPOBLAST line the trophoblast - form primitive yolk sac or extracoelomic cavity
What are the results of the Week 2 ?
1) 2 layer embryo
- Epiblast is primitive ECTODERM (3 germ layers)
- Hypoblast is primitive ENDODERM (yolk sac)
2) Cavities
- Amniotic membrane forms from epiblast creates amniotic cavity
- Yolk sac lined with hypoblast and spinachnic extraembryonic mesoderm
What are the events in Week 3
GASTRULATION
- process leads to development of the 3 primitive germ layers (embryonic ectoderm, endoderm and mesoderm)
- cell migration and differentiation converts BILAMINAR disc to TRILAMINAR disc
- Begins with the formation of primitive groove
- establishment of body axes (movement of cells and elongation of the embryonic disc establishes BODY AXES)
What happens EARLY in week 3?
- the primitive streak begins to appear in the CAUDAL HALF of the BILAMINAR DISC (Anterior end is the primitive node)
- Epiblast cells migrate LATERALLY and ANTERIORLY through the primitive streak
WHat is the precursor to the creation of the 3 germ layers in week 3?
-Invagination of EPIBALST into the streak (primitive ectoderm) creates the 3 germ layers (ectoderm, mesoderm, endoderm)
- some replace the hypoblast to form embryonic ENDODERM
- others moving between the epiblast and hypoblast create the embryonic MESODERM
- remaining epiblast cells form the ECTODERM
In week 3, how is Notochord formed and what does it differentiate into?
Epiblast - Mesoderm - Notochord - SPINE
- The ANTERIOR end of the primitive streak is the primitive node (HENSON’s NODE)
- Mesodermal cells anterior to the node form a solid cord in the midline called the NOTOCHORD
In week 3, the Notochord is formed from the mesodermal cells of the epiblast,
* name 3 roles of the notochord?
- signals from the NOTOCHORD induce the overlying ECTODERM to become NERVOUS😬 TISSUE
- signals some of the MESODERMAL cells to become vertebral bodies of the SPINE (nucleus PULPOSUS)
- Forms nucleus PULPOSUS of the vertebral disc
**egg - blastocyst - ICM - Epibast - mesoderm - Notochord - Spine (nucleus PULPOSUS of vertebral disc)
In Week 3, what happens with time to the notochord and primitive streak?
WHat happens to the primitive streak remnant? What is this called?
-With time, the notochord extends anteriorly (gets longer) while the primitive STREAK gets SHORTER
- The remnant of the primitive streak is called SACROCOCCYGEAL TERATOMA
- *These are generally bending tumors containing tissues derived from all 3 germ layers
- *Mostly found in FEMALES
Name the following from week 3 of development
1) SITE of future ORAL CAVITY (contain only ECTODERM and ENDODERM)
2) Contributes to structures in the forebrain and oral cavity (only MESODERM)
3) SITE of FUTURE ANUS (only ECTODERM and ENDODERM
1) Oropharyngeal membrane
2) Prechordal plate (prechordal mesoderm)
3) Cloacal membrane
What happens in weeks 3-8?
-ORGANOGENESIS (differentiation of the 3 germ layers - ectoderm, mesoderm and endoderm)
ECTODERM - nervous system, neural crease walls, skin
MESODERM - paraxial, intermediate, lateral plate, extraembryonic mesoderm)
ENDODERM - epithelial lining of GI tract, lungs, urethra, bladder, parenchyma of thyroid and parathyroid hormone, liver, pancreas, stroma of tonsils and thymus, parts of ear
Between weeks 3-8, the 3 germ layers which were originally formed in week 1-3 get differentiated in a process called ORGANOGENESIS.
What are the derivatives of ECTODERM?
What problems can result?
1) Neural TUBE - form central and peripheral NERVOUS SYSTEM
2) Neural crest
- cells at the crest of neural fold form neural crest cells
- variety of structures in the HEAD
- ganglia
- Adrenal medulla
- Melanocytes
3) Surface ectoderm
- form epidermis and appendages of the SKIN
- glands, hair, nails
- mammary and pituitary glands
- tooth enamel
**Neural tube defects (Anencephaly, Spinal bifid - can both be prevented by folic acid)
What is neurulation?
WHen does it occur? Week period and day ?
BASICALLY notochord signal ectoderm to form neural plate
- Ectoderm above the notochord and prechordal plate forms the NEURAL PLATE beginning at DAY 19
- Signals from the notochord induces the overlying ECTODERM to form the NEUROECTODERM of the NEURAL PLATE
- neuroectoderm begins to fold into a TUBE
**Ectoderm from notochord and prechordal plate - neural plate - neuroectoderm - neural tube
On day 19, neurulation occurs where ectoderm above the notochord join with prechordal plate to form neural plate, neural plate further differentiate into neural ectoderm to form neural tube.
How do theses neural stuff separate out?
1) Neural fold closes into a tube (begins in the future CERVICAL region at somite 5- fusion proceeds CRANIALLY and CAUDALLY)
2) Cells at the boundary between neural ectoderm and surface ectoderm will become Neural CREST cells (These crest cells separate from the neural tube and migrate to from parts of the PNS)
3) Surface ectoderm - cover the neural tube and rest of embryo and form the EPIDERMIS
How does the neural tube close i.e what are the last regions to close?
What day is it completely closed?
What will happen if neural tube don’t close completely?
What are tx/prevention?
1) ANTERIOR and POSTERIOR neuropore are the LAST regions to close
2) Neural tube is completely closed by DAY 28
3) NEURAL TUBE DEFECTS
A) Anencephaly - FATAL - failure to properly close the neural tube at the CRANIAL end
B) Spinal bifida - failure to close the neural tube from the CERVICAL region to the CAUDAL end
4) FOLIC ACID can prevent neural tube defects before and during pregnancy
What do the cells at the crest of the fold form?
What does this differentiate into?
1) NEURAL CREST CELLS
2) Neural crest cells migrate to other areas to form specific structures
- Dorsal root ganglion
- Sympathetic ganglion
- Developing suprarenal gland (epinephrine, norepinephrine/ flight or fight)
- preaortic ganglion
- enteric ganglia
NAME the following fates of the Mesoderm
1) CRANIAL end of node and LATERAL region of primitive streak
2) Midstreak
3) More caudal, splits into 2 layers - parietal/somatic and splanchnic/visceral
4) Most CAUDAL
1) Paraxial mesoderm (PM)
2) Intermediate mesoderm (IM)
3) Lateral plate mesoderm (lpm)
4) Extraembryonic mesoderm (eem)
WHat are the 2 parts of lateral plate mesoderm and what germ layer are each close to respectively?
1) Parietal/somatic layer - close to ECTODERM
2) Visceral/splancnic - close to ENDODERM
What part of the mesoderm organize into paired SOMITES adjacent to the neural tube and notochord? And form the AXIAL SKELETON, associated muscle and DERMIS of skin?
**How do the somites increase in number? Cranial to caudal or caudal to cranial?
PARAXIAL MESODERM
- Development begins at the CRANIAL end and somites increase in number CAUDALLY
- *somites increase in number 2-3 a day
***Paraxial mesoderm - somites - axial skeleton/muscle/dermis
In week 1-3 fertilization leads to gastrulation (form 3 germ layers)
In weeks 3-8 - differentiation of germ layers
Ectoderm - epidermis, nervous tissue, neural tube
Mesoderm - paraxial mesoderm - somites - axial skeleton/muscle/dermis?
How do these somite cells differentiate to form above 3
Cells from Somites form :
1) DERMATOME - Dermis
2) MYOTOME - Muscle
3) SCLEROTOME - tendons/cartilage/bone/vertebra
In week 1-3 fertilization leads to gastrulation (form 3 germ layers)
In weeks 3-8 - differentiation of germ layers
Ectoderm - epidermis, nervous tissue, neural tube
**Mesoderm - Intermediate mesoderm
Where are the IM found?
What do they form?
- IM found between PARAXIAL and LATERAL plate mesoderm)
- forms UROGENITAL structures (parts of urinary system and somatic parts of gonad)
**GERM CELLS
-PRIMORDIAL germ cells arise from EPIBLAST
(In caudal part)
-Migrate through primitive streak to YOLK SAC
-eventually migrate to genital ridge
In week 1-3 fertilization leads to gastrulation (form 3 germ layers)
In weeks 3-8 - differentiation of germ layers
Ectoderm - epidermis, nervous tissue, neural tube
**Mesoderm - Lateral mesoderm - parietal/somatic and visceral/splanchnic
What do these parts form?
SOMATIC/PARIETAL
- forms BODY WALL
- DERMIS of body wall
- Bones and CT of limbs and sternum
- Lining of intraembryonic cavity
VISCERAL/SPLANCHNIC
-Covers organs (forms MESOTHELIUM)
In mesoderm,
1) What does lateral folding of the embryonic disc create?
2) How are blood cells/islands formed? Where and when?
3) What is main site of hematopoises from 2-7 months?
4) What is responsible for hematopoiesis after 7 months?
1) Between weeks 3-4, lateral folding of embryonic disc creates the INTRAEBRYONIC CAVITY and closes the wall of the gut
2) Blood islands formed by HAMANGIOBLASTS appear in the Mesoderm of wall of YOLK SAC beginning in week 3
3) LIVER
4) STEM cells in BONE MARROW
In mesoderm,
1) How are blood vessels formed?
2) What is the common precursor for both blood cells and vessels?
3) What are the 2 mechanisms?
1) Blood vessels are formed from mesoderm cells that differentiate into hemangioblasts
2) HEMANGIOBLASTS
3)
- Vasculogenesis : blood vessels/endothelial cells derived from BLOOD ISLANDS
-Angiogenesis : Sprouting of vessels from existing vessels
Name the condition of mesoderm
- Excessive growth of blood vessels
- Most common tumor in infants
- Can cause secondary problems
What is the tx?
HEMANGIOMAS
-Tx with prednisone/surgery if bad
In mesoderm, As the neural tube is forming, what forms alongside?
What region?
**Formation of the heart
-folding of the cranial region due to growth of the neural tube brings the developing heart into the THORACIC REGION
In mesoderm,
1) How does head and tail fold?
2) What does this result in ?
3) What will it form?
4) what will it pull?
1) Head and tail fold VENTRALLY
2) Ventral fold in combination with LATERAL folding CLOSES the body wall
3) Forms gut and yolk sac becomes VITELLINE DUCT
4) Pulls amnion completely around embryo
What are the derivatives of Endoderm?
- Epithelial lining of the GI tract, lung, urethra, bladder
- Parenchyma of thyroid, parathyroid, liver and pancreas
- Stroma of tonsils and thymus, parts of ear
1) What happens at the end of week 8?
2) what is the period from 3 months to birth called? What happens here?
1) All organ systems are DEVELOPED, but need further growth and maturation
2) FETAL PERIOD
- growth in length and weight
How do you calculate gestational age under the following timelines:
1) Pregnancy
2) Embryonic period
3) Fetal period
1) Pregnancy
- 266 days or 38 weeks after fertilization
- 280 days or 40 weeks after the first day of LMP
2) Embryonic period (week 3-8)
- SOMITE number
3) FETAL period (week 8-38)
- crown to rump length
- crown to heel length
- other : head circumference and femur length
In the 3 time periods, when is the risk of birth defects highest? Lowest ?
When is the first prenatal visit?
-HIGHEST risk of birth defects in EMBRYONIC PERIOD (Week 3-8)
**First prenatal visit is WEEK 8
- LOWEST RISK (Week 1-3 and Weeks 8-38)
- Fetal period is week 8-38