Exam 3

Question 1

Which NOAC causes increased GI bleeding?

Answer 1

apixaban

Question 2

Which NOAC has an antidote and what is it called?

Answer 2

dabigatran, antidote is idarucizumab

Question 3

What are the investigational NOAC antidotes?

Answer 3

andexanet alfa

ciraparantag

Question 4

Which investigational NOAC is factor Xa specific and which one is universal?

Answer 4

Xa: andexanet alfa
universal: ciraparantag

Question 5

Which NOACs do not use starter injectable anticoag?

Answer 5

rivaroxaban

apixaban

Question 6

What are the inhibitors of NOAC DDI?

Answer 6

dronaderone
ketoconazole
diltiazem

Question 7

What are the inducers of NOAC DDI?

Answer 7

rifampin

St. John’s wort

Question 8

Which NOAC is heavily reliant on renal CL?

Answer 8

dabigatran, but all are renally metabbed to some extent

Question 9

Which NOAC is dialyzable?

Answer 9

dabigatran

Question 10

Which NOAC needs to be taken with food?

Answer 10

rivaroxaban

Question 11

Which NOACs require an injectable lead-in anticoag?

Answer 11

dabigatran

edoxaban

Question 12

Which NOACs are indicated for orthopedic surgery?

Answer 12

rivaroxaban

apixaban

Question 13

What is the dosing of apixaban in prevention of thrombus in atrial fibrillation?

Answer 13

5 mg BID

IF two or more of following 2.5 mg BID: ≥ 80 years, ≤ 60 kg, CrCL ≥ 1.5 mg/dL, on strong dual inhibitors of 3A4 or p-gp

Question 14

What is the dosing of dabigatran in prevention of thrombus in atrial fibrillation withOUT p-gp inhibitors?

Answer 14

CrCL > 30 mL/min: 150 mg BID

CrCL 15-30 mL/min 75 mg BID

Question 15

What is the dosing of dabigatran in prevention of VTE in a-fib WITH p-gp inhibitors?

Answer 15

CrCL 30-50 mL/min: 75 mg BID

CrCL

Question 16

What is the dosing of edoxaban in prevention of VTE in a-fib?

Answer 16

CrCL 50-95 mL/min: 60 mg QD
CrCL 15-50 mL/min: 30 mg QD
CrCL > 95 mL/min: contraindicated

Question 17

What is the dosing of rivaroxaban in prevention of VTE in a-fib at CrCL ≥ 50 mL/min?

Answer 17

20 mg QD with evening meal

Question 18

What is the dosing of rivaroxaban in prevention of VTE in a-fib at CrCL 15-50 mL/min?

Answer 18

15 mg QD with evening meal

Question 19

What is the dosing of rivaroxaban in prevention of VTE in a-fib at CrCL

Answer 19

not recommended

Question 20

What is the dosing of apixaban in VTE prevention in hip or knee replacement?

Answer 20

2.5 mg BID

Question 21

What is the dosing of apixaban in treatment of VTE?

Answer 21

10 mg BID x7D then 5 mg BID

after 6 months: 2.5 mg BID

Question 22

What is the dosing of dabigatran in treatment of VTE withOUT p-gp inhibitors at CrCL > 30 mL/min?

Answer 22

150 mg BID after 5-10 days of parenteral anticoag

Answer 23

not recommended