Exam 3 Flashcards
monosodium urate crystals
hyperuricemia (purine metabolism = uric acid)
95% underexcreters (mostly decrease renal function)
stage I - asymptomatic, no treatment needed
stage II - acute, severe attack of 1 joint
stage III - after 10+ years of acute attacks, chronic swelling and tophi
rapid onset pain, redness, warmth
PODAGRA - MTP joint of great toe
often recurrent
Gout
Gout diagnostics and treatment
radiography = joint erosion arthrocentesis = (-) BIREFRINGENT
Treatment: analgesia, NSAIDs (indomethacin or Naproxen)
Colchicine (diarrhea side effect)
glucocorticoids if can’t take NSAID or colchicine - sugar can rise in DM pts
*Urate-Lowering Therapy - goal to maintain serum uric acid of 6.0 or less
Probenecid - uricosuric agent
–> underexcreters only and avoid in pt with ASA (aspirin) use or nephrolithiasis (kidney stones)
Allopurinol (Zyloprim) and Febuxostat (Uloric) - xanthine oxidase inhibitors
Agent of Choice - Allopurinol - good for both over and underexcreters
Prophylaxis with colchicine or NSAID first, then initiate urate-lowering therapy
–> may precipitate an acute attack
calcium pyrophosphate dihydrate (CPP) crystals
comorbidities
acute, typically mono-articular - 50% knees
may mimic RA, OA or septic arthritis
self-limited
Pseudogout (chondrocalcinosis or CPPD deposition disease)
Pseudogout diagnostics and treatment
synovial fluid aspiration - (+) BIREFRINGENT
Treatment: NSAIDs or cholchicine glucocorticoids (oral or systemic) if above doesn't work remove crystals via joint aspiration ice joint immobilization
considered chronic if 3+ attacks in a year
autoantibodies to nuclear antigens (inflammatory autoimmune disorder)
multi system disease
more common in blacks and females
fever, fatigue, weight change malar rash photosensitivity symmetric nonerosive arthritis Raynaud's phenomenon (white - blue - red episodic vasospastic disease) serositis (cardiopulmonary inflammation)
Systemic Lupus Erythematous (SLE)
Systemic Lupus Erythematous (SLE) diagnostics and treatment
ANA –> anti-dsDNA and anti-Sm subtypes
C3 and C4 - complement system
CBC, ESR (erythrocyte sedimentation rate/sed rate)
imaging if needed
Treatment: sun protection, diet, exercise, etc.
NSAIDs and rest for mild sxs
cytotoxic/immunosuppressive agents (ie. methotrexate) for severe sxs
systemic corticosteroids
antimalarials - hydroxychloroquine (Plaquenil) with ophthalmology f/u
drug-induced SLE (HIP drugs among others - hydralazine, isoniazid, procainamide)
–> (+) antihistone antibody
chronic, systemic autoimmune disorder
diminished exocrine gland function (salivary & lacrimal)
more common in females
common association with SLE, RA and systemic sclerosis
SICCA complex - dry eyes, dry mouth --> keratoconjunctivitis, xerostomia arthritis/arthralgia parotid gland enlargement fatigue Raynaud's
Sjogren Syndrome (SS)
Sjogren Syndrome (SS) diagnostics and treatment
ANA –> anti-Ro.SSA and anti-La/SSB subtypes
Schemer’s test - tear production
salivary gland biopsy
Treatment: regular f/u with dentist and ophthalmologist
dry eyes –> artificial tears, cyclosporine drops
xerostomia - biotene OTC (saliva substitute)
steroids
rare, chronic autoimmune disorder diffuse FIBROSIS of skin and internal organs skin appears taut and shiny 2 forms: limited (80%) diffuse (20%) more common in females
arthralgia/arthritis
pericarditis
renal and pulmonary HTN
limited: CREST syndrome calcinosis cutis (calcification of subQ tissues) Raynaud's esophageal dysmotility sclerodactyly (puffy hands) telangiectasia
diffuse (worse prognosis):
rapid development of symmetric skin thickening on trunk and proximal extremities
more likely to have significant internal organ damage
Systemic Sclerosis (Scleroderma)
Systemic Sclerosis (Scleroderma) diagnostics and treatment
ANA –> anti-SCL-70
proteinuria (renal involvement)
Treatment: symptomatic and supportive
Raynaud’s - Nifedipine (Ca2+ channel blocker)
Esophageal - H2 blockers, H+ pump inhibitors, small more frequent meals
inflammatory arthritis triggered by antecedent GI/GU infection
HLA-B27 + (85%)
“can’t see, can’t pee, can’t climb a tree”
more common in men (post-GU infection)
acute, asymmetric oligoarthritis - often lower extremities
1-4 weeks post-GI/GU infection
diarrhea (GI) or urethritis (GI - “can’t pee”)
conjunctivitis (“can’t see”)
keratoderma blennorrhagicum on palms and soles
Reactive Arthritis (“Reiter’s Syndrome”)
Reactive Arthritis (“Reiter’s Syndrome”) treatment
NSAIDs - indomethacin
intra-articular/systemic glucocorticoids
methotrexate (MTX) or anti-TNF (cytotoxic/immunosuppressive) if above doesn’t work
sxs resolve 6-12 months
chronic, systemic, inflammatory autoimmune disorder
thickening of synovial membrane = inflammation (synovitis)
–> can lead to carpal tunnel over time
destruction of cartilage and bone
joint deformity and loss of fctn if not treated
gradual onset
symmetric polyarthritis
*morning stiffness for at least 1 hour
distal sites affected early - MCP and PIP joints
phys exam: ulnar deviation of MCP joints Boutonniere deformity (PIP) Swan neck deformity (DIP) - more severe disease tenderness/swelling *rheumatoid nodules = unfavorable sign (elbows)
Rheumatoid Arthritis (RA)
Rheumatoid Arthritis (RA) diagnostics and treatment
radiography - preferred initial --> soft tissue swelling around joint --> periarticular osteopenia (thinning bones around joint) --> narrowing joint space --> subluxation/dislocation --> bone erosion and joint obliteration MRI and U/S to check for synovitis joint aspiration if unsure
Lab: CBC/ESR
rheumatoid factor (RF) –> (+) early in course = more severe
anti-CCP antibodies (newer and more specific)
ANA (non-specific)
Treatment: control synovitis, prevent joint injury, preserve ADLs
NSAIDs + glucocorticoids
DMARDs (disease modifying anti-rheumatic drugs)
–> slows/halts disease progression
–> refer to Rheumatology
ex. methotrexate, sulfasalazine (synthetic)
ex. TNF inhibitors Enbrel, Remicaid, Humira (biologic) - risky
*CVD most common cause of death
degenerative joint/disk disease
risks: age, female, obesity, genetic, general wear/tear
pain exacerbated by activity and relieved by rest
morning stiffness typically resolves in less than 30 min
typically hands, knee, hip, pine
crepitus bony enlargement decreased ROM and malalignment tenderness Bouchard's nodes (PIP) Heberden's nodes (DIP) 1st carpometacarpal joint (CMC) osteophytes effusions pain around hip/groin referred to knee cervical and lumbar spondylosis
Osteoarthritis (OA)
Osteoarthritis (OA) diagnostics and treatment
radiological: joint space narrowing
osteophytes
subchondral sclerosis and cysts
(-) RF and anti-CCP
no joint obliteration like RA
Treatment: pain control
minimize disability and pt education
NSAIDs (ie. diclofenac)
narcotics - sparingly if at all
intra-articular glucocorticoids
–> no more than 2-3 times per year - atrophy to cartilage
surgical = joint replacement or resurfacing
chronic inflammatory rheumatic condition
*association with giant cell (temporal) arteritis
gradual onset symmetric stiffness at least 30min
shoulder pain > hip and neck (proximal regions)
synovitis and bursitis
edema
decreased ROM
“gel” phenomenon = stiffness after periods of rest
Polymyalgia Rheumatica (PMR)
Polymyalgia Rheumatica (PMR) diagnostics and treatment
elevated ESR (>40)
(-) ANA, RF, anti-CCP
imaging - x-ray, MRI, U/S
*general rule of thumb:
male = age/2 = ESR
female = (age + 10)/2 = ESR
Treatment: RAPID RESOLUTION with low dose glucocorticoids (ie. prednisone)
MTX or TNF inhibitors for select pts
PT
NSAIDs
soft tissue pain disorder - muscles, tendons, ligaments
widespread, chronic
women 20-55yo = common complaint
no tissue inflammation
aching stiffness fatigue paresthesia hard time explaining what hurts headaches insomnia superficial pain in 11/18 tender points
Fibromyalgia
Fibromyalgia treatment
cyclobenzaprine - muscle relaxer
antidepressant - amitriptyline, cymbalta (SNRIs)
anticonvulsants - Lyrica, Neurontin (gabapentin)
psych referral
*avoid narcotics - addiction
non-displaced
fragments in anatomic alignment
displaced
fragments no longer in usual alignment
angulated
fragments maligned and angular
bayonetted
distal fragment longitudinally overlaps proximal fragment
distracted
distal fragment separated from proximal fragment by a gap
closed
skin over and near fracture intact
open
skin over and near fracture lacerated or abraded by the injury –> REFER
transverse
perpendicular to shaft of bone
comminuted
2+ fragments of fracture
oblique
angulated fracture line
segmental
type of comminuted fx in which a completely separate segment of bone is bordered by fx lines
spiral
multiplanar and complex fx line (common in ski injuries)
intra-articular
fx line crosses articular cartilage and enters the joint
torus
incomplete buckle fx of one cortex often seen in children
greenstick
incomplete fx with angular deformity seen in children
almost like it bends and one side breaks but the other doesn’t
impaction
one bone hits or “impacts” an adjacent bone
compression
type of impaction fx that occurs in vertebrae resulting in depression of end plates
often in older people with osteoporosis
depression
type of impaction fx that occurs in the knee when the femoral condyle strikes softer tibial plateau
stress (fatigue)
fx in normal bone that has been subjected to repeated or cyclical loads that in and of themselves are not sufficient to cause a fx
stress (insufficiency)
fx in weakened bone that has been subjected to a load insufficient to fx a normal bone
pathologic
fx through bone weaker by tumor, metabolic bone disease or osteoporosis
SITS muscles (SIT = ext rot & ABd, S = int rot)
pain over anterior and lateral aspects of shoulder that radiates to deltoid and progressively worsens
decreased ROM (inability to ABduct above shoulder)
shoulder may catch/click
subacromial tenderness
Drop arm and empty can tests
acute tear = often labral pathology
chronic tear = pain usually worse at night, gradual weakness does NOT improve with analgesics
Rotator Cuff Tear
Rotator Cuff Tear diagnostics and treatment
lidocaine injection test
radiograph - elevation of humeral head 1+cm
*MR ARTHROGRAM (good for labral pathology too)
Treatment: ice and NSAIDs
weighted pendulum stretching with some shoulder immobilization
PT
if persistent, subacromial steroid injection or surgery
*principle cause of rotator cuff tendonitis
subacromial (pinpoint) tenderness
gradual pain in lateral shoulder that radiates to deltoid
normal glenohumeral joint ROM
*preserved strength
Neer’s and Hawkin’s tests (flexion, int rot maneuvers)
Shoulder Impingement Syndrome
Shoulder Impingement Syndrome diagnostics and treatment
radiography - normal in 1st episode pts
MRI useful for chronic sxs
Treatment: ice, NSAIDs, activity modification
*NO arm sling recommended
PT referral with f/u
if persistent, corticosteroid injections or surgery
stiffened glenohumeral joint
secondary to injury, trauma, overuse, sling use, bursitis
may develop adhesions
chronic pain with limited ROM due to mechanical restriction
Apley Scratch test –> comparison is key
ABduction and ext rot
Adhesive Capsulitis (“frozen shoulder”)
Adhesive Capsulitis (“frozen shoulder”) treatment
imaging isn’t helpful
Treatment: PT consult - stretch lining of joint
treat underlying process
complains of bump on shoulder that is worse at bedtime
AC joint swelling, tenderness and possible deformity
pain aggravated by downward traction
Cross-Over test –> pain with passive cross-body ADduction
sprain, partial or complete tear
Acromioclavicular (AC) Injury
Acromioclavicular (AC) Injury grading
Grade I - AC joint intact, point tender SPRAIN without separation, normal radiographs
Grade II - separation of superior and inferior AC ligaments, decreased ROM, instability with stress testing of AC joint, radiographic evidence (PARTIAL TEAR)
Grade III - separation of superior and inferior AC ligaments AND coracoclavicular ligament, severe pain, decreased ROM and instability
radiograph shows inferior margin of distal clavicle at or above superior margin of acromion (COMPLETE TEAR)
Acromioclavicular (AC) Injury treatment
shoulder immobilizer 3-4 weeks for comfort
ice, rest, NSAIDs
corticosteroid injection if not improving
surgical for Grade III (recent studies do not support)
tenderness to palpation over clavicle visual deformity seen decrease ROM apprehension and guarding single AP radiograph of clavicle
70-80% middle 1/3 - typically displaces superiorly
Clavicle Fracture
Clavicle Fracture treatment
sling/swathe or figure 8 harness
analgesics and muscle relaxers
sleep upright
ortho referral for all displace and proximal or distal fxs
–> surgery
inflammation or degeneration of sack-like structure
repetitive movement injury
pain to shoulder with ROM and rest
localized tenderness to palpation
warm, red, fever, malaise
*not often isolated and may cause impingement
Subacromial Bursitis
Subacromial Bursitis treatment
fluid aspiration if suspected sepsis, otherwise imaging provides little benefit
ice and NSAIDs
restriction of overuse
aspiration and corticosteroid injection
pain to anterior shoulder with ABduction and ext rot
popping sensation
weakness
Yergason’s and Speed’s tests
inflammation of long head of biceps tendon as it passes through bicipital groove
Biceps Tendonitis
Biceps Tendonitis treatment
U/S beneficial
NSAIDs and rest
PT
surgery