Exam 3 Flashcards
7 major metabolic functions of the liver?
-Carbohydrate metabolism
-Fat metabolism
-Protein metabolism
-Steroid metbolism
-Detoxification/Filters
-Bile synthesis
-Storage
~Glucose/Vitamins A,D,E, K
_________ conversion of glucose into glycogen.
Glycogenesis
–Hepatitis A–
Transmission?
S&S?
At Risk?
t: contaminated water, food, fecal oral route, food contamination
s&s: mild, “flu” like sx, if are advanced in age or have chronic dx then s/s increase in severity, no jaundice (aniteric), acute onset
R: children, 3rd world countries, healthcare personnel, institutional settings
–Hepatitis B–
Transmission?
S&S?
At Risk?
t: occurs when infected blood or other body fluid enter body of person not immune to virus
s&s: jaundiced, insidious onset, sx may be more severe, or may be asymptomatic, can lead to chronic viral infection
r: young children & all age groups, institutional settings, healthcare personnel, adults that share things
What Labs will be elevated with Hep-B?
-ALT: indicates Liver damage
~Norm:8-20
-AST: Norm: 5-40
-ALP: Norm: 42-128
Hep-B has a complex
________ with 3________.
-Structure
-antigens
~Surface HBsAG
~Core HBsAG
~E antigen HBeAG
–Hepatitis C–
Transmission?
S&S?
At Risk?
t: percutaneously, blood to blood, illicit IV drug sharing, blood products & organ transplants prior to 1992
s&s: leads to chronic liver disease/cirrhosis, most are asymptomatic
r: HIV pts, hemophiliacs, sharing needles, body piercings, tattoos, perinatal transmission, healthcare workers
Which Phase of hepatitis is marked by:
a. Absence of jaundice
b. Lasts 5-7 days
c. N/V, malaise
d. Anorexia, fatigue
e. RUQ pain
f. Irritable
g. Requires rest
-Acute-Anicteric Phase
Which phase of hepatitis is marked by:
a. Jaundice present
b. Dark urine, clay stools
c. As jaundice worsens, child feels better
d. Lasts 4 weeks
e. Labs return to normal may take 1-3mos
-Acute- Icteric Phase
Icteric:__________
Jaundiced
What antieimetic can you give to a hepatitis pt?
Non hepatotoxic drugs like Dramaine
Nutrition for Acute Viral Hepatitis?
- Protein: maintain protein stores & prevent muscle wasting
- High CHO: ensure calorie intake & prevent protein depletion
- Low fat: Lessesns stomach distention
Drug therapy for Hep-C?
- Interferon
- Ribavirin: w/interferon
~SE: anemia, watch CBC. Flu like sx, itching, diarrhea, wt loss, anorexia, cough, insomnia, pruritus, rash, HA, fatigue
4 Types of Cirrhosis?
- Biliary Cirrhosis: gallbladder backs up & causes obstructions, diffuse fibrosis of the liver w/jaundice
- Cardiac Cirrhosis: heart failure & fluid buildup, portal HTN, from long standing R sided HF
- Postnecrotic Cirrhosis: caused by Hep C (10-20%), Hep B (10%), certain drugs & chemicals
- Laennec’s Cirrhosis: Alcohol induced
Esophageal and Gastric _______ are possible complications of what?
- Varices
- Cirrhosis
With Esophageal and Gastric varices, why doesn’t the bleeding stop??
Production of bile is decreased which prevents absorption of fat soluble vitamins (specifically Vit. K), without K pt. lacks clotting factors
_______________: disorder of protein metabolism & excretion, liver can’t covert ammonia to urea, ammonia cross blood-brain barrier & cause neurologic toxic manifestations
-Hepatic encephalopathy
a. Affects function of the brain
b. Elevated ammonia levels
c. Flapping hands (asterixis), fector hepaticus (breath is odd, can’t break down all the food for digestion, glucose, etc)
4 Stages of Encephalopathy?
a. Prodromal: early stg, able to talk, possible agitation, subtle personality changes
b. Impending: disoriented x3, climbing out of bed, etc
c. Stuporous: drowsy, but able to arouse
d. Comatose: only respond to painful stimuli
Treatment of Encephalopathy:?
PO or enema lactulose, decreases protein b/c ammonia is formed when protein is broken down by intestinal flora
Hepatorenal syndrome: ?
- When the volume or pressure of blood flow through the kidney drops, filtering of blood also drops or may not occur at all. Waste products stay in the blood & little or no urine is formed, even though kidney is working.
4 CIWA stages?
Treatment?
- Minor withdrawal: 6-36 hrs
- Seizures: 6-48 hrs
- ETOH Hallucinations: 12-48 hrs
- Delirium Tremors (DTs): 48-96 hrs
Treat w/ Ativan, valium, Librium, thiamine, folic acid
________: a disorder in which there are multiple defects in the coagulation cascade that causes inappropriate clotting within the vascular system throughout the body.
Disseminated Intravascular Coagulation (DIC)
In forming many clots, it depletes or consumes various factors needed for clot formation, eventually leading to bleeding & excessive clot formation
What are the 3 most common cause of DIC?
- Sepsis (Gram Neg)
- Shock
- Liver disease
S&S of DIC depends on what 4 components?
i. Procoagulant Activation: recognition that clots are being formed at increased rate
ii. Fibrinolytic activation: evidence of increase rate of clot dissolution
iii. Consumption of inhibitory factors: evidence that coagulation cascade is overpowering the inhibitory factors
iv. End organ damage or failure: evidence that the coagulation problem is causing problem with organ system(s)