Exam 3 Flashcards

1
Q

DSM criteria for PTSD

A

Symptom duration for at least 1 months posts-trauma

includes re-experiencing (e.g., flashbacks, intrusive thoughts), avoidance (e.g., avoiding reminders of the trauma), negative alterations in cognition and mood (e.g., persistent negative beliefs, emotional numbness), and hyper-arousal (e.g., irritability, difficulty sleeping)

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2
Q

Key symptoms of PTSD

A

dissociation (feeling detached from reality) - derealization & depersonalization

  • flashbacks (reliving the trauma)
  • hyper-arousal (heightened state of alertness)
  • nightmares (disturbing dreams related to trauma)
  • avoidance (avoiding places, people, activities that remind of the trauma)
  • negative thoughts (persistent negative beliefs about oneself or the world)
  • mood changes (e.g., depression, anxiety)
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3
Q

Shattering of schemas

A

Persistent feeling of being unsafe, disrupted beliefs about the world and self, difficulty trusting others, feeling vulnerable and exposed

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4
Q

Biological factors in PTSD

A

Role of cortisol (stress hormone), heritability (genetic predisposition), brain impact of early trauma (e.g., changes in hippocampus, amygdala, prefrontal cortex)

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4
Q

Prevalence rate of PTSD

A

Only about 10% of those who experience trauma develop full PTSD; varies based on type and severity of trauma, individual resilience, and support systems

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5
Q

What are some predictors of PTSD?

A
  1. Genetic vulnerability (explains about 30% of variance in some studies
  2. Neurological vulnerability (link with early trauma history)
  3. Lack of social support
  4. Perceived severity of trauma
  5. Use of physical violence in trauma
  6. DSM co-morbidity (e.g., depression, anxiety, eating disorder)
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6
Q

Adverse Childhood Experiences (ACEs)

A

ACEs increase vulnerability to PTSD; includes abuse (physical, emotional, sexual), neglect (physical, emotional), household dysfunction (e.g., substance abuse, domestic violence, mental illness)

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7
Q

Complex PTSD (c-PTSD)

A

not in DSM, added to ICD-11

  • repeated childhood trauma
  • PTSD symptoms + disordered emotion regulation (difficulty managing emotions), identity (unstable sense of self), relationships (difficulty forming and maintaining relationships)
  • very similar to borderline personality disorder
  • Treatment is way different and takes more time to treat someone with c-PTSD than with PTSD
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8
Q

Treatments of PTSD

A
  1. Medication (antidepressant & antianxiety)
  2. Cognitive-behavioral therapies (graded exposure to traumatic memories, processing trauma & modifying core beliefs)
  3. EMDR (Eye Movement Desensitization & Reprocessing)
    - Theory: something about getting both hemispheres of the brain processing the traumatic event by invoking somatosensory bilateral stimulation by doing exposure and the recall of the trauma. It leads to a deeper type of exposure that allows the exposure to be more effective
    - Trauma has a physical imprint, and EMDR gets the person in touch with how their body is being encoded in their sensory memories
  4. Psychodynamic Therapy
  5. CISD (Critical Incident Stress Debriefing)
    - meeting in a group of strangers who went through traumatic events, everyone is encouraged to share their stories, not helpful if it’s a group of complete strangers. People will open up before they’re ready
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9
Q

Concept Creep for “Trauma” in Pop Culture

A

Many upsetting events are labeled as trauma, but not all meet clinical criteria for genuine trauma; genuine trauma involves threat to life or physical integrity, intense fear, helplessness, or horror

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10
Q

Traumatic repression of memories

A

Scientific evidence does not fully support the concept of traumatic memory repression; memories of trauma are often fragmented and can be influenced by suggestive questioning

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11
Q

Definition of obsession

A

Recurrent, persistent thoughts, urges, or images that are intrusive and unwanted, causing significant anxiety or distress. Common themes include aggression, contamination, sexuality, and harm

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12
Q

Compulsions/Rituals

A

Repetitive behaviors or mental acts performed to reduce anxiety triggered by obsessions

Ex. hand washing, checking, counting, and repeating actions

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13
Q

OCD vs OCPD

A

OCD:
- involves unwanted, distressing obsessions and complusions

OCPD (obsessive-complusive personality disorder) involves a chronic preoccupation with orderliness, perfectionism, and control, often described as having an “anal” personality

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14
Q

Role of Anterior Cingulate Cortex

A

“error detection”

Involved in error detection and emotional regulation. Dsyfunction in this area, along with serotonin imbalances, is linked to OCD

  • CSTC circuit “brain lock”
    - Their attention gets fixated on their obsession, begin to do a ritual to get rid of it, ritual doesn’t work, and there ends up being too much activity in CSTC circuit and keeps the brain hyperfixating
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15
Q

DSM Criteria for OCD

A

Presence of obsessions, compulsions, or both. There must be time-consuming (e.g., more than 1 hour per day) and cause significant distress or impairment in social, occupational, or other important areas of functioning

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16
Q

Risk factors for OCD

A

Heritability (genetic predisposition), head trauma, and strep infections (PANDAS)

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17
Q

Role of CSTC Circuit

A

CSTC circuit regulates information flow to the cortex. In OCD, this circuit gets “stuck” in a loop, leading to repetitive thoughts and behaviors. Serotonin circuits help inhibit this “brain lock” pattern

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18
Q

Treatment for OCD

A
  1. Exposure and Ritual Preventions (ERP) therapy (86% response)
    - ERP involves gradual exposure to feared situations and prevention of compulsive responses
  2. Anafranil (48% response)
  3. SSRI/SNRI (40-50% response rate)
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19
Q

OCD Spectrum Disorders

A

Includes hoarding disorder, trichotillomania (hair-pulling disorder), excoriation disorder (skin-picking disorder), and body dysmorphic disorder

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20
Q

Hoarding disorder vs OCD

A

Hoarding disorder involves ego-syntonic obsessions (consistent with one’s self-image)

OCD involves ego-dystonic obsessions (inconsistent with one’s self-image and causing distress

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21
Q

Ego-syntonic obsessions vs ego-dystonic obsessions

A

Ego-syntonic obsessions - consistent with one’s self-image

ego-dystonic obsessions - inconsistent with one’s self-image and causing distress

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22
Q

Core symptoms of Major Depressive Disorder (MDD)

A

DSM requires 5 or more of the below for multiple times a day ≥ 2 weeks (one of them MUST include symptoms 1 or 2)

  1. Depressed Mood
  2. Loss of interest/pleasure in activities (anhedonia)
  3. Change in sleep (insomnia/hypersomnia)
  4. Change in weight/appetite
  5. Loss of energy
  6. Psychomotor retardation/agitation
  7. Excessive guilt or worthlessness
  8. Concentration difficulty/difficulty making decisions
  9. Suicidality/thoughts of death
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23
Q

Depression Subtypes

A

Severe or Melancholic (motor retardation, anhedonia, diurnal mood variation, cognitive impairment)
- Have all or nearly all 9 DSM core symptoms at a very, very high level of severity
- Diurnal mood variation - mood goes up and down throughout a 24-hr cycle. Wake up very tearful and mood brightens throughout day

Seasonal Onset or Atypical (hypersomnia, weight gain, sluggishness, anxiety)
- December thru February (1/4 people in US)
- vitamin C and D deficiency (D is created in skin when adequately strong UV rays from sun hit our skin)

Psychotic (delusions or hallucinations - only present during depressive episode)

24
Costs of Depression
Depression is the #1 cause of work-related disability worldwide, leading to significant economic and personal costs
25
Heritability and genome-wide association studies (GWAS)
Depression is polygenic, meaning it involves multiple genes. Heritability estimates suggest a genetic contribution of about 40-50%
26
Neurobiology of depression
Sleep architecture: loss of slow-wave sleep, altered REM sleep patterns Left Frontal cortex: reduced activity in this region Neurotransmitter systems: dysregulation of dopamine and serotonin Hormones: imbalances in testosterone, estrogen, allopregnanolone CRH: Corticotropin-releasing hormone regulates the stress response Inflammation: increased inflammatory markers BDNF: involved in neuroplasticity and memory formation
27
High cortisol effects
reduced BDNF cortisol triggers inflammation runaway stress response --> inflammation --> tells brain body is sick --> body shuts down neurotoxicity
28
Beck's cognitive models of depression
Negative/neutral event -----> automatic thoughts ------> depression After some training: Negative/neutral event -----> maladaptive schemas -----> biased processing (logical errors) ------> automatic thoughts -------> depression depression caused by negatively biased thoughts Beck wants us to consider the thoughts that come into our head, use logical thinking, and not believe the automatic thoughts immediately automatic thoughts - "automatic" negative interpretation of events and do not evaluate it logically but instead treat it as the absolute truth Logical errors - give rise to automatic thoughts (all-or-nothing thinking) Schemas - core beliefs, taken as a given - schemas are dormant until activated. Once activated, events are filtered through the scheme. Conformational bias can kick in
29
Ilardi's environmental mutation model
Modern lifestyle factors contribute to depression. Treatments include: 1. light therapy (10,000 lux) - natural sunlight increases BDNF, serotonin & dopamine function 2. aerobic exercise (30 mins, 3x/week) - increases BDNF, serotonin and dopamine function 3. omega-3 EPA (anti-inflammatory/antidepressant) - 1000-2000 mg EPA 4. social connection and belonging 5. sleep (target 7-9 hours) 6. anti-rumination strategies
30
Effectiveness of SSRI/SNRI vs CBT
SSRIs/SNRIs (e.g., Prozac, Effexor) are effective for short-term symptom relief. CBT is effective for both short-term and long-term management, addressing underlying cognitive patterns
31
List off SSRIs
Prozac, Paxil, Zoloft, Celexa, Lexapro
32
List the brand name/generic for the SSRIs
Prozac - Fleoxetine Paxil - Paroxetine Zoloft - Sertraline Celexa - Citalopram Lexapro - Escitalopram
33
List off SNRIs
Effexor, Pristiq, Cymbalta
34
List the brand name/generic for the SNRIs
Effexor - venlafaxine Pristiq - desvenlafaxine Cymbalta - duloxetine
35
Describe Wellbutrin
Bupropion Targets dopamine, can increase pleasure spontaneous orgasm At higher dosage, elevates risk of seizures
36
Describe St. John's Wort
hypericum boosts serotonin signals herbal remedy
37
Describe Psychedelics
Psilocybin, MDMA, ketamine Puts people in a state/trance where their defense is low; dissociation can occur incredibly receptive to positive, corrective information
38
Major symptoms of mania, hypomania, and mixed episode
Mania: Elevated or irritable mood, increased activity or energy, grandiosity, decreased need for sleep, talkativeness, racing thoughts, distractibility, increased goal-directed activity, risky behaviors Hypomania: Similar to mania but less severe, does not cause significant impairment Mixed Episode: Symptoms of both mania and depression occurring nearly every day for at least one week
39
Diagnostic Criteria for Bipolar I, Bipolar II, and "type III Bipolar"
Bipolar I: At least one manic episode, may include hypomanic and depressive episodes Bipolar II: At least one hypomanic episode and one major depressive episode, no full manic episodes “Type III Bipolar” (Bipolar NOS): Symptoms that do not fit the criteria for Bipolar I or II but still cause significant distress or impairment
40
Drug triggers of mania
antidepressants, stimulants, THC (cannabis), binge drinking, steroids
41
Iatrogenic effect of antidepressants in bipolar
Antidepressants can trigger manic episodes in individuals with bipolar disorder, leading to worsening of symptoms
42
Lifetime prevalence of bipolar disorder
~ 4% of the population
43
Suicide risk in bipolar disorder
roughly 3 times higher than in Major Depressive Disorder (MDD)
44
Effects on disability, employment, and life expectancy
Significant impact on disability, reduced employment rates, and decreased life expectancy due to medical comorbidities and suicide risk
45
Creativity and divergent thinking with BPD
Some individuals with bipolar disorder exhibit higher levels of creativity and divergent thinking, particularly during hypomanic episodes
46
Heritability of bipolar disorder
~ 80%, indicating a strong genetic component
47
Excessive amygdala reactivity
Increased intensity of emotional responses, contributing to mood instability
48
Dopamine circuitry in bipolar disorder
involves activation/arousal and goal-directed/reward-based behavior, dysregulation can lead to manic symptoms
49
Frontal cortex/glutamate in bipolar disorder
Mania: increased left frontal cortex activity Depression: increased right frontal cortex activity Glutamate: imbalance in excitatory neurotransmission
50
Triggers of bipolar episodes
Sleep deprivation, major life events, exposure to light
51
Kindling hypothesis
Each mood episode increases the likelihood of future episodes, similar to kindling a fire
52
Rapid cycling and ultra-rapid cycling
Rapid Cycling: Four or more mood episodes per year Ultra-Rapid Cycling: Mood episodes occurring within days or weeks
53
Lithium in BPD
Mood stabilizer commonly used to treat bipolar disorder, effective in reducing manic and depressive episodes
54
what else are used as mood stabilizers?
Other anticonvulsants Lamictal (lamotrigine), Topamax (topiramate), used as mood stabilizers in bipolar disorder
55
Novel antipsychotics
Newer antipsychotic medications used to treat bipolar disorder, no need to learn specific names
56
Lifestyle interventions
Omega-3s (for depression), regular exercise, light/dark therapy (lightbox for depression, amber lenses for mania)
57
Miklowitz’ Family Focused Therapy (FFT)
Therapy involving family members to improve communication and support, cuts relapse risk in half