EXAM 3 Flashcards

1
Q

Chemical digestion

Fats

A

LIPIDS:
Triglycerides are absoped as FATTY ACIDS & MONOGLYCERIDES

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Chemical Digestion

Protiens

A
  • AMINO ACIDS:
    absorped as small peptides and amino acids
  • AA uptake in sodium coupled transporters
  • peptides absorped faster than AA and require PepT1(ogliopeptides)
  • Pepsin activated at low pH levels 1.8-3.0..irreversible inactivated at 7.2
  • Bicarb layer protects mucous lining
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Chemical Digestion

Carbohydrates

A

STARCHES absorped as MONOSACCHARIDES

A-amalyse enzyme starts in mouth..digest starches

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Enzyme Release

Salivary Glands

A

Amylase break down starches
Lipase break down triglycerides

Carbs (Starches) are the only macronutrient that digest in the mouth

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Enzyme Release

Stomach

A

Pepsin breaks down protiens
Lipase breaks down triglycerides

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Enzyme Release

Pancreas

ACTIVE ENZYMES

A

a-amylase & lipase

starches and triglycerides

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Enzyme Release

Intestines

A

Enterokinase (activate trypsin)
Diasaccharides (complex sugars)
Dipeptides (peptides)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Trypsin

A

A protease that ACTIVATES SECRETED XYMOGENS (Lysine & Argenine)
Breaks down peptides to ogliopeptides

Chymotrypsin cleaves to trypsin

Released in pancreas

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Goblet Cells

A

Secrete mucus, deuodnum to ileum

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Stem Cells

A

Repairs cell complex when old cells die

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Endocrines

A

Hormones released in the blood

Gastrin is an example

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Paracrines

A

Act on neighboring cells in the same tissue

Somatostatin and histamine are examples

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Neurocrines

A

Neurotransmitters

That thanksgiving smell makes you hungry!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Hormone

Secretin

A
  1. Released from S-CELLS in DUODENUM
  2. INHIBITS GASTRIC ACID RELEASE
  3. STIMULATE PEPSIN & HCO3- SECRETION

The duodenum pH IS <4.5

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Hormone

Gastrin

A
  1. Secrete gastric acid & growth of mucosa, duodenum, and colon
  2. Antrum and Duodenum
  3. Little (17AA): secrete from G Cells
  4. Big (34AA): secrete from duodenal
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Gastrinoma

A
  • Causes hypergastrinemia
  • Increase parietal cell mass & acid secretion (low pH)
  • peptic ulcer
  • Decrease bile & lipase (causing diarrhea, steatorrhea, hypokalemia)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Hypokalemia

A

Less K+ in the blood due to loss of K+ from diarrhea, vomiting, etc.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Zollinger Ellison Syndrome

A

Gastrin levels increase after injecting secretin due to failure of inhibiting gastrin release

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Hormone

CCK

A
  1. In the DUODENUM & JEJUNUM
  2. Release bile into duodenal
  3. Empty gallbladder
  4. Inhibits gastric emptying
  5. Fatty acids, peptieds, and AA stimulate release

Your stomach wont deliver any more food until the batch is digested, this is what it means for gastric emptying to be paused

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Hormone

GLIP

Secretin family

A
  1. STIMULATES insulin release
  2. INHIBITS gastric acid secretion
  3. Oral glucose, only released when injested…meaning when there is a presence of food in the intestines that needs to be digested
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Hormone

Motilin

A

Stimulates upper GI motility during fasting periods

Released from M-CELLS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Hormones

Somatostatin

In D cells of the corpus

A

1.Inhibits PARIETAL CELL acid secretion (decreasing acid release)
2.STIMULATED by ACID
3.INHIBITED by ACh D-Cells

Paracrine

Inhibits histamine and gastrin release

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Hormones

Histamine

Paracrine

A

Released from ECL cells w/ gastrin & ACh
1. Stimulates acid secretion
2. H2 receptors block acid secretion
3. Hypergastrinemia Acid supression so gastrin remains high

CIMETIDINE & RATITIDINE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

VIP

A
  • Relaxes the smooth muscle in the gut
  • Stimulate fluid secretion and electrolytes
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

GRP/ Bombesin

A

Increase gastric release

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

Enkephalins

A

Increase smooth muscle tone
* Stifness decreases GI motility

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

Myenteric A. Plexux

A

Located in the proximal esophagus to anus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

Submucosal Meissner Plexus

A

Large Intestines Only
* Sensory, local secretion & absorption, and contraction

Nerve plexus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

Ascending cholinergic

A

Ms contraction promels intraluminal distally towards anus
* ACh for contraction
* Peptide YY is located in colon, senses fat and protiesn, slows intestinal emptying (inhibit motility for more nutrient absorption)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

IPAN

A

Inintiate peristalsis and dynamic contraction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

Mast Cells

A
  1. Monitor sensory input from lumen
  2. Respond to foreign antigers chemically (histamine)
  3. Increase gut motility to rid foreign antigers
  4. TnFa can be released immediately
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

Peristalsis

A
  1. __
  2. I. contraction ahead of bolus
  3. continued contraction before bolus
  4. force bolus foward
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

Dysphagia

A
  1. Anestesia: aspiration of stomach contents
  2. Stroke: damage cranial nerves and leads to aspiration
  3. MS Diseases: Polio, Myestenia Gravis, Botulism

Swallowing disorders

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

Gastroenphageal Reflux Disease

A

In the lower esophageal spincter
1. Backwash of acid, pepsin, & bile into esophagus
2. Barret esophagus: tissue replaced by goblet cells, increase cancer risk

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

Gastric Motility

A
  1. Caudad Area: mix food with gastric juice
  2. nitric oxide relaxes orad area (upper stomach)
36
Q

What happens during increased gastric emptying?

A
  1. INCREASED orad tone & DECREASED pylorus tone
  2. force contraction
  3. Empty intestines
37
Q

Acinar cells

A

Secrete Cl- and enzymes
Isotonic
1. Na/K pump moves Na+ basolaterally inward
2. Na/K/Cl cotransporter bring cl- into cell
3. Rise in K+
4. Cl- secretes into lumen
5. Na+ driven into lumen

CCK & ACh increase acinar secretion of Na& Cl

38
Q

Duct cells

A

Secrete bicarb and K+
High mitochondria
pH < 7.4

Secretin

Ouabaine BLOCKS HCO3-
Atrophine BLOCKS ACh and Ca2+

39
Q

Pancreatitis

A

Decrease HCO3-
Leads to dehydration and oily stool (steatorrhea)
Alcohol & Cystic Fibrosis
Failure of the pancreas

40
Q

Stomach

A
  • Functions for food storage and protien digestion
  • Cardia – Located near the gastroesophageal junction, devoid of acid-secreting cells.
    Body (Corpus) – The largest portion, where acid-secreting cells are located.
    Antrum – The distal region that leads to the pylorus, involved in secreting regulatory hormones.
  • Gastric (oxyntic) glands: Secrete digestive substances like acid and pepsinogen.
    Pyloric glands: Primarily secrete regulatory hormones, including gastrin and somatostatin.
  • Superficial epithelial cells and mucous neck cells secrete bicarbonate and mucus, forming an alkaline barrier.
    Parietal cells secrete acid and intrinsic factor, crucial for vitamin B12 absorption.
    Chief cells secrete pepsinogen, which is activated by the acidic environment to break down proteins.
    Endocrine cells release regulatory hormones (gastrin, somatostatin) that help manage digestion.

Cardia, Fundus, Antrum, Cells

41
Q

What is Hirschsprung disease and how is it treated?

A
  • mutations in multiple genes (e.g., endothelin-B receptor) leading to the failure of neural crest cells to migrate caudally
  • Constipation Megacolon Narrowed colon segment (usually in the rectum)
  • Absence of ganglion cells in the submucosal (Meissner’s) and myenteric (Auerbach’s) plexuses.
  • Surgical removal of the aganglionic segment of the colon to restore normal function.
42
Q

What systems are involved in neuroendocrine control of pancreatic secretion?

A

Parasympathetic nervous system: Main regulator during fasting (phase 3)
Cholecystokinin (CCK): Stimulates enzyme secretion during the fed state.
Adrenergic pathways: Can suppress fasting secretion through α-adrenergic tone.

43
Q

What is the relationship between migrating motor complexes (MMCs) and pancreatic secretion?

A

Phase I: Quiescent motility, minimal pancreatic secretion.
Phase II: Increased motility, increased secretion.
Phase III: Maximal motility and peak secretion.
Phase IV: Secretion declines after phase III

44
Q

Telenzepine (M1 antagonist)

A

reduce pancreatic enzyme secretion by more than 85% during phases II and III.

45
Q

What is nonpropulsive segmentation in the colon?

A

Nonpropulsive segmentation is driven by slow-wave activity, resulting in circular muscle contractions that churn the colonic contents.
This movement pushes material toward the cecum (orad direction).
Haustra (the typical segmented appearance) are formed during this process, giving the colon its segmented look.
The primary function is mixing, and it helps with fluid and electrolyte absorption.
Material stays in the proximal large intestine for longer periods during this phase.

46
Q

What is mass peristalsis, and when does it occur?

A

Mass peristalsis is a strong, propulsive contraction that moves colonic contents distally (20 cm or more).
It occurs 1-3 times a day, often triggered by eating.
During mass peristalsis, haustra disappear as the contents are propelled forward, and they reappear afterward.
Mass peristalsis is the primary form of propulsive motility in the colon.

47
Q

What motor activity occurs in the distal colon?

A

n the distal colon, the primary motor activity is nonpropulsive segmentation through annular or segmental contractions.
This is where the final desiccation (water absorption) of colonic contents occurs.
The contents are stored in the distal colon until an occasional mass peristalsis moves them into the rectum.

48
Q

How does the rectum fill, and what role does mass peristalsis play?

A

The rectum remains nearly empty due to nonpropulsive segmentation until mass peristalsis occurs in the distal colon.
Mass peristalsis propels contents into the rectum, triggering rectal filling.
This process facilitates the storage and eventual evacuation of fecal material.

49
Q

Serous secretion vs. Mucus Secretion

A

Serous contains salivary enzymes in a watery base
Mucus provided lubrication to help food move through the esophagus

50
Q

Average daily salivatory secretion

A

1-1.5L of saliva daily

51
Q

Major salivary glands

A

Parotid & Submandibular (majority of production)
Sublingual (mucins/ lubrication)
Buccal (mucous secretions)

52
Q

Kalikrien Function

A

Secreted by all but the buccal glands. Cleaves kininogen to PRODUCE BRADYKININ that increases salivary secretion rate

53
Q

Carb digestion process

A

A-Amylase in saliva (oligosaccharides)
40% digestion occurs in stomach
Pancreatic amylase continues digestion in small intestine
Monosaccharides occur at brush border

54
Q

Brush border disaccharides

A

Lactase: breaks down to glucose and galactose
Maltase: breaks down maltose into glucose
Sucrase-isomaltose: breaks down sucrose into glucose and fructose

55
Q

Monosaccharide Absorption

A

Glucose & Galactose: Absorbed by SGTL1 with Na+
Fructose: GLUT5 facilitated diffusion
Exit via GLUT2 transporter

56
Q

L-Glucose

A

Cannot be absorbed by the body

57
Q

Phlorizin

A

Inhibits SGTL1, reduce blood glucose

58
Q

Fructose

A

Less insulin and leptin results in less appetite suppression
High fructose increases fat production in liver

59
Q

CCK

A

Secreted from duodenum in response to fats

60
Q

PYY

A

Secreted in the ileum and proximal colon, slowing gastric emptying so more nutrients are absorbed

61
Q

Fat Digestion process

A
  1. Emulsification: promote enzyme breakdown
  2. Triglyceride breakdown: duodenum, yields momoacylglycerols and fatty acid
  3. Reassembly: Triacylglycerols reassembled in enterocytes
62
Q

Lipase Enzymes and Breakdown

A
  • Gastric lipase: breaks down 15% fats in stomach
  • Lingual lipase
  • Pancreatic lipase: Yield sn2-monoacylglycerols
  • Cholesterolester hydrolase and others work in duodenum and jejunum to complete lipid hydrolysis

Gastric, lingual, pancreatic lipase cleave at sn3 positions

63
Q

Fatty Acid Absorption

A

Mucus layer, Unstirred water layer, apical membrane enterocytes
Occurs by direct diffusion, membrane incorporation, or fatty acid translocase (FAT/CD36)

64
Q

Exetimbe

Lipid medicine

A

Inhibits cholesterol absorption by blocking brush border protiens

65
Q

Lipitor (atarvastatin)

A

Inhibits cholesterol synthesis by blocking HMG-CoA reductase

66
Q

Chylomicrons

A

Formed from lipolytic products, enter lymphatic circulation, and then bloodstream
largest lipoprotiens
Taken up by liver hepatocytes for breakdown
Long chain fatty acids turn into cylomicrons for transport

67
Q

Bile acid reabsorption

A

Bile acids: secreted into duodenum
Enterohepatic circulation: reabsorbed in distal small intestine and recycled back to liver
Conjugated bile acids: absorbed in the terminal ileum
Unconjugated bile acids: passively absrobed throughout intestine

68
Q

Bile salts

A

Help in digestion and absorption of fats in the small intestine, critical for continued fat digestion

69
Q

Intestine structure

A

Crypts: ion secretion
Surface epithelium: electrolyte absorption
Villi

70
Q

Paneth Cells

A

Sense bacteria in the small intestine
trigger antimicrobal responses to prevent bacteria from penetrating mucosal surface

lysozymes, a-defensisn, c-type lectins, TNF-a

71
Q

Fluid absorption in intestines

A

Small intestine: 75% of 8-9L daily fluids
Large intestine: 2L fluid daily, increases to 4-5L if small intestine decreases absorption

72
Q

Electrolyte movement in the intestines

A

Potassium is absorped in small intestine and secreted in colon
Intestines secrete bicarb
Intestines absorb water, Na+, Cl-

73
Q

Sodium-proton exchanger in small intestine

A

NHE3: apical, Na+ absorption in duodenum and jejunum
NHE1: basolateral, regulate intracellular pH
Alkaline lumen: stimulate Na+ uptake in proximal small intestine in the presence of bicarb

74
Q

Na+ absorption in intestines

A

Na+ absorped through Na/H exchanger
Cl- absorped through HCO3-/Cl- exchanger
Na+ absorption in the distal colon va epithelian Na+ channels

Cl- absorped paracellularly and transcellularly

75
Q

Chloride Bicarb Exchanger

A

Parallel or independent
ileum and proximal colon during interdigestive period

76
Q

K+ Secretion in colon

A

Passive: paracellular by lumen negative voltage
Active: aldosterone and cAMP (increase the BK activity in cells)
Colon HK pump mediates absorption (can be inhibited by ouabaine)

77
Q

Melena (balck stool)

A

Digestion of blood in upper GI bleeding
can also result from iron supplements

78
Q

Maroon Stool

A

Incomplete digestion of blood from center small intestine or proximal colon

79
Q

How does bile duct blockage affect stool color?

A

Prevents bile from reaching intestinal lumen
lack of stercobilin
Clay colored stool

80
Q

Greasy, yellow stool

A

Poor fat digestion and absorption

81
Q

Secretory diarrhea

A

cholera toxin
increase intracellular cAMP, activate chloride channels in the apical membrane causing chloride and water secretion into lumen

82
Q

Osmotic diarrhea

A

Excess osmotically active particles in lumen
retain water leading to diarrhea

83
Q

Rotavirus

A

Caused diarrhea by increasing Ca2+ levels leading to Cl- secretion
damage enterocytes leading to osmotic diarrhea

84
Q

Motility

A

Chime moves too quickly= increased fluid excretion
vagotoy lead to dumping syndrome and diarrhea

85
Q

Cholera toxin

A

10L of fluid loss per day
Oral rehydration solution: treat cholera
Causes increase in intracellular cAMP (prevent G-alpha-S from hydrolyzing GTP)
Cause excess Cl- secretion
* CFTR activity is increased leading to excess water and Na+ in lumen

86
Q

Cystic Fibrosis

A

limit cholera toxin ability to hyperactivate CFTR
CF hererzygotes protect against cholera