Exam 3 Flashcards
fat soluble vs water soluble vitamins
fat: ADEK
water: BC
fortification
process of adding nutrients to foods
added nutrients are generally not food in the foods or are added in much larger amounts
enrichment
adding nutrients back to foods that have lost nutrients due to processing
dietary supplements
cannot replace the benefits of a diet containing a wide variety of foods
vitamins in the mouth
chewing breaks food into small particles, helping to release vitamins
vitamins in the stomach
digestion releases vitamins, some niacin is absorbed
vitamins and the gallbladder
releases bile which emulsifies fat and helps absorb fat-soluble vitamins
vitamins and the pancreas
secretes digestive enzymes that help release vitamins
fat soluble vitamins in the small intestine
incorporated into micelles and absorbed via simple diffusion
inside the mucosal cells, they are packaged in chylomicrons, which enter the lymph
water soluble vitamins in the small intestine
absorbed directly into the blood
many depend on active transport or must bind to specific molecules in the GI tract
bioavailability
- vitamins must be absorbed by the body in order to perform
- fat soluble vitamins require fat
- water soluble may require specific molecules/active transport
some - some vitamins are absorbed in inactive provitamin or vitamin precursor forms that must be converted to active forms by the body
water soluble storage and excretion
easily excreted, except B12
stores can be rapidly depleted, so must be consumed regularly
fat soluble storage and excretion
- stored in the liver and fatty tissue so it takes longer for a deficiency to develop
- increased risk for toxicity
coenzymes
- vitamin combines with chemical group to form functional coenzyme
- functional coenzyme combines with incomplete enzyme to form active enzyme
- active enzyme binds to one or more molecules and accelerates the chemical reaction to form new molecules
- enzyme and coenzyme (vitamin) can be reused or separated
- essential for energy metabolism
is fresh fruit better?
- canned can provide an available, affordable source of nutrients
- fresh can be lower in nutrients due to transport time
- frozen can minimize nutrient loss
thiamin/B1
- assists in energy production, carb metabolism, production of ribose, health of nervous system
- beriberi: deficiency
- wernicke-korsakoff: deficiency in alcoholics
riboflavin
- easily destroyed by heat and light
- important in citric acid cycle and for assisting with absorption of other vitamins
- FAD and FMN are coenzyme forms
- Ariboflavinosis: deficiency
niacin
- can be synthesized from tryptophan
- important in production of energy and metabolism
- two forms: nicotinic acid and nicotinamide
- two active coenzymes: NAD and NAPD
- Pellagra: deficiency; symptoms are dermatitis, diarrhea, dementia, death
- toxicity from supplements: elevated blood pressure, cardiac arrhythmia, nausea, vomiting, elevated blood sugar levels, impaired liver function
biotin
functions as a coenzyme in energy metabolism
avidin in raw eggs destroys biotin
deficiency: dermatitis
vitamin B6
- called pyridoxine and comprises a group of compounds including pyridoxal, pyridoxine, and pyridoxamine
- can be converted to pyridoxal phosphate, which is required for many enzyme reactions in the body
- anemia: deficiency due to impaired hemoglobin synth and neurotransmitter issues
toxicity from supplements: irreversible nerve damage
folate (folic acid)
- folate enzymes needed for DNA synthesis and the metabolism of some amino acids
- low intake in early pregnancy is associated with an increased risk of NTDs
- low intake associated with increased risk of heart disease related to the metabolism of homocysteine
vitamin B12
- necessary for proper absorption of iron in the body
- most readily absorbed from animal products, vegan diets need to be supplemented with readily absorbable forms of B12
- atrophic gastritis may lead to deficiencies
- pernicious anemia: deficiency, form of anemia that does not respond to iron supplementation
- excessive intake of folic acid can mask B12 deficiencies
vitamin C
- known as ascorbic acid or ascorbate
- can be destroyed in food by oxygen, light, heat, contact with copper or iron cookware
- antioxidant in the body
- helps maintain the immune system
- important in the production of collagen
- aids in iron absorption
- deficiency: scurvy
malabsorption of fat soluble vitamins
- fat malabsorption leads to deficiencies of fat soluble vitamins
- alcohol abuse and intestinal diseases affect absorption of some B vitamins
vitamin A
- found preformed, from animal products or supplements, or in precursor form, from plant foods
- key role in night vision, cell differentiation, growth regulation
- retinoids: reformed vitamin A compounds; derivative of retinoic acid is used for skin
- carotenoids: precursors to vitamin A found in plants
hypercarotenemia: turn orange
vitamin D
- 80% of vitamin D consumed is incorporated into micelles
- no RDA due to variation in sunlight exposure
- AI: 5 micrograms for under 51, 10 - 15 for over
- light skinned can produce from casual sun
- infants are born w it but recommended supplementation
- increases calcium absorption
vitamin D deficiency and toxicity
- rickets: deficiency in children
- ostromalacia: deficiency in adults
- deficiency means dietary Ca cannot be absorbed efficiently -> improper bond mineralization and abnormalities in bone structure
- over supplementation: high blood and urine Ca concentration, depositing Ca in blood vessels and kidneys, CV damage, death
vitamin K
- named for koagulation; Danish word for coagulation
- phylloquinone: vitamin K in plants
- menaquinone: vitamin K in animals and formed by bacteria
vitamin K deficiency
- rare in the US
- abnormal blood coagulation
- excess vitamin A and E interferes with vitamin K
- newborns are injected with vitamin K, breastmilk is a poor source
vitamin K absorption, storage, and excretion
- absorption requires bile and pancreatic enzymes
- 80% absorbed in small intestine
- 10% of menaquinones synthesized by intestinal bacteria is absorbed in colon
- stored in liver and incorporated into lipoproteins
- excretion is primarily by bile
vitamin K and antibiotics
- destroy intestinal bacteria
- inhibit vitamin K synthesis and absorption
- potential for excessive bleeding
major mineral vs minor
major: needed in over 100 mg/day or are present in over 0.01% of body weight
compounds that interfere with absorption
phytates can limit Ca, Zn, Fe, Mg
Oxalates can limit Ca, Fe
Tannins can limit Fe
minerals as cofactors
- bind to incomplete enzymes to form complete enzyme
- can be reused or separated from enzyme
calcium functions
- provide structure to bones and teeth and has important regulatory roles
- in fluid, plays a role in nerve transmission, muscle contractions, blood pressure regulation, release of hormones
- most abundant mineral in body
osteoporosis
low bone mineral density/mass
calcium absorption
- high concentration allows for absorption by passive diffusion
- low/moderation concentration requires active transport
- vitamin D turns on synthesis of Ca transport proteins, which shuttle Ca from lumen across the mucosal cell
- Ca pump requires energy to move Ca from mucosal cell into blood stream
- bioavailability decreased in the presence of tannins, fiber, phytates, oxalates
calcium regulation
high blood Ca: triggers calcitonin release from thyroid gland, which inhibits Ca release from bones
low blood Ca: triggers PTH release from parathyroid gland, which promotes Ca reabsorption by kidney, stimulates activation of vitamin D by kidney, and stimulates Ca release from bone. active vitamin D increases intestinal Ca absorption
phosphate
-1% of adult body, 85% in bones and teeth
- important component of molecules with structural or regulatory toles
- ATP
- more readily absorbed than Ca
- deficiency can lead to bone loss, weakness, loss of appetite
- toxicity is rare, but can lead to bone resorption
magnesium
-50-60% found in bond, rest is in cells
- cofactor for over 300 enzymes, necessary for generation of energy from carbons, lipids, and proteins
- deficiency: rare, occurs with alcoholism, malnutrition, kidney and GI disease, and diuretics. may cause nausea, muscle weakness and cramping, mental derangement, changes in blood pressure and heart beat