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ADN 120 > EXAM 3 > Flashcards

EXAM 3 Flashcards

1
Q

buspirone use

A

chronic anxiety
safe for regular scheduled use

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2
Q

buspirone MOA

A

binds to serotonin and dopamine receptors in brain

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3
Q

buspirone side effects

A

tachycardia
palpitations
paradoxical anxiety
HA
blurry vision
dizziness
nausea
poor coordination

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4
Q

buspirone considerations

A

non-habit forming
taper
assess hx substance abuse
needs to be taken daily
optimal results take 3-4 wks
drug interaction w/SSRI- serotonin syndrome
lg amounts grapefruit increased effect
do not give with MAOIs

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5
Q

Benzodiazepines MOA

A

decreases CNS activity
enhances GABA

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6
Q

Benzodiazepines Side Effects

A

risk for dependence
sedation
hypotension
impact on psychomotor abilities
dry mouth
dizziness
confusion
headache

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7
Q

Benzodiazepines considerations

A

assess LOC
med hx
risk for falls
avoid abrupt withdrawal
additive effect with other CNS depressants

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8
Q

Benzodiazepines meds

A

alprazolam, diazepam, lorazepam

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9
Q

alprazolam

A

GAd- short term use, oral contraceptives increase effectivness

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10
Q

diazepam

A

anxiety, ETOH withdrawl, status epilepticus, adjuvant for muscle spasm
oral contraceptives can increase effectivness

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11
Q

Lorazepam

A

IVP, continuous IV for severely agitated pts. ETOH withdrawal
status epilepticus IV and IM
oral contraceptives decrease theraputic effectivness

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12
Q

SSRI meds

A

fluoxetine, citalopram, sertraline, escitalopram

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13
Q

SSRI use

A

depression, bipolar, PTSD

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14
Q

SSRI MOA

A

blocks reabsorption of serotonin by nerve cells

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15
Q

SNRIs meds

A

duloxetine, venlafaxine

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16
Q

SNRI use

A

depression, GAD, adjuvant pain

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17
Q

SNRI MOA

A

blocks reabsorption of serotonin and norepinephrine in CNS

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18
Q

Miscellaneous meds

A

bupropion- NDRI, mirtazapine- tetracycline antidep.

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19
Q

bupropion use

A

depression/ SAD

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20
Q

bupropion action

A

decreased neuronal reuptake of dopamine in CNS, diminished neuronal uptake of serotonin and norepinephrine

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21
Q

mirtazapine- tetracycline antidep. use

A

depression, eating disorders, substance abuse

22
Q

mirtazapine- tetracycline antidep. action

A

increase effectivness/ norepinephrine and serotonin, and dopamine

23
Q

mirtazapine-tetracycline antidep. SE

A

weight gain, increased suicidal thoughts

24
Q

Second- Generation Antidepressants meds

A

SSRIs, SNRIs, miscellaneous (bupropion, mirtazapine- tetracycline)

25
Q

Second- generation antidep. SE

A

insomnia
weight gain
anxiety
dizziness
drowsiness
sexual dysfunction
discontinuation syndrome

26
Q

second generation antidep. interactions

A

with other highly protein bound drugs will compete for binding sites
increased bleeding risk with anticoagulans/ NSAIDs
other serotonin enhancing drugs/ herbs will increase risk of serotonin syndrom
ETOH increased risk MAOI increased risk, over counter cold meds icnrease risk

27
Q

First-Generation anitdepressant

A

tricyclic antidepressants (TCAS)

28
Q

TCAs meds

A

amitriptyline

29
Q

TCA use

A

depression, childhood enuresis, adjuvant analgesics for chronic pain conditions, neuropathic pain

30
Q

TCAs MOA

A

potentiates effect of serotonin and norepinephrine in CNS

31
Q

TCA SE

A

sedation
suicidal ideation
anticholinergic (dry mouth, urinary rention, constipation, blurred vision)
dyrhythmias (lethal overdose)
impotence
orthostatic hypotension
ataxia
weight gain
older patients: monitor closely for over- sedation and profound CNS depression

32
Q

TCA interactions

A

overdose- highly lethal
so specific antidote but can decrease drug absorption with activated charcoal

33
Q

TCA considerations

A

monotor ECG
suicidal ideation
weight and BMI before treatment
assess fasting glucose
urine- blue-green
get up slowly
taper, 2 wk washout for surgery
given if second gen fail

34
Q

MAOIs meds

A

phenelzine, tranylcypromine

35
Q

MAOIs use

A

atypical depression

36
Q

MAOI action

A

accumulate dopamine, epinephrine, norepinephrine, and serotonin in body

37
Q

MAOI SE

A

dizziness, dykinesias, nausea, syncope, hypertension

38
Q

MAOI interaction

A

yramine:
-Foods or drinks with tyramine leads to hypertensive crises, which may lead to cerebral hemorrhage, stroke, coma, or death.

-Avoid foods that contain tyramine: Think Charcuterie board such as aged, mature cheeses (cheddar, bleu, Swiss)
Smoked, pickled, or aged meats, fish, poultry (herring, sausage, corned beef, salami, pepperoni, paté)
Yeast extracts
Red wines (Chianti, burgundy, sherry, vermouth)
Italian broad beans (fava beans)

39
Q

MAOI considerations

A

require 3-6 wks effective
no pregnancy
2 wk washout, taper
avoid foods that contain tyramine
serotonin syndrome if taking with SSRI

40
Q

selagiline patch

A

MOAI

41
Q

Selegiline patch use

A

depression

42
Q

selegiline patch MOA

A

icnreases dopamine serotonin and noreprinephrine levels in brain

43
Q

selegiline patch SE

A

nausea, serotonin syndrome

44
Q

selegiline patch interactions

A

no concerns with food inceractiosn at lower dose

45
Q

Selegline patch considerations

A

peds, alochol, avoid external heating measures and sunlight

46
Q

St johns wort (herbal product) use

A

mild/moderate depression
anxiety
sleep disorders
nervousness

47
Q

st. johns wort action

A

antidepressant action may be due to ability to inhibit reuptake of serotonin and other neurotransmitters

48
Q

st. johns wort SE

A

generally well tolerated
fatigue
dizziness
confusion
dry mouth
photosensitivity

49
Q

st. johns wort interactions

A

MAOI, SSRI, TCA, benzodiazepines, tyramine-containing foods, opioids, oral contraceptives

50
Q

st. johns wort considerations

A

pregnancy
breast feeding
peds
may cuase insomnia, anxiety, GI issues, headache, sexual dysfunction
no bipolar
no alzeimers/dementia
avoid ETOH

ADN 120 (3 decks)

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