Exam 3 Flashcards
Beers Criteria
listing of drugs that carry high risks for older adults and criteria for potentially inappropriate medication use in older adults
Biological Half life
the time necessary for half of a drug to be excreted from the body
Pharmacokinetics
refers to the absorption, distribution, metabolism, and excretion of drugs
Pharmacodynamics
refers to the biologic and therapeutic effects of drugs at the site of action or on the target organ
Polypharmacy
use of multiple medications
Age-related changes create
Pharmacokinetics
Pharmocodynamics
Most common mediation?
Cardiovascular agents
Decreased intracellular fluid, increased gastric pH, decreased gastric blood flow and motility, reduced cardiac output and circulation, and slower metabolism can slow drug absorption.
True
Distribution changes in older adults
- changes in circulation
- changes in membrane permeability
- body temperature
- tissue structure
If your liver is not functioning.. you will not
LIVE
Liver influences what?
Drug detoxification and excretion
As you get older what is the central nervous system increasingly sensitive to
- alcohol
- narcotics
- bromides
What is an early identifier to adverse reactions to medications in older adults ?
Change in mental status
Varying degrees of mental dysfunction are often the early signs of adverse reactions to commonly prescribed medications for older adults.
True
Most common route to administering drugs ?
Oral
Fastest route of drug administration?
IV
Aspirin can cause?
Intestinal bleeding
Acetaminophen
lacks anti inflammatory properties can cause liver failure ( hepatic necrosis)
Short Acting Opioids are for ?
Mild/ Moderate pain can cause constipation
Long acting opioids
Severe pain can cause constipation and gastric immobility
What is acetaminophen commonly used to treat
osteoarthritis
What is acetaminophen used for ?
Mild to Moderate Pain
What should the daily does of acetaminophen not exceed ?
4,000 mg
What should not be used for people who have liver disease ?
Acetaminophen
What is one thing you should avoid doing within two hours go giving an antacid?
Avoid administering any other medications within two hour to prevent the antacid from interfering with drug absorption
What can excessive antibiotic use lead to ?
antibiotic resistant bacteria
Which of the following classifications of antibiotics requires close monitoring for hearing loss and renal failure ?
Amino-glycosides
Why do ahminoglycosides require close monitoring
because they can increase the risk of hearing loss and renal failure
What are the two main Anticoagulants
Heparin and Coumarin
When must you administer anticoagulants?
You must administer anticoagulants at the same time to maintain a constant blood level
What do anticoagulants put you at a higher risk for
Bleeding
What foods can reduce the effectiveness of anticoagulants
those foods rich in vitamin K .
Mango and Papaya can increase what ?
INR
Why should patients avoid aspirin with anticoagulants
it can interfere with platelet aggregation and it can cause bleeding
What are some possible side effects of anticoagulants
bruising pallor weakness jaundice confusion agitation
What can anticoagulants depress
psychomotor activity
Should anticonvulsants be stopped abruptly
NO
Can grapefruit juice be ingested while taking
No it increases the risk of toxicity
what patients should be monitored closely while taking anticonvulsants
those with glaucoma, CAD, prostate disease
What can anticonvulsants cause
photosensitivity
What is the most common antihypertensive drug
diuretics
beta- blockers
calcium channel blockers
What is important to monitor when taking antihypertensives drugs
monitoring potassium
What do NSAID’s have ?
A narrow therapeutic window
NSAID’s have to be taken with what
food or a glass of mild, to reduce GI irritation
What should be monitored when taking cholesterol lowering drugs
ensure that patients receive liver function tests
Cholinesterase Inhibitors
Aricept, Exelon, and Razadyne