Exam 2 - wounds Flashcards
epidermis
- outer layer of skin
- avascular
- regenerates every 4-6 weeks
Dermis
-has 2 layers (papillary = thin, vascular next to epidermis)
(reticular = deep layer containing skin appendages)
-*repairs via scar formation
subcutaneous tissue
- adipose and connective tissue
- contains major blood vessels, nerves, and lymphatic vessels.
LE ulcers increase amputation risk by?
6x
what are 6 functions of the skin?
- protection
- maintain fluid status
- thermoregulation
- produce vit D
- sensation
- psychosocial
Inflammatory phase of healing
- first phase
- lasts 4-6 days
- characterized by: neutrophils(most), macrophages, and lymphocytes
what are the cardinal signs of inflammation? (5)
- calor (warm)
- rubor (redness)
- tumor (swelling)
- dolor (pain)
- loss of function
Proliferative phase of healing
- ~4 to 3-6weeks
- characterized by: granulation tissue formation, wound contraction, and epithelialization
Angiogenesis
- formation of new blood vessels
- happens in proliferative phase with granulation tissue formation
Maturation phase of healing
- can last 1-2 years
- balance between collagen synthesis and lysis.
- remodeling and reorganization (tension theory)
Hypertrophic scar
raised but within area of normal tissue
keloid scar
extends beyond border of wound
most neutrophils during what phase?
inflammatory
most macrophages during what phase?
inflammatory
most fibroblasts during what phase?
proliferation
most lymphocytes during what phase?
proliferation
Primary intention
wound edges approximated (surgical), minimal proliferative phase
Secondary intention
- wound edges left open and healing occurs by formation of granulation tissue contraction, and epithelization
tertiary intention
wound left open temporarily before surgical closure
Dehiscence
a wound closed by primary intention that later opens up again
intrinsic factors affecting wound healing
- age
- chronic disease (DM, CAD,PVD, cancer)
- perfusion and oxygenation
- immunosuppression
- sensation (SCI, DM neuropathy)
- stress
extrinsic factors affecting wound healing
- meds
- nutrition
- smoking and EtOH
- infection
- mechanical stress
- **tissue moisture
Lab values and delayed healing: Prealbumin, albumin, hemoglobin, hematocrit, WBC, BUN:Creatinine
- Prealbumin less than 16 mg/dl
- Albumin less than 3.5 mg/dl
- Hemoglobin less than 12 g/dl
- Hematocrit less than 33%
- WBC less than 1800/mm3
- BUN/Creatinine over 10:1
contamination def
-presence of bacteria in wound surface
colonization def
replication bacteria present in wound but without tissue response
Critical colonization def
bacteria delay or stop healing of the wound without presence of classical symptoms and signs of infection
infection def
bacterial burden overwhelms the immune response of the patient, wound is unable to heal, have symptoms of infection
what are the signs of infection?
- Inflammatory signs (rubber, dolor, tumor, color)
- purulent drainage/pus
- foul odor
- tissue induration
- fever, tachycardia
- WBC > 10,000/mm^3
osteomyelitis
-inflammation of bone caused by infecting organism, lead to progressive destruction of bone and necrosis